Evidence map›Paper›PMID 30838213›Full record

ArticleFrontiers in cardiovascular medicine2019

After 50 Years of Heart Transplants: What Does the Next 50 Years Hold for Cardiovascular Medicine? A Perspective From the International Society for Applied Cardiovascular Biology.

Joshua D Hutcheson, Craig J Goergen, Frederick J Schoen, Masanori Aikawa, Peter Zilla, Elena Aikawa, Glenn R Gaudette

Abstract read
In one paragraph

Article in Frontiers in cardiovascular medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Joshua D HutchesonDepartment of Biomedical Engineering, Florida International University, Miami, FL, United States.
Craig J GoergenWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United States.
Frederick J SchoenBrigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Masanori AikawaBrigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Peter ZillaChris Barnard Division of Cardiothoracic Surgery, University of Cape Town, Cape Town, South Africa.
Elena AikawaBrigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Glenn R GaudetteWorcester Polytechnic Institute, Worcester, MA, United States.

Funding

Improving Mitral Compensation In Ischemic RegurgitationR01HL141917 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI AIKAWA, ELENA, BISCHOFF, JOYCE E. · 2018 to 2021
$5.6M
Macrophage-derived microcalcificaitonsR01HL136431 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI AIKAWA, ELENA · 2017 to 2020
$2.7M
PARP9 and PARP14 in atherosclerosisR01HL126901 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI AIKAWA, MASANORI · 2016 to 2019
$2.4M
Dll4 in macrophage activationR01HL107550 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI AIKAWA, MASANORI · 2012 to 2015
$2.1M
Biological sutures to enhance progenitor cell delivery and retention in the heartR01HL115282 · NHLBI · WORCESTER POLYTECHNIC INSTITUTE · PI GAUDETTE, GLENN R · 2013 to 2017
$1.9M
NHLBI NIH HHS R01 HL107550NHLBI NIH HHS R01 HL115282NHLBI NIH HHS R01 HL126901NHLBI NIH HHS R01 HL136431NHLBI NIH HHS R01 HL141917
6 · The paper itself

Abstract

The first successful heart transplant 50 years ago by Dr.Christiaan Barnard in Cape Town, South Africa revolutionized cardiovascular medicine and research. Following this procedure, numerous other advances have reduced many contributors to cardiovascular morbidity and mortality; yet, cardiovascular disease remains the leading cause of death globally. Various unmet needs in cardiovascular medicine affect developing and underserved communities, where access to state-of-the-art advances remain out of reach. Addressing the remaining challenges in cardiovascular medicine in both developed and developing nations will require collaborative efforts from basic science researchers, engineers, industry, and clinicians. In this perspective, we discuss the advancements made in cardiovascular medicine since Dr. Barnard's groundbreaking procedure and ongoing research efforts to address these medical issues. Particular focus is given to the mission of the International Society for Applied Cardiovascular Biology (ISACB), which was founded in Cape Town during the 20th celebration of the first heart transplant in order to promote collaborative and translational research in the field of cardiovascular medicine.

Indexed as

aortic valvearterial diseasecardiovascular medicineheart transplantinterdisciplinary/multidisciplinarymyocardial regenerationtissue engineeering

Identifiers

PMID30838213
PMCPMC6382669

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.