Evidence map›Paper›PMID 30775849›Full record

ReviewAmerican journal of medical genetics. Part C, Seminars in medical genetics2019

Cardiometabolic health in Turner syndrome.

Shanlee M Davis, Mitchell E Geffner

Open access · greenAbstract readReview
In one paragraph

Review in American journal of medical genetics. Part C, Seminars in medical genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Guideline
  2. Article
  3. Article
  4. Impact of Clinical Factors on Bone Microarchitecture in Patients with Turner Syndrome.Endocrine, metabolic & immune disorders drug targets · 2026
    Article
  5. Article
  6. Lifelong medical challenges and immunogenetics of Turner syndrome.Clinical and experimental pediatrics · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. A Review of Recent Developments in Turner Syndrome Research.Journal of cardiovascular development and disease · 2021
    Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Shanlee M DavisDepartment of Pediatrics, University of Colorado School of Medicine, 13123 East 16th B265, Aurora, Colorado.ORCID 0000-0002-0304-9550
Mitchell E GeffnerChildren's Hospital Los Angeles, The Saban Research Institute, 4650 Sunset Blvd., MS #61, Los Angeles, California.
Children's Hospital of Los Angeles · USUniversity of Colorado Denver · US

Funding

Center for Clinical and Translational Sciences (CCTS)UL1TR000371 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MCPHERSON, DAVID D · 2012 to 2016
$13.4M
TESTO: Testosterone Effects on Short-Term Outcomes in Infants with XXYK23HD092588 · NICHD · UNIVERSITY OF COLORADO DENVER · PI DAVIS, SHANLEE · 2017 to 2021
$826k
NCATS NIH HHS UL1 TR000371NICHD NIH HHS K23 HD092588NICHD NIH HHS L40 HD089378Patient-Centered Outcomes Research Institute (PCORI) Eugene Washington PCORI Engagement Award 10460
6 · The paper itself

Abstract

Individuals with Turner syndrome (TS) have a higher morbidity and mortality compared to the general population. Diabetes and cardiovascular disease are the major contributors to this burden. Precursors to diabetes and cardiovascular disease make up what is known as metabolic syndrome, including abdominal obesity, hypertension, dyslipidemia, and elevated fasting glucose. These features of poor cardiometabolic health are also prevalent among women with TS. Youth with TS also exhibit many of these features, indicating that the pathogenesis of these cardiometabolic conditions may begin early in life. The etiology of the increased risk of cardiometabolic conditions in TS is likely multifactorial, involving genetics, epigenetics, hypogonadism, medical comorbidities, medications, and lifestyle. Counseling for the increased risk of cardiometabolic diseases as well as efforts to prevent or lower this risk should be routinely provided in the care of all patients with TS. Clinical practice guidelines are now available to guide screening and treatment of cardiometabolic conditions in girls and women with TS.

Indexed as

Cardiovascular DiseasesDiabetes Mellitus, Type 2FemaleHumansMetabolic SyndromeRiskTurner Syndromediabetesepigeneticsmetabolic syndromesex chromosome aneuploidyTurner syndrome

Identifiers

PMID30775849
PMCPMC7382389
OpenAlexW2917697090

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.