Trial reportScientific reports2019
Association between HOMA-IR and Frailty among U.S. Middle-aged and Elderly Population.
Trial report in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 44 citations in OpenAlex.
- Effect of a Low-Moderate Exercise Program on Dysmetabolism in Older Adults: Results of a Randomized Controlled Trial.Nutrients · 2022Trial
- Associations of long-term average and variability of estimated glucose disposal rate with frailty progression: evidence from two prospective cohorts.Journal of translational medicine · 2026Article
- Estimated glucose disposal rate and frailty in middle and older aged adults from three prospective cohorts.Scientific reports · 2025Article
- Association of Insulin Resistance with Dysglycemia in Elder Koreans: Age- and Sex-Specific Cutoff Values.Journal of personalized medicine · 2025Article
- The Effect of Frailty on Body Composition and Its Impact on the Use of SGLT-2 Inhibitors and GLP-1RA in Older Persons with Diabetes.Metabolites · 2025Review
- Differential proteomic profiles between cognitive frail and robust older adults from the MELoR cohort.GeroScience · 2025Article
- Association between non-insulin-based insulin resistance indicators and frailty progression: a national cohort study and mendelian randomization analysis.Cardiovascular diabetology · 2025Article
- Cumulative estimated glucose disposal rate predicts frailty progression in Chinese adults with diabetes: a 9-year follow-up cohort study.Frontiers in medicine · 2025Article
- Estimated glucose disposal rate predicts frailty through diabetes: Evidence from machine learning and mediation models in NHANES.PloS one · 2025Article
- The Role of Frailty and Myosteatosis in Predicting All-Cause Mortality in Older Adults with Cancer.Current oncology (Toronto, Ont.) · 2024Article
- Gender-specific capacity of insulin resistance proxies to predict functional decline in older adults.The journal of nutrition, health & aging · 2024Article
- High cotinine levels as an associated factor with frailty status in older adults: evidence from the NHANES study.BMC geriatrics · 2024Article
- Association of metabolic syndrome severity with frailty progression among Chinese middle and old-aged adults: a longitudinal study.Cardiovascular diabetology · 2024Article
- Relationship between changes in the triglyceride glucose-body mass index and frail development trajectory and incidence in middle-aged and elderly individuals: a national cohort study.Cardiovascular diabetology · 2024Article
- Long-term insulin resistance is associated with frailty, frailty progression, and cardiovascular disease.Journal of cachexia, sarcopenia and muscle · 2024Article
- Association of the triglyceride-glucose index and its related parameters with frailty.Lipids in health and disease · 2024Article
- The intersection of frailty and metabolism.Cell metabolism · 2024Review
- Association of triglyceride-glucose index trajectory and frailty in urban older residents: evidence from the 10-year follow-up in a cohort study.Cardiovascular diabetology · 2023Article
- Multisystem physiological perspective of human frailty and its modulation by physical activity.Physiological reviews · 2023Review
- Community Efficacy for Non-Communicable Disease Management and Medication Adherence: The Sequential Mediating Role of Self-Efficacy and Depressive Symptoms.Patient preference and adherence · 2023Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous literatures revealed that homeostasis model assessment-estimated insulin resistance (HOMA-IR) was one of the cardio-metabolic risk factors. This study was conducted to access the association between HOMA-IR and frailty in the United States of America (U.S.) middle-aged and elderly high-risk insulin-resistant population. In the National Health and Nutrition Examination Survey (NHANES III) from 1988 to 1994, the study included 3,893 participants. In order to exam the association between HOMA-IR and frailty in the middle-aged and elderly population through the regression model adjusted for multiple covariates, we divided the participants into middle aged group (Age <65 years) and elderly group (Age > = 65 years) in this study. Each group was then divided into tertiles depending on their HOMA-IR levels. Higher level of HOMA-IR was significantly associated with frailty in the elderly group, but this association was not seen in the middle-aged population. These results demonstrated that the HOMA-IR level can be a novel risk assessment of frailty in elderly high-risk insulin-resistant individuals (Age > = 65 years).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.