ArticleInternational journal of molecular sciences2019
Urinary Metabolites Altered during the Third Trimester in Pregnancies Complicated by Gestational Diabetes Mellitus: Relationship with Potential Upcoming Metabolic Disorders.
Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Early pregnancy biomarkers for gestational diabetes mellitus prediction: a systematic review and meta-analysis of routine laboratory, metabolic, and inflammatory markers.Frontiers in endocrinology · 2026Pooled it
- Review
- The placental tryptophan pathway across gestation: implications for pregnancy outcomes.Human reproduction update · 2026Review
- Urinary Metabolites during Pregnancy: A Literature Review.ACS nutrition science · 2026Review
- Gestational age and models for predicting gestational diabetes mellitus.Metabolomics : Official journal of the Metabolomic Society · 2025Observational
- Is there any difference between metabolomic profiles of mothers who progress to gestational diabetes versus healthy women during pregnancy?Journal of diabetes and metabolic disorders · 2024Article
- The Effect of Oxidative Stress and Antioxidants Treatment on Gestational Diabetes Mellitus Outcome: A Scoping Review.Cell biochemistry and biophysics · 2024Article
- Article
- Risk Estimation of Gestational Diabetes Mellitus in the First Trimester.The Journal of clinical endocrinology and metabolism · 2023Article
- Biochemical and molecular biomarkers: unraveling their role in gestational diabetes mellitus.Diabetology & metabolic syndrome · 2023Review
- Urine and Serum Metabolomic Profiles Differ by Disease Activity in Pregnant Women With Inflammatory Bowel Diseases.Gastro hep advances · 2022Article
- A diagnostic model for overweight and obesity from untargeted urine metabolomics of soldiers.PeerJ · 2022Article
- Establishment of clinical diagnostic models using glucose, lipid, and urinary polypeptides in gestational diabetes mellitus.Journal of clinical laboratory analysis · 2021Article
- Associations of Arginine with Gestational Diabetes Mellitus in a Follow-Up Study.International journal of molecular sciences · 2020Article
- Placental exosomes isolated from urine of patients with gestational diabetes exhibit a differential profile expression of microRNAs across gestation.International journal of molecular medicine · 2020Article
- Metabolic Dynamics and Prediction of Gestational Age and Time to Delivery in Pregnant Women.Cell · 2020Article
- Assessing Urinary Metabolomics in Giant Pandas Using Chromatography/Mass Spectrometry: Pregnancy-Related Changes in the Metabolome.Frontiers in endocrinology · 2020Article
- Predictive and diagnostic biomarkers for gestational diabetes and its associated metabolic and cardiovascular diseases.Cardiovascular diabetology · 2019Review
- Lipid Metabolism Alterations in a Rat Model of Chronic and Intergenerational Exposure to Arsenic.BioMed research international · 2019Article
- Understanding glycaemic control and current approaches for screening antidiabetic natural products from evidence-based medicinal plants.Plant methods · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Gestational diabetes mellitus (GDM) is a disorder in pregnancy with highest impact in the future life of both mother and newborn. Increasing incidence, economic impact, and potential for severe GDM-related pregnancy complications are some factors that have motivated the deep study of physiopathology, risk factors for developing GDM, and potential biomarkers for its diagnosis. In the present pilot study, we analyzed the urinary metabolome profile of GDM patients in the 3rd trimester of pregnancy, when GDM is already established and the patients are under dietary and pharmacological control. An untargeted metabolomics method based on liquid chromatography⁻mass spectrometry analysis was developed to identify differentially expressed metabolites in the GDM group. We identified 14 metabolites that are significantly upregulated in the urine of GDM patients, and, more importantly, we identified those related with the steroid hormone biosynthesis and tryptophan (TRP) metabolism pathways, which are associated with GDM pathophysiology. Thus, these metabolites could be screened as potential prognostic biomarkers of type two diabetes mellitus, coronary artery disease and chronic renal failure in future follow-up studies with GDM patients.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.