ArticleBritish journal of pharmacology2019
Evidence for metabotropic function of epithelial nicotinic cholinergic receptors in rat colon.
Article in British journal of pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 5 citations in OpenAlex.
- Activation ofAmerican journal of physiology. Cell physiology · 2021Article
- Nicotine stimulates ion transport via metabotropic β4 subunit containing nicotinic ACh receptors.British journal of pharmacology · 2020Article
- Evidence for metabotropic function of epithelial nicotinic cholinergic receptors in rat colon.British journal of pharmacology · 2019Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeACh exerts its actions via nicotinic (nAChR) and muscarinic receptors. In the peripheral nervous system, ionotropic nAChR mediate responses in excitable cells. However, recent studies demonstrate the expression of nAChR in the colonic epithelium, which are coupled to an induction of Cl EXPERIMENTAL APPROACH: In order to find out whether these epithelial nAChR function as ionotropic receptors, intracellular microelectrode and imaging experiments were performed in isolated crypts from rat colon. Apically permeabilized epithelia were used to measure pump current across the basolateral membrane. KEY
resultsImaging experiments with the Na CONCLUSIONS AND IMPLICATIONS: These results suggest that epithelial nAChR activate the Na
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Registered trials
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