ReviewBiology of sex differences2019
Hormonal regulation of circuit function: sex, systems and depression.
Review in Biology of sex differences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 62 citations in OpenAlex.
- Physical frailty and the risk of peripheral vertigo: evidence from the UK Biobank cohort.Frontiers in neurology · 2026Article
- Age-dependent alterations in anterior cingulate excitation-inhibition balance in major depressive disorder revealed by 7-Tesla magnetic resonance spectroscopy.NeuroImage. Clinical · 2026Article
- Subtyping depression in the rheumatic diseases by cluster analysis.Clinical rheumatology · 2025Article
- Development and validation of a nomogram for predicting depression risk in patients with chronic kidney disease based on NHANES 2005-2018.Journal of health, population, and nutrition · 2025Article
- Global trends of depressive disorders among women of reproductive age from 1990 to 2021: a systematic analysis of burden, sociodemographic disparities, and health workforce correlations.BMC psychiatry · 2025Article
- A PRISMA Systematic Review of Sexual Dysfunction and Probiotics with Pathophysiological Mechanisms.Biology · 2025Review
- A predictive model for depression risk in individuals with hypertension: evidence from NHANES 2007-2020.BMC public health · 2025Article
- Regional variations and socioeconomic factors influencing sex hormone profiles in adolescent girls in Ghana.Frontiers in reproductive health · 2025Article
- A study on the differences in the gut microbiota and metabolism between male and female mice in different stress periods.Experimental biology and medicine (Maywood, N.J.) · 2025Article
- Sex hormones and serotonin 4 receptor brain binding in men with and without major depressive disorder.Neuroscience applied · 2025Article
- Do the Gender and the Number of Comorbidities and the Use of Tertiary Prevention Play a Role in the Severity of Anxiety and Depression in Patients with Coronary Artery Disease? A POLASPIRE II Study.Journal of clinical medicine · 2024Article
- Positive Effect of 6-Gingerol on Functional Plasticity of Microglia in a rat Model of LPS-induced Depression.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2024Article
- Article
- Sex Determines Anterior Cingulate Cortex Cortical Thickness in the Course of Depression.Biological psychiatry global open science · 2024Article
- Psychoneuroendocrine profiles of unmedicated men with major depressive disorder and associations to treatment effects and sexual side-effects.Neuroscience applied · 2024Article
- Prevalence and risk factors for depression and anxiety in patients with nasolacrimal duct obstruction.Frontiers in psychiatry · 2023Article
- Effect of total sleep deprivation on effective EEG connectivity for young male in resting-state networks in different eye states.Frontiers in neuroscience · 2023Article
- Smoking, health risks, coping mechanisms and depression in the age of COVID-19: A cross-sectional study of the Lebanese population.Journal of affective disorders reports · 2022Article
- Programming changes of hippocampal miR-134-5p/SOX2 signal mediate the susceptibility to depression in prenatal dexamethasone-exposed female offspring.Cell biology and toxicology · 2022Article
- Sex differences in comorbidities associated with Sjögren's disease.Frontiers in medicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Major depressive disorder (MDD) is a debilitating chronic illness that is two times more prevalent in women than in men. The mechanisms associated with the increased female susceptibility to depression remain poorly characterized. Aberrant neuronal oscillatory activity within the putative depression network is an emerging mechanism underlying MDD. However, innate sex differences in network activity and its contribution to depression vulnerability have not been well described. In this review, current evidence of sex differences in neuronal oscillatory activity, including the influence of sex hormones and female cycling, will first be described followed by evidence of disrupted neuronal circuit function in MDD and the effects of antidepressant treatment. Lastly, current knowledge of sex differences in MDD-associated aberrant circuit function and oscillatory activity will be highlighted, with an emphasis on the role of sex steroids and female cycling. Collectively, it is clear that there are significant gaps in the literature regarding innate and pathologically associated sex differences in network activity and that the elucidation of these differences is invaluable to our understanding of sex-specific vulnerabilities and therapies for MDD.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.