Evidence map›Paper›PMID 30820148›Full record

ArticleMolecular vision2019

Ocular phenotypic consequences of a single copy deletion of the

Soohyun Kim, Sara M Thomasy, Vijay Krishna Raghunathan, Leandro B C Teixeira, Ala Moshiri, Paul FitzGerald, Christopher J Murphy

Open access · greenAbstract read
In one paragraph

Article in Molecular vision, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.

  1. The Hippo signalling pathway and its impact on eye diseases.Journal of cellular and molecular medicine · 2024
    Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. TAZ (bioRxiv : the preprint server for biology · 2026
    Article
  6. Squishy matters - Corneal mechanobiology in health and disease.Progress in retinal and eye research · 2024
    Review
  7. Article
  8. Eyes open on stem cells.Stem cell reports · 2023
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Soohyun KimDepartment of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California Davis, Davis, CA.
Sara M ThomasyDepartment of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California Davis, Davis, CA.
Vijay Krishna RaghunathanDepartment of Basic Sciences, College of Optometry, University of Houston, Houston, TX.
Leandro B C TeixeiraComparative Ocular Pathology Laboratory of Wisconsin, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI.
Ala MoshiriDepartment of Ophthalmology & Vision Science, School of Medicine, School of Medicine, University of California Davis, Davis, CA.
Paul FitzGeraldDepartment of Ophthalmology & Vision Science, School of Medicine, School of Medicine, University of California Davis, Davis, CA.
Christopher J MurphyDepartment of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California Davis, Davis, CA.
University of California, Davis · USUniversity of Houston · USUniversity of Wisconsin–Madison · US

Funding

KOMP2-Phase3 Production and Phenotyping by the DTCC Consortium TCP Transfer to UC DavisUM1OD023221 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KC KENT LLOYD · 2016 to 2026
$45.7M
VISION RESEARCH CORE GRANTP30EY012576 · NEI · UNIVERSITY OF CALIFORNIA DAVIS · PI MARIE E BURNS · 1999 to 2026
$18.9M
Modulation of Signal Transduction by Nano-TopographyR01EY016134 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI MURPHY, CHRISTOPHER JOHN, THOMASY, SARA MICHELLE · 2006 to 2023
$5.1M
Biophysical Cues and Corneal Wound HealingR01EY019970 · NEI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MURPHY, CHRISTOPHER JOHN · 2011 to 2020
$3.5M
The Role of ARAP1 in Retinal Photoreceptor HomeostasisK08EY027463 · NEI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MOSHIRI, ALA · 2017 to 2021
$1.0M
NEI NIH HHS K08 EY027463NEI NIH HHS P30 EY012576NEI NIH HHS R01 EY016134NEI NIH HHS R01 EY019970NIH HHS UM1 OD023221
6 · The paper itself

Abstract

Purpose: To identify the effects of a single copy deletion of Methods: Complete ophthalmic examinations, as well as corneal esthesiometry, the phenol red thread test, intraocular pressure, and Fourier-domain optical coherence tomography were performed on Results: Microphthalmia with small palpebral fissures, corneal fibrosis, and reduced corneal sensation were common findings in the Conclusions: The results show that the heterozygous deletion of the

Indexed as

PhenotypeAdaptor Proteins, Signal TransducingAnimalsCataractCell Cycle ProteinsCorneal StromaDescemet MembraneEpithelium, CornealEye AbnormalitiesFemaleFibrosisGene ExpressionHeterozygoteIntraocular PressureIrisMaleAdaptor Proteins, Signal TransducingCell Cycle ProteinsPhosphoproteinsYap1 protein, mouseYAP-Signaling Proteins

Identifiers

PMID30820148
PMCPMC6382475
OpenAlexW2920653292

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.