Evidence map›Paper›PMID 30843304›Full record

SynthesisJournal of clinical laboratory analysis2019

Prevalence of Hepatitis C virus genotypes in nine selected European countries: A systematic review.

Arnolfo Petruzziello, Giovanna Loquercio, Rocco Sabatino, Daniel Vasile Balaban, Najeeb Ullah Khan, Mauro Piccirillo, Luis Rodrigo, Lucia di Capua, Annunziata Guzzo, Francesco Labonia and 1 more

Abstract readSystematic Review
In one paragraph

Synthesis in Journal of clinical laboratory analysis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Genotype 3-hepatitis C virus' last line of defense.World journal of gastroenterology · 2021
    Review
  9. Article
  10. PDCD1 and IFNL4 genetic variants and risk of developing hepatitis C virus-related diseases.Liver international : official journal of the International Association for the Study of the Liver · 2021
    Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Arnolfo PetruzzielloUOC Clinical Pathology, AORN Sant'Anna e San Sebastiano, Caserta, Italy.ORCID https://orcid.org/0000-0003-0353-9151
Giovanna LoquercioSSD Virology and Molecular Biology, Department of Diagnostic Area, Istituto Nazionale Tumori - Fondazione "G. Pascale", IRCCS Italia, Naples, Italy.
Rocco SabatinoSSD Virology and Molecular Biology, Department of Diagnostic Area, Istituto Nazionale Tumori - Fondazione "G. Pascale", IRCCS Italia, Naples, Italy.
Daniel Vasile BalabanCarol Davila" University of Medicine and Pharmacy, "Dr. Carol Davila" Central Military Emergency University Hospital, Bucharest, Romania.ORCID https://orcid.org/0000-0003-3436-8041
Najeeb Ullah KhanInstitute of Biotechnology and Genetic Engineering (Health Davison), The University of Agriculture, Peshawar, Pakistan.
Mauro PiccirilloHepatobiliar and Pancreatic Unit, Department of Surgical Oncology, Istituto Nazionale Tumori-Fondazione "G. Pascale", IRCCS Italia, Naples, Italy.
Luis RodrigoGastroenterology Service, Hospital Universitario Central de Asturias, University of Oviedo, Oviedo, Spain.
Lucia di CapuaSSD Virology and Molecular Biology, Department of Diagnostic Area, Istituto Nazionale Tumori - Fondazione "G. Pascale", IRCCS Italia, Naples, Italy.
Annunziata GuzzoSSD Virology and Molecular Biology, Department of Diagnostic Area, Istituto Nazionale Tumori - Fondazione "G. Pascale", IRCCS Italia, Naples, Italy.
Francesco LaboniaSSD Virology and Molecular Biology, Department of Diagnostic Area, Istituto Nazionale Tumori - Fondazione "G. Pascale", IRCCS Italia, Naples, Italy.
Gerardo BottiScientific Director, IRCCS Fondazione Pascale, Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHepatitis C virus (HCV) infection is a global health problem especially for its increasing level of mortality. Detailed knowledge of HCV genotypes prevalence has clinical relevance since the efficacy of therapies is impacted by genotypes and subtypes distribution. Moreover, HCV exhibits a great genetic variability regionally. To date, there are no published studies assessing HCV genotypes distribution in specific countries of the Mediterranean basin. The aim of this study was to review data published from 2000 to 2017 with the purpose to estimate genotypes distribution of HCV infection in nine European countries all located in the Mediterranean basin.

methodsA systematic research of peer-reviewed journals indexed in PubMed, Scopus, and EMBASE databases selected if containing data regarding distribution of HCV genotypes in nine selected European countries (Albania, Bosnia, Croatia, France, Greece, Italy, Montenegro, Slovenia, and Spain) was performed.

resultsGenotype 1 is the most common (61.0%), ranging from 80.0% in Croatia to 46.0% in Greece, followed by genotype 3 (20.0%), varying from 38.0% in Slovenia to 7.0% and 8.0%, respectively, in Italy and in Albania and by genotype 4 (10.0%) that shows an increase of 1.1% with respect to data obtained till 2014 probably due to the increasing migrants arrivals to Southern Europe. G2, the fourth most frequent genotype (8.5%), particularly common in Italy (27.0%) and Albania (18.0%) might be probably introduced in Southern Italy as a result of Albanian campaign during Second World War and more and more increased by the migration flows from Albania to Italy in the 90s.

conclusionEpidemiology of HCV infection shows a high variability across the European countries that border the Mediterranean Sea. HCV genotyping is a relevant tool to monitor the dynamic process influenced by both evolving transmission trends and new migration flows on HCV scenario.

Indexed as

EuropeGenotypeHepacivirusHepatitis CHumansMediterranean RegionPrevalenceepidemiologyHCV genotypeHCV infectionHCV prevalenceHepatitis C virus

Identifiers

PMID30843304
PMCPMC6595292

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.