Evidence map›Paper›PMID 30824537›Full record

ArticleThe Journal of biological chemistry2019

The proinflammatory cytokine TNFα induces DNA demethylation-dependent and -independent activation of

Zuodong Zhao, Mengying Lan, Jingjing Li, Qiang Dong, Xiang Li, Baodong Liu, Gang Li, Hailin Wang, Zhuqiang Zhang, Bing Zhu

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Mechanisms of chromatin-based epigenetic inheritance.Science China. Life sciences · 2022
    Review
  8. CGRP: A New Endogenous Cell Stemness Maintenance Molecule.Oxidative medicine and cellular longevity · 2022
    Review
  9. Deciphering DNA Methylation in HIV Infection.Frontiers in immunology · 2021
    Review
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Zuodong ZhaoFrom the Tsinghua University-Peking University-National Institute of Biological Sciences Joint Graduate Program, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Mengying Lanthe National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Jingjing Lithe National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Qiang Dongthe National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Xiang Lithe National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Baodong Liuthe State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
Gang Lithe Faculty of Health Sciences, University of Macau, Macau 999078, China.ORCID 0000-0003-3203-8567
Hailin Wangthe State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
Zhuqiang Zhangthe National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China, zhangzhuqiang@ibp.ac.cn.
Bing Zhuthe National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China, zhubing@ibp.ac.cn.
Chinese Academy of Sciences · CNUniversity of Macau · MO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

IL-32 is a cytokine involved in proinflammatory immune responses to bacterial and viral infections. However, the role of epigenetic events in the regulation of

Indexed as

CpG IslandsCyclic AMP Response Element-Binding ProteinDNA DemethylationGene SilencingHEK293 CellsHumansInflammation MediatorsInterleukinsNF-kappa BPromoter Regions, GeneticRegulatory Sequences, Nucleic AcidTranscription, GeneticTumor Necrosis Factor-alphaUp-RegulationCREB1 protein, humanCyclic AMP Response Element-Binding ProteinIL32 protein, humanInflammation MediatorsInterleukinsNF-kappa BTumor Necrosis Factor-alphaDNA demethylationDNA methylationepigeneticsgene activationgene regulationIL-32inflammationNF-κBTNFαtranscriptiontumor necrosis factor (TNF)

Identifiers

PMID30824537
PMCPMC6497958
OpenAlexW2920598557

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.