Evidence map›Paper›PMID 30808661›Full record

ArticleGenes & development2019

Synaptotagmin-11 mediates a vesicle trafficking pathway that is essential for development and synaptic plasticity.

Masafumi Shimojo, Joseph Madara, Sandra Pankow, Xinran Liu, John Yates, Thomas C Südhof, Anton Maximov

Open access · diamondAbstract read
In one paragraph

Article in Genes & development, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it, 97 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Comprehensive characterization of the RNA editing landscape in the human aging brains with Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  8. Article
  9. Exosome: an overview on enhanced biogenesis by small molecules.Naunyn-Schmiedeberg's archives of pharmacology · 2025
    Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Role of SYT11 in human pan-cancer using comprehensive approaches.European journal of medical research · 2024
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Masafumi Shimojo *Department of Neuroscience, Scripps Research, La Jolla, California 92037, USA.
Joseph Madara *Department of Neuroscience, Scripps Research, La Jolla, California 92037, USA.
Sandra PankowDepartment of Molecular Medicine, Scripps Research, La Jolla, California 92037, USA.
Xinran LiuDepartment of Neuroscience, University of Texas Southwestern Medical Center at Dallas, Dallas 75235, Texas, USA.
John YatesDepartment of Molecular Medicine, Scripps Research, La Jolla, California 92037, USA.
Thomas C SüdhofDepartment of Neuroscience, University of Texas Southwestern Medical Center at Dallas, Dallas 75235, Texas, USA.
Anton MaximovDepartment of Neuroscience, Scripps Research, La Jolla, California 92037, USA.
Scripps Research Institute · USThe University of Texas Southwestern Medical Center · USScripps Health · USScripps Institution of Oceanography · USStanford University · US

Funding

Transcriptional Control of Synaptic Plasticity by Class IIa HDACsR01NS087026 · NINDS · SCRIPPS RESEARCH INSTITUTE, THE · PI MAXIMOV, ANTON · 2015 to 2024
$5.4M
Molecular Mechanisms Controlling Postsynaptic SecretionR01MH085776 · NIMH · SCRIPPS RESEARCH INSTITUTE, THE · PI MAXIMOV, ANTON · 2009 to 2013
$2.3M
Development of new methods for drug-inducible control of gene expression in model organismsR01GM117049 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI MAXIMOV, ANTON · 2017 to 2020
$1.7M
Transcriptional control of synaptic plasticity by class IIa HDACsR56NS087026 · NINDS · SCRIPPS RESEARCH INSTITUTE, THE · PI MAXIMOV, ANTON · 2014 to 2014
$474k
NIGMS NIH HHS R01 GM117049NIMH NIH HHS R01 MH085776NINDS NIH HHS R01 NS087026NINDS NIH HHS R56 NS087026
6 · The paper itself

Abstract

Synaptotagmin-11 (Syt11) is a Synaptotagmin isoform that lacks an apparent ability to bind calcium, phospholipids, or SNARE proteins. While human genetic studies have linked mutations in the

Indexed as

AnimalsCerebral CortexGene Expression ProfilingGene Expression Regulation, DevelopmentalGene Knock-In TechniquesHippocampusMemoryMiceMice, KnockoutNeuronal PlasticityNeuronsNeurotransmitter AgentsProsencephalonSynaptic PotentialsSynaptic TransmissionSynaptic VesiclesNeurotransmitter AgentsSynaptotagminsdevelopmentmembrane traffickingmemorymouse geneticsneuronsecretionsynaptic plasticitysynaptotagmin

Identifiers

PMID30808661
PMCPMC6411015
OpenAlexW2916607209

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.