Evidence map›Paper›PMID 30780167›Full record

ArticleThrombosis and haemostasis2019

Plasma Concentrations of High Molecular Weight Kininogen and Prekallikrein and Venous Thromboembolism Incidence in the General Population.

Aaron R Folsom, Weihong Tang, Saonli Basu, Jeffrey R Misialek, David Couper, Susan R Heckbert, Mary Cushman

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Thrombosis and haemostasis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Aaron R FolsomDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, United States.
Weihong TangDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, United States.
Saonli BasuDivision of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, Minnesota, United States.
Jeffrey R MisialekDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, United States.ORCID 0000-0003-4583-786X
David CouperDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.
Susan R HeckbertDepartment of Epidemiology, University of Washington, Seattle, Washington, United States.
Mary CushmanDepartment of Medicine, University of Vermont, Burlington, Vermont, United States.
University of Minnesota · USUniversity of North Carolina at Chapel Hill · USUniversity of Vermont · USUniversity of Washington · US

Funding

EPIDEMIOLOGY OF VENOUS THROMBOSIS AND PULMONARY EMBOLISMR01HL059367 · UNIVERSITY OF MINNESOTA TWIN CITIES · 1998 to 2005
$1.9M
NHLBI NIH HHS HHSN268201700001CNHLBI NIH HHS HHSN268201700001INHLBI NIH HHS HHSN268201700002CNHLBI NIH HHS HHSN268201700002INHLBI NIH HHS HHSN268201700003CNHLBI NIH HHS HHSN268201700003INHLBI NIH HHS HHSN268201700004CNHLBI NIH HHS HHSN268201700004INHLBI NIH HHS HHSN268201700005CNHLBI NIH HHS HHSN268201700005INHLBI NIH HHS R01 HL059367
6 · The paper itself

Abstract

The kallikrein/kinin system, an intravascular biochemical pathway that includes several proteins involved in the contact activation system of coagulation, renin-angiotensin activation and inflammation, may or may not play a role in venous thromboembolism (VTE) occurrence. Within a large prospective population-based study in the United States, we conducted a nested case-cohort study to test the hypothesis that higher plasma levels of high molecular weight kininogen (HK) or prekallikrein are associated with greater VTE incidence. We related baseline enzyme-linked immunosorbent assay measures of HK and prekallikrein in 1993 to 1995 to incidence VTE of the lower extremity (

Indexed as

Population GroupsBlood CoagulationCase-Control StudiesCohort StudiesFemaleFollow-Up StudiesHumansIncidenceKallikrein-Kinin SystemKininogen, High-Molecular-WeightMaleMiddle AgedPlasmaPrekallikreinProspective StudiesRiskKininogen, High-Molecular-WeightPrekallikrein

Identifiers

PMID30780167
PMCPMC6499653
OpenAlexW2916737296

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.