ArticleScientific reports2019
Microbial Colonization Coordinates the Pathogenesis of a Klebsiella pneumoniae Infant Isolate.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 37 citations in OpenAlex.
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- Genome-scale CRISPR/Cas9 screening reveals the role ofmSphere · 2025Article
- The Influence of Microorganisms on the Onset and Development of Colorectal Cancer in Humans: A Descriptive Cross-Reference Study.Life (Basel, Switzerland) · 2025Article
- Deciphering the gastrointestinal carriage ofInfection and immunity · 2024Review
- Antimicrobial resistance profiles and genome characteristics ofJournal of medical microbiology · 2024Article
- The Roles of a Multidrug-ResistantAntibiotics (Basel, Switzerland) · 2024Article
- Gut-resident microorganisms and their genes are associated with cognition and neuroanatomy in children.Science advances · 2023Article
- Hypermucoviscous Carbapenem-ResistantInternational journal of molecular sciences · 2023Article
- Loss of symbiotic and increase of virulent bacteria through microbial networks in Lynch syndrome colon carcinogenesis.Frontiers in oncology · 2023Article
- Epidemiological Analysis of Extended-Spectrum β-Lactamase-ProducingAntibiotics (Basel, Switzerland) · 2022Article
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- Amoxicillin impact on pathophysiology induced by short term high salt diet in mice.Scientific reports · 2022Article
- Amoxicillin modulates gut microbiota to improve short-term high-fat diet induced pathophysiology in mice.Gut pathogens · 2022Article
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- The gut fungal and bacterial microbiota in pediatric patients with inflammatory bowel disease introduced to treatment with anti-tumor necrosis factor-α.Scientific reports · 2022Article
- Bacteriophage-mediated manipulations of microbiota in gastrointestinal diseases.Frontiers in microbiology · 2022Review
- The role of oral bacteria in inflammatory bowel disease.Nature reviews. Gastroenterology & hepatology · 2021Review
- FromMicroorganisms · 2021Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Enterobacteriaceae are among the first colonizers of neonate intestine. Members of this family, such as Escherichia and Klebsiella, are considered pathobionts and as such are capable of inducing local and systemic disease under specific colonization circumstances. Interplay between developing microbiota and pathogenic function of pathobionts are poorly understood. In this study, we investigate the functional interaction between various colonization patterns on an early colonizer, K. pneumoniae. K. pneumoniae 51-5 was isolated from stool of a healthy, premature infant, and found to contain the genotoxin island pks associated with development of colorectal cancer. Using intestinal epithelial cells, macrophages, and primary splenocytes, we demonstrate K. pneumoniae 51-5 upregulates expression of proinflammatory genes in vitro. Gnotobiotic experiments in Il10
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.