Evidence map›Paper›PMID 30832267›Full record

ArticleMolecules (Basel, Switzerland)2019

Multiple Targets of 3-Dehydroxyceanothetric Acid 2-Methyl Ester to Protect Against Cisplatin-Induced Cytotoxicity in Kidney Epithelial LLC-PK1 Cells.

Dahae Lee, Ki Hyun Kim, Won Yung Lee, Chang-Eop Kim, Sang Hyun Sung, Kyo Bin Kang, Ki Sung Kang

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Frontiers in physiology · 2025
    Article
  2. Article
  3. Article
  4. B Cell Lymphoma 2: A Potential Therapeutic Target for Cancer Therapy.International journal of molecular sciences · 2021
    Review
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Dahae LeeSchool of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea. pjsldh@naver.com.
Ki Hyun KimSchool of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea. khkim83@skku.edu.ORCID 0000-0002-5285-9138
Won Yung LeeCollege of Korean Medicine, Gachon University, Seongnam 13120, Korea. wonyung21@naver.com.ORCID 0000-0003-3902-3755
Chang-Eop KimCollege of Korean Medicine, Gachon University, Seongnam 13120, Korea. eopchang@gachon.ac.kr.
Sang Hyun SungCollege of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Korea. shsung@snu.ac.kr.ORCID 0000-0002-0527-4815
Kyo Bin KangCollege of Pharmacy, Sookmyung Women's University, Seoul 04310, Korea. kbkang@sookmyung.ac.kr.ORCID 0000-0003-3290-1017
Ki Sung KangCollege of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Korea. kkang@gachon.ac.kr.
Gachon University · KRSungkyunkwan University · KRSeoul National University · KRSookmyung Women's University · KR

Funding

National Research Foundation of Korea NRF-2017R1A2B2011807
6 · The paper itself

Abstract

Chronic exposure to cisplatin, a potent anticancer drug, causes irreversible kidney damage. In this study, we investigated the protective effect and mechanism of nine lupane- and ceanothane-type triterpenoids isolated from jujube (

Indexed as

AnimalsAntineoplastic AgentsApoptosisbcl-2-Associated X ProteinCaspase 3Caspase 8Cell SurvivalCisplatinGene Expression Regulation, NeoplasticHumansJNK Mitogen-Activated Protein KinasesKidneyKidney DiseasesLLC-PK1 CellsNeoplasmsp38 Mitogen-Activated Protein KinasesAntineoplastic Agentsbcl-2-Associated X ProteinCaspase 3Caspase 8ceanothaneCisplatinJNK Mitogen-Activated Protein Kinasesp38 Mitogen-Activated Protein KinasesProtective AgentsProto-Oncogene Proteins c-bcl-2TriterpenesapoptosiscisplatinMAPKsnephrotoxicity

Identifiers

PMID30832267
PMCPMC6429383
OpenAlexW2919253308

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.