Trial reportPloS one2019
High-resolution contrast-enhanced vessel wall imaging in patients with suspected cerebral vasculitis: Prospective comparison of whole-brain 3D T1 SPACE versus 2D T1 black blood MRI at 3 Tesla.
Trial report in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Vessel wall MR imaging of central nervous system vasculitis: a systematic review.Neuroradiology · 2022Pooled it
- Spatial Distribution of Intracranial Vessel Wall Enhancement in Hypertension and Primary Angiitis of the CNS.Scientific reports · 2019Trial
- Primary central nervous system vasculitis: an update.Journal of neurology · 2026Review
- Quantitative ASL Perfusion and Vessel Wall MRI in Tuberculous Meningitis: A Pre- and Post-Treatment Study.Journal of clinical medicine · 2026Article
- Review
- T1 Relaxation-Enhanced Steady-State Acquisition With Radial k-Space Sampling: A Novel Family of Pulse Sequences for Motion-Robust Volumetric T1-Weighted MRI With Improved Lesion Conspicuity.Investigative radiology · 2025Article
- 7T MRI as a Powerful Tool to Detect Small- and Medium-Size Vessel CNS Vasculitis.AJNR. American journal of neuroradiology · 2025Article
- Dark Blood Contrast-Enhanced Brain MRI Using Echo-uTJournal of magnetic resonance imaging : JMRI · 2024Article
- Assessment of central nervous system vasculitis in children based on high-resolution vascular wall imaging.Rheumatology advances in practice · 2024Article
- Multimodality Imaging in Cranial Giant Cell Arteritis: First Experience with High-Resolution T1-Weighted 3D Black Blood without Contrast Enhancement Magnetic Resonance Imaging.Diagnostics (Basel, Switzerland) · 2023Article
- Neuroimaging Scoring Tools to Differentiate Inflammatory Central Nervous System Small-Vessel Vasculitis: A Need for Artificial Intelligence/Machine Learning?-A Scoping Review.Tomography (Ann Arbor, Mich.) · 2023Article
- Best Practice Recommendations for Stroke Vascular Imaging During Iodinated Contrast Shortage.Neurology. Clinical practice · 2023Article
- Feasibility of 3D T1W sequences in contrast-material enhanced MR cisternography at 3T.Turkish journal of medical sciences · 2022Article
- Vessel Wall Magnetic Resonance Imaging in Cerebrovascular Diseases.Diagnostics (Basel, Switzerland) · 2022Review
- Vessel wall magnetic resonance and arterial spin labelling imaging in the management of presumed inflammatory intracranial arterial vasculopathy.Brain communications · 2022Article
- Usefulness of 3D High-resolution Vessel Wall MRI in Diffuse Nonaneurysmal SAH Patients.Clinical neuroradiology · 2021Article
- High-resolution Compressed-sensing T1 Black-blood MRI : A New Multipurpose Sequence in Vascular Neuroimaging?Clinical neuroradiology · 2021Article
- High-Resolution MRI Vessel Wall Imaging in Acute Aneurysmal Subarachnoid Hemorrhage : Spatiotemporal Pattern and Clinicoradiologic Implications.Clinical neuroradiology · 2020Article
- Magnetic Resonance Vessel Wall Imaging in Central Nervous System Vasculitides: A Case Series.The neurologist · 2020Article
- Vessel wall MR imaging of intracranial atherosclerosis.Cardiovascular diagnosis and therapy · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeVessel wall imaging (VWI) using T1 dark blood MRI can depict inflammation of intracranial arteries in patients with cerebral vasculitis. Recently, 3D VWI sequences were introduced at 3 Tesla. We aimed to compare 2D and 3D VWI for detection of intracranial vessel wall enhancement (VWE) in patients suspected of cerebral vasculitis.
methods44 MRI scans of 39 patients were assessed that included bi-planar 2D T1 and whole-brain 3D T1 SPACE dark blood VWI pre and post contrast. Visibility and VWE were analyzed in 31 pre-specified intracranial artery segments. Additionally, leptomeningeal and parenchymal contrast enhancement was assessed.
resultsOverall, more arterial segments were visualized with 3D VWI (p<0.0001). Detection of VWE showed fair agreement between 2D and 3D VWI (κ = 0.583). On segmental level, more VWE was detected in intradural ICA by 2D VWI (p<0.001) and in VA V4 segment by 3D VWI (p<0.05). 3D VWI showed more leptomeningeal (p<0.05) and parenchymal (p<0.01) contrast enhancement. In patients with positive diagnosis of cerebral vasculitis, sensitivity was of 67% (2D and 3D VWI) and specificity was 44% (2D VWI) and 48% (3D VWI); more VWE was seen in arteries distal to VA and ICA compared to non-vasculitic patients.
conclusion2D and 3D VWI differed in the ability to detect VWE. Whole brain coverage with better evaluability of VAs and distal intracranial artery segments, and depiction of more parenchymal and leptomeningeal enhancement make 3D VWI more favorable. As VWE in arteries distal to VA and ICA may be used for discrimination of vasculitic and non-vasculitic patients, future increase in spatial resolution of 3D VWI sequences may be beneficial.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.