Evidence map›Paper›PMID 30808407›Full record

ReviewClinical epigenetics2019

The emerging role of epigenetics in human autoimmune disorders.

Roberta Mazzone, Clemens Zwergel, Marco Artico, Samanta Taurone, Massimo Ralli, Antonio Greco, Antonello Mai

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinical epigenetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 146 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
146citing papers in PubMed, 1 pooled it
11.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

146 citing papers in PubMed, 1 synthesis or guideline pooled it, 323 citations in OpenAlex.

  1. Pooled it
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  5. Review
  6. Narcolepsy is (not) an autoimmune disease.Nature reviews. Neurology · 2026
    Review
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86 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Roberta MazzoneDepartment of Chemistry and Technologies of Drugs, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy.
Clemens ZwergelDepartment of Chemistry and Technologies of Drugs, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy.
Marco ArticoDepartment of Sense Organs, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy.
Samanta TauroneIRCCS G.B. Bietti Foundation, Via Livenza, 3, 00198, Rome, Italy.
Massimo RalliDepartment of Sense Organs, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy.
Antonio GrecoDepartment of Sense Organs, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy.
Antonello MaiDepartment of Chemistry and Technologies of Drugs, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy. antonello.mai@uniroma1.it.ORCID 0000-0001-9176-2382
Sapienza University of Rome · ITFondazione G.B. Bietti · ITIstituto Pasteur · ITItalian Institute of Technology · IT

Funding

Histone Lysine deMethylation: Structures, Inhibitions and MechanismsR01GM114306 · NIGMS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI CHENG, XIAODONG · 2015 to 2018
$1.2M
NIGMS NIH HHS R01 GM114306
6 · The paper itself

Abstract

Epigenetic pathways play a pivotal role in the development and function of the immune system. Over the last decade, a growing body of studies has been published out seeking to explain a correlation between epigenetic modifications and the development of autoimmune disorders. Epigenetic changes, such as DNA methylation, histone modifications, and noncoding RNAs, are involved in the pathogenesis of autoimmune diseases mainly by regulating gene expression. This paper reviews the importance of epigenetic alterations during the development of the most prevalent human autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), systemic sclerosis (SSc), Sjogren's syndrome (SS), autoimmune thyroid diseases (AITD), and type 1 diabetes (T1D), aiming to provide new insights in the pathogenesis of autoimmune diseases and the possibility to develop novel therapeutic approaches targeting the epigenome.

Indexed as

Epigenesis, GeneticGene Regulatory NetworksAutoimmune DiseasesDNA MethylationGene Expression Regulation, NeoplasticHistone CodeHumansRNA, UntranslatedRNA, UntranslatedAutoimmune diseasesEpigenetic pathwaysEpigeneticsGene expression

Identifiers

PMID30808407
PMCPMC6390373
OpenAlexW2941821853

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.