Evidence map›Paper›PMID 30795543›Full record

ArticleMolecules (Basel, Switzerland)2019

Long-Term Diabetic Microenvironment Augments the Decay Rate of Capsaicin-Induced Currents in Mouse Dorsal Root Ganglion Neurons.

Xingjuan Chen, Yaqian Duan, Ashley M Riley, Megan A Welch, Fletcher A White, Maria B Grant, Alexander G Obukhov

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Xingjuan ChenDepartment of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA. xingjuanchen@yahoo.com.
Yaqian DuanDepartment of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA. yaqduan@umail.iu.edu.
Ashley M RileyDepartment of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA. ashlrile@indiana.edu.
Megan A WelchDepartment of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA. megwelch@imail.iu.edu.
Fletcher A WhiteDepartment of Anesthesia, Indiana University School of Medicine, Indianapolis, IN 46202, USA. fawhite@iu.edu.ORCID 0000-0002-8408-9262
Maria B GrantDepartment of Ophthalmology and Visual Sciences, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA. mariagrant@uabmc.edu.
Alexander G ObukhovDepartment of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA. aobukhov@iu.edu.ORCID 0000-0002-3862-6004
Indiana University School of MedicineUniversity of Alabama at Birmingham · USRichard L. Roudebush VA Medical Center · US

Funding

University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Stuart J Frank · 2013 to 2026
$19.5M
NITRIC OXIDE IN THE PATHOGENESIS OF DIABETIC RETINOPATHYR01EY012601 · NEI · UNIVERSITY OF FLORIDA · PI Julia V Busik, Maria Bartolomeo Grant · 1998 to 2026
$9.6M
Targeting the IGF-1 System in Retinal AngiogenesisR01EY007739 · NEI · UNIVERSITY OF FLORIDA · PI ABCOUWER, STEVEN F, GRANT, MARIA BARTOLOMEO · 1995 to 2015
$5.4M
TRPC Channels in the Metabolic SyndromeR01HL115140 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI OBUKHOV, ALEXANDER G. · 2012 to 2016
$2.6M
The role of cell-specific TLR-4 signaling in oxaliplatin-induced peripheral neuropathyR01NS102415 · NINDS · INDIANA UNIVERSITY INDIANAPOLIS · PI WHITE, FLETCHER A · 2018 to 2022
$2.2M
Vascular Reparative Mechanism by ACE2/Ang-(1-7)in DiabetesR01HL110170 · NHLBI · UNIVERSITY OF FLORIDA · PI GRANT, MARIA BARTOLOMEO · 2011 to 2015
$2.2M
Somatostatin blockade of CNS autonomic hyperactivity for treatment of diabetic retinopathyR01EY028037 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BOULTON, MICHAEL EDWIN, FRAZIER, CHARLES J · 2017 to 2020
$1.9M
Chemokine signaling in the transition from acute to chronic painI01BX002209 · VA · RLR VA MEDICAL CENTER · PI WHITE, FLETCHER A · 2014 to 2017
–
BLRD VA I01 BX002209National Institute of Heart Lung and Blood Institute, NIH HL115140NEI NIH HHS R01 EY007739NEI NIH HHS R01 EY012601NEI NIH HHS R01 EY028037NHLBI NIH HHS R01 HL110170NHLBI NIH HHS R01 HL115140NIDDK NIH HHS P30 DK079626NINDS NIH HHS R01 NS102415
6 · The paper itself

Abstract

Individuals with end-stage diabetic peripheral neuropathy present with decreased pain sensation. Transient receptor potential vanilloid type 1 (TRPV1) is implicated in pain signaling and resides on sensory dorsal root ganglion (DRG) neurons. We investigated the expression and functional activity of TRPV1 in DRG neurons of the

Indexed as

AnimalsCalciumCapsaicinDiabetic NeuropathiesDisease Models, AnimalFluoresceinsFluorescent DyesGanglia, SpinalGene Expression RegulationGlucoseIon TransportMaleMembrane PotentialsMiceMice, Inbred C57BLMice, Transgenic2',7'-dichlorodihydrofluorescein diacetateCalciumCapsaicinFluoresceinsFluorescent DyesGlucoseReactive Oxygen SpeciesTRPV1 protein, mouseTRPV Cation Channelscalcium influxcapsaicinDRG neuronsIns2+/Akita mouseROSTRPV1

Identifiers

PMID30795543
PMCPMC6412516
OpenAlexW2916875713

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.