SynthesisNature communications2019
Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations.
Erratum issuedOpen access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 62 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 3 pooled it
7.0field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
62 citing papers in PubMed, 3 syntheses or guidelines pooled it, 101 citations in OpenAlex.
- Novel ancestry-specific primary open-angle glaucoma loci and shared biology with vascular mechanisms and cell proliferation.Cell reports. Medicine · 2024Pooled it
- Multi-ancestry meta-analysis and fine-mapping in Alzheimer's disease.Molecular psychiatry · 2023Pooled it
- Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma.Nature communications · 2020Pooled it
- Mechanisms and therapeutic strategies of asthma: from bench to bedside.Signal transduction and targeted therapy · 2026Review
- Associations between genetic ancestry and allergic outcomes at 10 years among Black children.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2026Article
- Cumulative genetic risk for asthma contributes to disease severity in children with asthma.The journal of allergy and clinical immunology. Global · 2026Article
- African Pan Genome Contigs Expose Biologically Relevant Sequence Still Hidden from Human Reference Frameworks.bioRxiv : the preprint server for biology · 2026Article
- Why Are Some Children More Sick Than Others? Lessons From Genome-wide Association Studies of Respiratory Viral Infections.The Pediatric infectious disease journal · 2026Article
- Gene-environment interaction at 17q12-q21 locus and its role in asthma pathogenesis.The European respiratory journal · 2025Article
- Cumulative Genetic Risk for Asthma Contributes to Disease Severity in Children with Asthma living in Urban Environments.medRxiv : the preprint server for health sciences · 2025Article
- Article
- Chromosome 21 variants tied to severe asthma exacerbations: A genome-wide association study in a Brazilian population.The journal of allergy and clinical immunology. Global · 2025Article
- Shared genetic investigation of asthma and blood eosinophils in relation to chronic rhinosinusitis.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2025Article
- Bioaerosols and Airway Diseases: Mechanisms of Epithelial Dysfunction, Immune Activation, and Strategies for Exposure Mitigation.Archives of internal medicine research · 2025Article
- DNA-binding factor footprints and enhancer RNAs identify functional non-coding genetic variants.Genome biology · 2024Article
- Predictive genetic panel for adult asthma using machine learning methods.The journal of allergy and clinical immunology. Global · 2024Article
- Multi-omics in nasal epithelium reveals three axes of dysregulation for asthma risk in the African Diaspora populations.Nature communications · 2024Article
- Chronic Overlapping Pain Conditions and Nociplastic Pain.medRxiv : the preprint server for health sciences · 2024Article
- Adjusting for principal components can induce spurious associations in genome-wide association studies in admixed populations.bioRxiv : the preprint server for biology · 2024Article
- Impact of climate change on paediatric respiratory health: pollutants and aeroallergens.European respiratory review : an official journal of the European Respiratory Society · 2024Review
2 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
66 authors at 20 institutions in 11 countries.
Michelle DayaDepartment of Medicine, University of Colorado Denver, Aurora, CO, 80045, USA.
Nicholas RafaelsDepartment of Medicine, University of Colorado Denver, Aurora, CO, 80045, USA.
Tonya M BrunettiDepartment of Medicine, University of Colorado Denver, Aurora, CO, 80045, USA.
Sameer ChavanDepartment of Medicine, University of Colorado Denver, Aurora, CO, 80045, USA.
Albert M LevinDepartment of Public Health Sciences, Henry Ford Health System, Detroit, MI, 48202, USA.
Aniket ShettyDepartment of Medicine, University of Colorado Denver, Aurora, CO, 80045, USA.
Christopher R GignouxDepartment of Medicine, University of Colorado Denver, Aurora, CO, 80045, USA.
Meher Preethi BoorgulaDepartment of Medicine, University of Colorado Denver, Aurora, CO, 80045, USA.
Genevieve WojcikDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, 94305, USA.ORCID http://orcid.org/0000-0001-7206-8088
Monica CampbellDepartment of Medicine, University of Colorado Denver, Aurora, CO, 80045, USA.
Candelaria VergaraDepartment of Medicine, Johns Hopkins University, Baltimore, MD, 21224, USA.ORCID http://orcid.org/0000-0003-3297-8057
Dara G TorgersonDepartment of Medicine, University of California San Francisco, San Francisco, CA, 94143, USA.
Victor E OrtegaCenter for Human Genomics and Personalized Medicine, Wake Forest School of Medicine, Winston-Salem, 27157, USA.
Ayo DoumateyCenter for Research on Genomics & Global Health, National Institutes of Health, Bethesda, MD, 20892, USA.
Henry Richard JohnstonDepartment of Human Genetics, Emory University, Atlanta, GA, 30322, USA.
Nathalie AcevedoInstitute for Immunological Research, Universidad de Cartagena, Cartagena, 130000, Colombia.
Maria Ilma AraujoImmunology Service, Universidade Federal da Bahia, Salvador, 401110170, Brazil.
Pedro C AvilaDepartment of Medicine, Northwestern University, Chicago, IL, 60611, USA.ORCID http://orcid.org/0000-0002-1358-7256
Gillian BelbinDepartment of Genetics and Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Eugene BleeckerDepartment of Medicine, University of Arizona College of Medicine, Tucson, AZ, 85724, USA.
Carlos BustamanteDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Luis CaraballoInstitute for Immunological Research, Universidad de Cartagena, Cartagena, 130000, Colombia.
Alvaro CruzUniversidade Federal da Bahia, Salvador, 401110170, Brazil.
Georgia M DunstonDepartment of Microbiology, Howard University College of Medicine, Washington, DC, 20059, USA.
Celeste EngDepartment of Medicine, University of California San Francisco, San Francisco, CA, 94143, USA.
Mezbah U FaruqueNational Human Genome Center, Howard University College of Medicine, Washington, DC, 20059, USA.
Trevor S FergusonCaribbean Institute for Health Research, The University of the West Indies, Kingston, 00007, Jamaica.ORCID http://orcid.org/0000-0002-2393-1452
Camila FigueiredoDepartamento de Biorregulacao, Universidade Federal da Bahia, Salvador, 401110170, Brazil.
Jean G FordDepartment of Medicine, Einstein Medical Center, Philadelphia, PA, 19141, USA.
Weiniu GanNational Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Pierre-Antoine GourraudUniversité de Nantes, INSERM, Centre de Recherche en Transplantation et Immunologie, UMR, 1064, ATIP-Avenir, Equipe 5, Nantes, France.
Nadia N HanselDepartment of Medicine, Johns Hopkins University, Baltimore, MD, 21224, USA.
Ryan D HernandezDepartment of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, 94143, USA.
Edwin Francisco Herrera-PazFacultad de Medicina, Universidad Católica de Honduras, San Pedro Sula, 21102, Honduras.ORCID http://orcid.org/0000-0001-9437-6620
Silvia JiménezInstitute for Immunological Research, Universidad de Cartagena, Cartagena, 130000, Colombia.
Eimear E KennyDepartment of Genetics and Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Jennifer Knight-MaddenCaribbean Institute for Health Research, The University of the West Indies, Kingston, 00007, Jamaica.
Rajesh KumarDepartment of Pediatrics, Northwestern University, Chicago, IL, 60611, USA.
Leslie A LangeDepartment of Medicine, University of Colorado Denver, Aurora, CO, 80045, USA.
Ethan M LangeDepartment of Medicine, University of Colorado Denver, Aurora, CO, 80045, USA.
Antoine LizeeUniversité de Nantes, INSERM, Centre de Recherche en Transplantation et Immunologie, UMR, 1064, ATIP-Avenir, Equipe 5, Nantes, France.
Pissamai MaulGenetics and Epidemiology of Asthma in Barbados, The University of the West Indies, Chronic Disease Research Centre, Jemmots Lane, St. Michael, BB11115, Barbados.
Trevor MaulGenetics and Epidemiology of Asthma in Barbados, The University of the West Indies, Chronic Disease Research Centre, Jemmots Lane, St. Michael, BB11115, Barbados.
Alvaro MayorgaCentro de Neumologia y Alergias, San Pedro Sula, 21102, Honduras.
Deborah MeyersDepartment of Medicine, University of Arizona College of Medicine, Tucson, AZ, 85724, USA.
Dan L NicolaeDepartment of Medicine, University of Chicago, Chicago, IL, 60637, USA.
Timothy D O'ConnorInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Ricardo Riccio OliveiraLaboratório de Patologia Experimental, Centro de Pesquisas Gonçalo Moniz, Salvador, 40296-710, Brazil.
Christopher O OlopadeDepartment of Medicine and Center for Global Health, University of Chicago, Chicago, IL, 60637, USA.
Olufunmilayo OlopadeDepartment of Medicine, University of Chicago, Chicago, IL, 60637, USA.
Zhaohui S QinDepartment of Biostatistics and Bioinformatics, Emory University, Atlanta, GA, 30322, USA.ORCID http://orcid.org/0000-0002-1583-146X
Charles RotimiCenter for Research on Genomics & Global Health, National Institutes of Health, Bethesda, MD, 20892, USA.ORCID http://orcid.org/0000-0001-5759-053X
Nicolas VinceUniversité de Nantes, INSERM, Centre de Recherche en Transplantation et Immunologie, UMR, 1064, ATIP-Avenir, Equipe 5, Nantes, France.ORCID http://orcid.org/0000-0002-3767-6210
Harold WatsonFaculty of Medical Sciences, The University of the West Indies, Queen Elizabeth Hospital, Bridgetown, St. Michael, BB11000, Barbados.
Rainford J WilksCaribbean Institute for Health Research, The University of the West Indies, Kingston, 00007, Jamaica.
James G WilsonDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, 39216, USA.
Steven SalzbergDepartments of Biomedical Engineering and Biostatistics, Johns Hopkins University, Baltimore, MD, 21205, USA.ORCID http://orcid.org/0000-0002-8859-7432
Carole OberDepartment of Human Genetics, University of Chicago, Chicago, IL, 60637, USA.
Esteban G BurchardDepartment of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, 94143, USA.
L Keoki WilliamsCenter for Individualized and Genomic Medicine Research, Henry Ford Health System, Detroit, MI, 48202, USA.
Terri H BeatyDepartment of Epidemiology, Bloomberg School of Public Health, JHU, Baltimore, MD, 21205, USA.ORCID http://orcid.org/0000-0002-7644-1705
Margaret A TaubDepartment of Biostatistics, Bloomberg School of Public Health, JHU, Baltimore, MD, 21205, USA.
Ingo RuczinskiDepartment of Biostatistics, Bloomberg School of Public Health, JHU, Baltimore, MD, 21205, USA.
Rasika A MathiasDepartment of Medicine, Johns Hopkins University, Baltimore, MD, 21224, USA.
Kathleen C BarnesDepartment of Medicine, University of Colorado Denver, Aurora, CO, 80045, USA. kathleen.barnes@ucdenver.edu.
CAAPA
Johns Hopkins University · USUniversity of Colorado Denver · USNorthwestern University · USUniversity of California, San Francisco · USUniversity of Cartagena · COUniversidad Católica de Honduras Nuestra Señora Reina de la Paz · HNUniversity of Chicago · USEmory University · USInserm · FRJackson Memorial Hospital · USNational Institutes of Health · USUniversidade Federal da Bahia · BRUniversity of Maryland, Baltimore · USUniversity of the West Indies · BBUniversity of the West Indies · JMCentral American Technological University · HNCentre de Recherche Médicales de Lambaréné · GAHenry Ford Health System · USHonduras Foundation for Agricultural Research · HNHoward University · US
Funding
Tracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI GOMEZ-SANCHEZ, CELSO ENRIQUE · 2016 to 2025
$38.2MRole of obesity in preeclamptic pregnancy.P20GM121334 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI Pier Paolo Claudio, Babbette LaMarca · 2017 to 2026
$26.4MNew Approaches for Empowering Studies of Asthma in Populations of African DescentR01HL104608 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI BARNES, KATHLEEN C, KENNY, EIMEAR ELIZABETH · 2011 to 2022
$23.1MPopulation-based CRS epidemiology: sex differences, natural history, and long-term outcomes based on clinically-defined phenotypes and biologically-based endotypes - GeisingerP01AI145818 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KATO, ATSUSHI · 2019 to 2023
$9.3MSystems Genetics Approach to Gene Discovery in Chronic RhinosinusitisU19AI106683 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SCHLEIMER, ROBERT P · 2014 to 2017
$7.9MPHARMACOGENOMICS OF INHALED CORTICOSTEROID RESPONSIVENESS IN PATIENTS WITH ASTHMAR01AI079139 · NIAID · HENRY FORD HEALTH SYSTEM · PI WILLIAMS, KEOKI · 2009 to 2013
$3.9MFunctional impact of IL33 polymorphisms on asthma & other Th2-mediated diseasesR01HL112088 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI BARNES, KATHLEEN C · 2012 to 2016
$3.6MGlucocorticosteroid Action In Inflammatory DiseaseR37HL068546 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SCHLEIMER, ROBERT P · 2009 to 2018
$3.5MMulti-omic studies of asthma severity in an African ancestry populationR01AI132476 · NIAID · UNIVERSITY OF COLORADO DENVER · PI BARNES, KATHLEEN C, MATHIAS, RASIKA ANN · 2018 to 2022
$3.5MLeveraging electronic medical records to perform large-scale diabetes pharmacogenomics among ancestrally diverse patient populationsR01DK113003 · NIDDK · HENRY FORD HEALTH SYSTEM · PI WILLIAMS, KEOKI · 2017 to 2021
$3.2MPoly-omic Study of Asthma Exacerbations in Diverse PopulationsR01HL141845 · NHLBI · HENRY FORD HEALTH SYSTEM · PI WILLIAMS, KEOKI · 2019 to 2022
$3.0MCombined Transcriptomics and Genomics to Find Asthma Genes in Admixed PopulationsR01HL118267 · NHLBI · HENRY FORD HEALTH SYSTEM · PI WILLIAMS, KEOKI · 2014 to 2017
$2.9MNHLBI NIH HHS R01 HL104608NHLBI NIH HHS R01 HL112088NHLBI NIH HHS R01 HL118267NHLBI NIH HHS R01 HL129239NHLBI NIH HHS R01 HL141845NHLBI NIH HHS R37 HL068546NIAID NIH HHS P01 AI145818NIAID NIH HHS R01 AI079139NIAID NIH HHS R01 AI132476NIAID NIH HHS U19 AI106683NIDDK NIH HHS R01 DK113003NIGMS NIH HHS P20 GM121334NIGMS NIH HHS R01 GM116065NIGMS NIH HHS U54 GM115428NIH HHS S10 OD018522
Abstract
Asthma is a complex disease with striking disparities across racial and ethnic groups. Despite its relatively high burden, representation of individuals of African ancestry in asthma genome-wide association studies (GWAS) has been inadequate, and true associations in these underrepresented minority groups have been inconclusive. We report the results of a genome-wide meta-analysis from the Consortium on Asthma among African Ancestry Populations (CAAPA; 7009 asthma cases, 7645 controls). We find strong evidence for association at four previously reported asthma loci whose discovery was driven largely by non-African populations, including the chromosome 17q12-q21 locus and the chr12q13 region, a novel (and not previously replicated) asthma locus recently identified by the Trans-National Asthma Genetic Consortium (TAGC). An additional seven loci reported by TAGC show marginal evidence for association in CAAPA. We also identify two novel loci (8p23 and 8q24) that may be specific to asthma risk in African ancestry populations.
Indexed as
AsthmaBlack or African AmericanChromosomes, Human, Pair 12Chromosomes, Human, Pair 17Chromosomes, Human, Pair 8Genetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyHispanic or LatinoHumansPolymorphism, Single NucleotideUnited States
Identifiers
What Socratic holds
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LicenceCC BY
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.