ArticleGenetics2019
Modeling Heterogeneity in the Genetic Architecture of Ethnically Diverse Groups Using Random Effect Interaction Models.
Article in Genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Fast analysis of biobank-size data and meta-analysis using the BGLR R-package.G3 (Bethesda, Md.) · 2025Pooled it
- Discovering common and population-specific QTLs for leaf rust resistance in different Barley populations.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Cross-population validation of European GWAS loci for metabolic syndrome in Chinese schizophrenia.BMC psychiatry · 2026Article
- Improving polygenic score prediction for underrepresented groups through transfer learning.Nature communications · 2026Article
- Concordance between male- and female-specific GWAS results helps define underlying genetic architecture of complex traits.Nature communications · 2025Article
- Genetic mapping of serum metabolome to chronic diseases among Han Chinese.Cell genomics · 2025Article
- Mapping the relative accuracy of cross-ancestry prediction.Nature communications · 2024Article
- Cross-ancestry genetic architecture and prediction for cholesterol traits.Human genetics · 2024Article
- Incorporating genetic similarity of auxiliary samples into eGene identification under the transfer learning framework.Journal of translational medicine · 2024Article
- Improving polygenic risk prediction in admixed populations by explicitly modeling ancestral-differential effects via GAUDI.Nature communications · 2024Article
- Bridging the diversity gap: Analytical and study design considerations for improving the accuracy of trans-ancestry genetic prediction.HGG advances · 2023Article
- Evaluating significance of European-associated index SNPs in the East Asian population for 31 complex phenotypes.BMC genomics · 2023Article
- Similarity and diversity of genetic architecture for complex traits between East Asian and European populations.BMC genomics · 2023Article
- Genomic selection for genotype performance and environmental stability in Coffea canephora.G3 (Bethesda, Md.) · 2023Article
- A method for an unbiased estimate of cross-ancestry genetic correlation using individual-level data.Nature communications · 2023Article
- Article
- Genome-wide marker effect heterogeneity is associated with a large effect dormancy locus in winter malting barley.The plant genome · 2022Article
- Detecting associated genes for complex traits shared across East Asian and European populations under the framework of composite null hypothesis testing.Journal of translational medicine · 2022Article
- Importance of Including Non-European Populations in Large Human Genetic Studies to Enhance Precision Medicine.Annual review of biomedical data science · 2022Review
- Population differentiation of polygenic score predictions under stabilizing selection.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
In humans, most genome-wide association studies have been conducted using data from Caucasians and many of the reported findings have not replicated in other populations. This lack of replication may be due to statistical issues (small sample sizes or confounding) or perhaps more fundamentally to differences in the genetic architecture of traits between ethnically diverse subpopulations. What aspects of the genetic architecture of traits vary between subpopulations and how can this be quantified? We consider studying effect heterogeneity using Bayesian random effect interaction models. The proposed methodology can be applied using shrinkage and variable selection methods, and produces useful information about effect heterogeneity in the form of whole-genome summaries (
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.