Evidence map›Paper›PMID 30860881›Full record

ArticleAmerican journal of physiology. Endocrinology and metabolism2019

A novel measure of glucose homeostasis (or loss thereof) comprising the joint dynamics of glucose, insulin, glucagon, and cortisol.

Daniel M Keenan, Johannes D Veldhuis, Ananda Basu, Rita Basu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Endocrinology and metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Recent research trends in voltammetric sensing platforms for hormones and their applications to human serum analyses.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Daniel M KeenanDepartment of Statistics, University of Virginia , Charlottesville, Virginia.
Johannes D VeldhuisDepartment of Medicine, Endocrine Research Unit, Mayo School of Graduate Medical Education, Clinical Translational Science Center, Mayo Clinic , Rochester, Minnesota.
Ananda BasuDivision of Endocrinology, Center of Diabetes Technology, University of Virginia School of Medicine , Charlottesville, Virginia.
Rita BasuDivision of Endocrinology, Center of Diabetes Technology, University of Virginia School of Medicine , Charlottesville, Virginia.

Funding

NIDDK NIH HHS R01 DK085516
6 · The paper itself

Abstract

Quantification of disturbances in glucose-insulin homeostasis has been the cornerstone of appraising insulin resistance and detecting early-stage diabetes. Metabolic homeostasis arises from feedback and feed-forward interactions among (at least) all four of glucose, insulin, glucagon, and cortisol. Quantifying such tetrapartite interactions in the fasting (endogenously regulated) state overnight could elucidate very early regulatory disruption. In the present study, healthy subjects without diabetes (ND;

Indexed as

Blood GlucoseCase-Control StudiesDiabetes Mellitus, Type 2GlucagonHomeostasisHumansHydrocortisoneInsulinInsulin ResistanceInsulin SecretionPrediabetic StateBlood GlucoseGlucagonHydrocortisoneInsulindeconvolutiondiabetesinsulin resistancesecretion

Identifiers

PMID30860881
PMCPMC6620575

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.