Evidence map›Paper›PMID 30817168›Full record

ArticleAmerican journal of respiratory and critical care medicine2019

PFKFB3 in Smooth Muscle Promotes Vascular Remodeling in Pulmonary Arterial Hypertension.

Laszlo Kovacs, Yapeng Cao, Weihong Han, Louise Meadows, Anita Kovacs-Kasa, Dmitry Kondrikov, Alexander D Verin, Scott A Barman, Zheng Dong, Yuqing Huo and 1 more

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory and critical care medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 136 citations in OpenAlex.

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  15. Signaling pathways and targeted therapy for pulmonary hypertension.Signal transduction and targeted therapy · 2025
    Review
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17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Laszlo KovacsDepartment of Pharmacology and Toxicology.
Yapeng CaoVascular Biology Center.
Weihong HanDepartment of Pharmacology and Toxicology.
Louise MeadowsDepartment of Pharmacology and Toxicology.
Anita Kovacs-KasaVascular Biology Center.
Dmitry KondrikovDepartment of Pharmacology and Toxicology.
Alexander D VerinVascular Biology Center.
Scott A BarmanDepartment of Pharmacology and Toxicology.
Zheng DongDepartment of Cellular Biology and Anatomy, and.
Yuqing HuoVascular Biology Center.
Yunchao SuDepartment of Pharmacology and Toxicology.
Center for Vascular Biology Research · USAugusta University · USCharlie Norwood VA Medical Center · USLexington VA Health Care System · USPeking University · CN

Funding

PFKFB3 in vascular remodelingR01HL134934 · NHLBI · AUGUSTA UNIVERSITY · PI HUO, YUQING, SU, YUNCHAO · 2017 to 2020
$2.3M
Airway and Lung Vascular Remodeling in COPDI01BX002035 · VA · CHARLIE NORWOOD VA MEDICAL CENTER · PI SU, YUNCHAO · 2015 to 2018
–
BLRD VA I01 BX002035NHLBI NIH HHS R01 HL134934
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsCell ProliferationDisease Models, AnimalHumansMaleMiceMuscle, Smooth, VascularPhosphofructokinase-2Pulmonary Arterial HypertensionRatsVascular RemodelingPFKFB3 protein, humanPhosphofructokinase-2calpainextracellular signal–regulated kinaseglycolysisplatelet-derived growth factorvascular smooth muscle

Identifiers

PMID30817168
PMCPMC6727156
OpenAlexW2919709190

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.