Evidence map›Paper›PMID 30837270›Full record

ArticleThe Journal of biological chemistry2019

Proteomic analysis reveals that wildtype and alanine-expanded nuclear poly(A)-binding protein exhibit differential interactions in skeletal muscle.

Ayan Banerjee, Brittany L Phillips, Quidong Deng, Nicholas T Seyfried, Grace K Pavlath, Katherine E Vest, Anita H Corbett

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ayan BanerjeeFrom the Department of Biology and.
Brittany L PhillipsFrom the Department of Biology and.
Quidong Dengthe Department of Biochemistry, Center for Neurodegenerative Diseases and.
Nicholas T Seyfriedthe Department of Biochemistry, Center for Neurodegenerative Diseases and.
Grace K Pavlaththe Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, and.
Katherine E Vestthe Department of Molecular Genetics, Biochemistry & Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 katherine.vest@uc.edu.
Anita H CorbettFrom the Department of Biology and acorbe2@emory.edu.
Emory University · USUniversity of Cincinnati Medical Center · US

Funding

Muscle-Specific Basis of OPMDR01AR061987 · NIAMS · EMORY UNIVERSITY · PI CORBETT, ANITA H. · 2011 to 2021
$3.4M
Myogenesis and RNA Biogenesis in a Mouse Model of OPMDF32AR068207 · NIAMS · EMORY UNIVERSITY · PI VEST, KATHERINE ELIZABETH · 2016 to 2018
$150k
NIAMS NIH HHS F32 AR068207NIAMS NIH HHS R01 AR061987
6 · The paper itself

Abstract

Oculopharyngeal muscular dystrophy (OPMD) is a late-onset, primarily autosomal dominant disease caused by a short GCN expansion in the

Indexed as

ProteomicsAlanineAnimalsCells, CulturedDNA-Binding ProteinsElectroporationFemaleMaleMiceMolecular WeightMuscle, SkeletalMuscular Dystrophy, OculopharyngealNuclear ProteinsPoly(A)-Binding Protein IProof of Concept StudyProtein BindingAlanineDNA-Binding ProteinsNuclear ProteinsPABPN1 protein, mousePoly(A)-Binding Protein ITardbp protein, mousegene regulationmuscular dystrophyoculopharyngeal muscular dystrophy (OPMD)PABPN1poly(A) polyalanine tractprotein aggregationprotein–protein interactionproteomicsRNA-binding proteinskeletal muscleTAR DNA-binding protein 43 (TDP-43) (TARDBP)

Identifiers

PMID30837270
PMCPMC6509510
OpenAlexW2919046009

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.