ArticleScientific reports2019
Environmental Toxicant Induced Epigenetic Transgenerational Inheritance of Prostate Pathology and Stromal-Epithelial Cell Epigenome and Transcriptome Alterations: Ancestral Origins of Prostate Disease.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Effects of perinatal exposure to endocrine-disrupting chemicals on the reproductive system of F3 generation male rodents: a meta-analysis.Environmental science and pollution research international · 2022Pooled it
- Transgenerational epigenetic effects from male exposure to endocrine-disrupting compounds: a systematic review on research in mammals.Clinical epigenetics · 2020Pooled it
- Phthalates and epigenetics: An emerging public health concern.Current research in toxicology · 2025Review
- A systematic scientometric review of paternal inheritance of acquired metabolic traits.BMC biology · 2023Review
- Recruitment of CTCF to anProceedings of the National Academy of Sciences of the United States of America · 2022Article
- FOXO3a-ROS pathway is involved in androgen-induced proliferation of prostate cancer cell.BMC urology · 2022Article
- Endocrine Disruptors and Prostate Cancer.International journal of molecular sciences · 2022Review
- Role of epigenetic transgenerational inheritance in generational toxicology.Environmental epigenetics · 2022Review
- Combined Effects of Different Endocrine-Disrupting Chemicals (EDCs) on Prostate Gland.International journal of environmental research and public health · 2021Review
- Breast and prostate glands affected by environmental substances (Review).Oncology reports · 2021Review
- Sperm DNA methylation epimutation biomarker for paternal offspring autism susceptibility.Clinical epigenetics · 2021Article
- Environmentally Induced Epigenetic Transgenerational Inheritance and the Weismann Barrier: The Dawn of Neo-Lamarckian Theory.Journal of developmental biology · 2020Review
- Developmental origins of transgenerational sperm histone retention following ancestral exposures.Developmental biology · 2020Article
- Differential susceptibility to endocrine disruptor-induced epimutagenesis.Environmental epigenetics · 2020Review
- The Promises and Challenges of Toxico-Epigenomics: Environmental Chemicals and Their Impacts on the Epigenome.Environmental health perspectives · 2020Article
- Article
- The Ancestral Environment Shapes Antiviral CD8iScience · 2019Article
- Environmentally-Induced Transgenerational Epigenetic Inheritance: Implication of PIWI Interacting RNAs.Cells · 2019Review
- Epigenetic transgenerational inheritance of testis pathology and Sertoli cell epimutations: generational origins of male infertility.Environmental epigenetics · 2019Article
- Di (2-ethylhexyl) Phthalate Exposure Impairs the microRNAs Expression Profile During Primordial Follicle Assembly.Frontiers in endocrinology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Prostate diseases include prostate cancer, which is the second most common male neoplasia, and benign prostatic hyperplasia (BPH), which affects approximately 50% of men. The incidence of prostate disease is increasing, and some of this increase may be attributable to ancestral exposure to environmental toxicants and epigenetic transgenerational inheritance mechanisms. The goal of the current study was to determine the effects that exposure of gestating female rats to vinclozolin has on the epigenetic transgenerational inheritance of prostate disease, and to characterize by what molecular epigenetic mechanisms this has occurred. Gestating female rats (F0 generation) were exposed to vinclozolin during E8-E14 of gestation. F1 generation offspring were bred to produce the F2 generation, which were bred to produce the transgenerational F3 generation. The transgenerational F3 generation vinclozolin lineage males at 12 months of age had an increased incidence of prostate histopathology and abnormalities compared to the control lineage. Ventral prostate epithelial and stromal cells were isolated from F3 generation 20-day old rats, prior to the onset of pathology, and used to obtain DNA and RNA for analysis. Results indicate that there were transgenerational changes in gene expression, noncoding RNA expression, and DNA methylation in both cell types. Our results suggest that ancestral exposure to vinclozolin at a critical period of gestation induces the epigenetic transgenerational inheritance of prostate stromal and epithelial cell changes in both the epigenome and transcriptome that ultimately lead to prostate disease susceptibility and may serve as a source of the increased incidence of prostate pathology observed in recent years.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.