Evidence map›Paper›PMID 30843600›Full record

ArticleClinical and experimental immunology2019

Cellular immunological changes in patients with LADA are a mixture of those seen in patients with type 1 and type 2 diabetes.

K Singh, M Martinell, Z Luo, D Espes, J Stålhammar, S Sandler, P-O Carlsson

Open access · hybridAbstract read
In one paragraph

Article in Clinical and experimental immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Latent autoimmune diabetes in youth.Frontiers in immunology · 2025
    Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Latent autoimmune diabetes in adults in China.Frontiers in immunology · 2022
    Review
  13. Innate immunity in latent autoimmune diabetes in adults.Diabetes/metabolism research and reviews · 2022
    Review
  14. Review
  15. Review
  16. Article
  17. Interleukin-35: Structure, Function and Its Impact on Immune-Related Diseases.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2021
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

K SinghDepartment of Medical Cell Biology, Uppsala University, Uppsala, Sweden.ORCID 0000-0002-6771-7757
M MartinellDepartment of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.
Z LuoDepartment of Medical Cell Biology, Uppsala University, Uppsala, Sweden.
D EspesDepartment of Medical Cell Biology, Uppsala University, Uppsala, Sweden.
J StålhammarDepartment of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.
S SandlerDepartment of Medical Cell Biology, Uppsala University, Uppsala, Sweden.
P-O CarlssonDepartment of Medical Cell Biology, Uppsala University, Uppsala, Sweden.
Uppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is currently scarce knowledge of the immunological profile of patients with latent autoimmune diabetes mellitus in the adult (LADA) when compared with healthy controls (HC) and patients with classical type 1 diabetes (T1D) and type 2 diabetes (T2D). The objective of this study was to investigate the cellular immunological profile of LADA patients and compare to HC and patients with T1D and T2D. All patients and age-matched HC were recruited from Uppsala County. Peripheral blood mononuclear cells were isolated from freshly collected blood to determine the proportions of immune cells by flow cytometry. Plasma concentrations of the cytokine interleukin (IL)-35 were measured by enzyme-linked immunosorbent assay (ELISA). The proportion of CD11c

Indexed as

Immunity, CellularAdaptive ImmunityAdultAgedAntigen-Presenting CellsB-Lymphocytes, RegulatoryCase-Control StudiesDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2FemaleHumansImmunity, InnateInterleukinsKiller Cells, NaturalLatent Autoimmune Diabetes in AdultsMaleinterleukin-35, humanInterleukinsCellular immunologyIL-35LADAtype 1 diabetestype 2 diabetes

Identifiers

PMID30843600
PMCPMC6591143
OpenAlexW2922007696

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.