ReviewCurrent opinion in anaesthesiology2019
Glucose control in the ICU.
Review in Current opinion in anaesthesiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed.
- Impact of tight glucose control on circulating 3-hydroxybutyrate in critically ill patients.Critical care (London, England) · 2021Trial
- Glycemic Status and Glycemic Variability Related to Mortality and Morbidity in Critically III Diabetic and Non-Diabetic Patients: A Prospective Observational Study.Clinics and practice · 2026Article
- Development and validation of glucose trajectory subphenotypes in critically ill patients on early enteral nutrition: a retrospective cohort study.Scientific reports · 2026Article
- A multiobjective optimization approach to data assimilation for complex biological systems with sparse data.Mathematical biosciences · 2026Article
- A Review on the Double Burden of Diabetes and Myocardial Infarction: Healthcare Challenges and Future Prospects in Low and Middle-Income Countries.Health science reports · 2025Article
- Explainable machine learning for predicting ICU mortality in myocardial infarction patients using pseudo-dynamic data.Scientific reports · 2025Article
- Modern-Day Therapeutics and Ongoing Clinical Trials against Type 2 Diabetes Mellitus: A Narrative Review.Current diabetes reviews · 2025Review
- Metabolic Disturbances Associated with In-Hospital Complication and Mortality in Different Types of Pneumonia.Journal of clinical medicine · 2024Article
- Admission Blood Glucose Associated with In-Hospital Mortality in Critically III Non-Diabetic Patients with Heart Failure: A Retrospective Study.Reviews in cardiovascular medicine · 2024Article
- Morbidities and mortality among hospitalized patients with hypopituitarism: Prevalence, causes and management.Reviews in endocrine & metabolic disorders · 2024Review
- Mean Blood Glucose Level During ICU Hospitalization is a Strong Predictor of the Mortality of COVID-19.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Hyperglycaemia and Its Prognostic Value in Patients with COVID-19 Admitted to the Hospital in Lithuania.Biomedicines · 2023Article
- Impact of critical illness on cholesterol and fatty acids: insights into pathophysiology and therapeutic targets.Intensive care medicine experimental · 2023Review
- The relationship between hyperglycaemia on admission and patient outcome is modified by hyperlactatemia and diabetic status: a retrospective analysis of the eICU collaborative research database.Scientific reports · 2023Article
- Kidney Dysfunction After Traumatic Brain Injury: Pathophysiology and General Management.Neurocritical care · 2023Review
- The association between hemoglobin A1c and all-cause mortality in the ICU: A cross-section study based on MIMIC-IV 2.0.Frontiers in endocrinology · 2023Article
- Effects of Endocrine Metabolic Factors on Hemocyte Parameters, Tumor Markers, and Blood Electrolytes in Patients with Hyperglycemia.Journal of diabetes research · 2023Article
- Paeoniflorin mitigates high glucose-induced lifespan reduction by inhibiting insulin signaling inFrontiers in pharmacology · 2023Article
- The Optimal Glycemic Control in Patients with Diabetes in the ICU: Where Is the Sweet Spot?American journal of respiratory and critical care medicine · 2022Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
purpose of reviewCritically ill patients usually develop hyperglycemia, which is associated with adverse outcome. Controversy exists whether the relationship is causal or not. This review summarizes recent evidence regarding glucose control in the ICU. RECENT
findingsDespite promising effects of tight glucose control in pioneer randomized controlled trials, the benefit has not been confirmed in subsequent multicenter studies and one trial found potential harm. This discrepancy could be explained by methodological differences between the trials rather than by a different case mix. Strategies to improve the efficacy and safety of tight glucose control have been developed, including the use of computerized treatment algorithms. SUMMARY: The ideal blood glucose target remains unclear and may depend on the context. As compared with tolerating severe hyperglycemia, tight glucose control is well tolerated and effective in patients receiving early parenteral nutrition when provided with a protocol that includes frequent, accurate glucose measurements and avoids large glucose fluctuations. All patient subgroups potentially benefit, with the possible exception of patients with poorly controlled diabetes, who may need less aggressive glucose control. It remains unclear whether tight glucose control is beneficial or not in the absence of early parenteral nutrition.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.