Evidence map›Paper›PMID 30841507›Full record

ArticleViruses2019

Inclusion of Antibodies to Cell Culture Media Preserves the Integrity of Genes Encoding RL13 and the Pentameric Complex Components During Fibroblast Passage of Human Cytomegalovirus.

Amine Ourahmane, Xiaohong Cui, Li He, Meaghan Catron, Dirk P Dittmer, Ahmed Al Qaffasaa, Mark R Schleiss, Laura Hertel, Michael A McVoy

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Human herpesvirus diversity is altered in HLA class I binding peptides.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  4. Article
  5. Immune Prophylaxis and Therapy for Human Cytomegalovirus Infection.International journal of molecular sciences · 2021
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Amine OurahmaneVirginia Commonwealth University, Richmond, VA 23298, USA. ourahmanea@mymail.vcu.edu.
Xiaohong CuiVirginia Commonwealth University, Richmond, VA 23298, USA. xiaorobin06@yahoo.com.
Li HeVirginia Commonwealth University, Richmond, VA 23298, USA. hel3@mymail.vcu.edu.
Meaghan CatronVirginia Commonwealth University, Richmond, VA 23298, USA. catronme@mymail.vcu.edu.
Dirk P DittmerDepartment of Microbiology and Immunology, Lineberger Comprehensive Cancer Center Program in Global Oncology, Center for AIDS Research (CfAR), School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. dirk_dittmer@med.unc.edu.
Ahmed Al QaffasaaVirginia Commonwealth University, Richmond, VA 23298, USA. alqaffasaa@mymail.vcu.edu.
Mark R SchleissCenter for Infectious Diseases and Microbiology Translational Research, Division of Pediatric Infectious Diseases, Minneapolis, MN 55455, USA. schleiss@umn.edu.
Laura HertelChildren's Hospital Oakland Research Institute, Oakland, CA 94609, USA. lhertel@chori.org.
Michael A McVoyVirginia Commonwealth University, Richmond, VA 23298, USA. michael.mcvoy@vcuhealth.org.
Virginia Commonwealth University · USUniversity of North Carolina at Chapel Hill · US

Funding

Vironomics and Biostatistics CoreP01CA019014 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BLOSSOM A DAMANIA, NANCY JOAN RAAB-TRAUB · 1985 to 2026
$43.8M
Preclinical development of human CMV vaccinesR01AI088750 · NIAID · VIRGINIA COMMONWEALTH UNIVERSITY · PI MCVOY, MICHAEL A · 2010 to 2014
$3.9M
Cytomegalovirus Tropisms for Oral Cells: Key to a Vaccine to Prevent Maternal InfectionR01AI128912 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HERTEL, LAURA, MCVOY, MICHAEL A · 2017 to 2020
$2.0M
Optimized Vaccines Against Congenital Infection and Maternal Reinfection with CMVR01HD079918 · NICHD · UNIVERSITY OF MINNESOTA · PI SCHLEISS, MARK R. · 2015 to 2019
$1.6M
Ability of CMV Vaccines to Induce Antibodies that Block Endocytic EntryR21AI073615 · NIAID · VIRGINIA COMMONWEALTH UNIVERSITY · PI MCVOY, MICHAEL A · 2008 to 2009
$389k
NIAID NIH HHS R01 AI088750NIAID NIH HHS R01 AI128912NIAID NIH HHS R21 AI073615NICHD NIH HHS R01 HD079918
6 · The paper itself

Abstract

Propagation of human cytomegalovirus (CMV) in cultured cells results in genetic adaptations that confer improved growth in vitro and significant attenuation in vivo. Mutations in

Indexed as

Antibodies, ViralCell Culture TechniquesCell LineCulture MediaCytomegalovirusFibroblastsHumansInfant, NewbornMutationViral ProteinsViral TropismVirus InternalizationVirus ReplicationAntibodies, ViralCulture MediaViral Proteinsadaptationantibodiescell culturecytomegalovirus

Identifiers

PMID30841507
PMCPMC6466449
OpenAlexW2890459556

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.