ArticleDiabetes care2019
Importance of Treatment Status in Links Between Type 2 Diabetes and Alzheimer's Disease.
Article in Diabetes care, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- HIV, Vascular Risk Factors, and Cognition in the Combination Antiretroviral Therapy Era: A Systematic Review and Meta-Analysis.Journal of the International Neuropsychological Society : JINS · 2021Pooled it
- Brain pathology in relation to somatic diseases: Exploring the body-brain crosstalk.Journal of internal medicine · 2026Review
- Diabetes, prediabetes, and mild cognitive impairment among older adults: the Hitachi Health Study II.Acta diabetologica · 2026Article
- Disentangling treatment status from disease severity in studies of diabetes and Alzheimer's disease biomarkers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Diabetes, hyperglycemia, and ATN blood biomarkers in Hispanic/Latino populations: SOL-INCA study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Association of type 2 diabetes treatment status with in vivo biomarkers of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- The association of diabetes with Alzheimer's disease biomarkers and vascular burden across European aging and memory clinic cohorts.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Diabetes status, duration and risk of dementia in patients with myocardial infarction.Diabetology & metabolic syndrome · 2025Article
- Alterations in cerebral perfusion and substrate metabolism in type 2 diabetes: interactions with APOE-ε4.Diabetologia · 2025Article
- Predictors of Cognitive Decline in Alzheimer's Disease: A Longitudinal Bayesian Analysis.Medicina (Kaunas, Lithuania) · 2025Article
- Individualized treatment of diabetes mellitus in older adults.Geriatrics & gerontology international · 2024Review
- Plasma Biomarkers of Brain Injury and Their Association With Brain MRI and Cognition in Type 1 Diabetes.Diabetes care · 2024Article
- APOE ε4 carrier status modifies plasma p-tau181 concentrations in cognitively healthy super-seniors.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Novel targets and therapies of metformin in dementia: old drug, new insights.Frontiers in pharmacology · 2024Review
- Diabetes and cognitive decline: Challenges and future direction.World journal of diabetes · 2023Review
- The relationship of insulin resistance and diabetes to tau PET SUVR in middle-aged to older adults.Alzheimer's research & therapy · 2023Article
- How does apolipoprotein E genotype influence the relationship between physical activity and Alzheimer's disease risk? A novel integrative model.Alzheimer's research & therapy · 2023Review
- Type 2 Diabetes Mellitus, Platelet Activation and Alzheimer's Disease: A Possible Connection.Clinical neuropsychiatry · 2022Article
- Evaluating the efficacy and mechanism of metformin targets on reducing Alzheimer's disease risk in the general population: a Mendelian randomisation study.Diabetologia · 2022Article
- Association between Type 2 Diabetes Mellitus and Brain Atrophy: A Meta-Analysis (Diabetes Metab J 2022;46:781-802).Diabetes & metabolism journal · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo investigate relationships among type 2 diabetes treatment, Alzheimer's disease(AD) biomarkers, and risk for dementia. RESEARCH DESIGN AND
methodsParticipants were from the Alzheimer's Disease Neuroimaging Initiative (
resultsThe UD group displayed greater p-tau, t-tau, and p-tau/Aβ1-42 levels than the EU, PD, and TD groups (
conclusionsTreatment status may alter the relationship between type 2 diabetes and both AD biomarker profile and risk for dementia. UD is associated with elevated tau pathology and risk for dementia, whereas TD is not. Although this study is observational and therefore causality cannot be inferred, findings support the potential importance of treatment status in AD risk associated with type 2 diabetes.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.