ArticleComputational and mathematical methods in medicine2019
Modeling the Effect of High Calorie Diet on the Interplay between Adipose Tissue, Inflammation, and Diabetes.
Article in Computational and mathematical methods in medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06195566 (Physics Informed Machine Learning-based Prediction and Reversion of Impaired Fasting Glucose Management), which is not on this map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Physics Informed Machine Learning-based Prediction and Reversion of Impaired Fasting Glucose Management
Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- Data, Process, and Data-Driven Representations of Digital Twins in Diabetes: Scoping Review.JMIR diabetes · 2026Review
- Caspase-1/11 deficiency and cold exposure enhance the anti-tumor activity of brown adipose tissue secretome against breast cancer cells.Cancer & metabolism · 2026Article
- Toward mechanistic medical digital twins: some use cases in immunology.Frontiers in digital health · 2024Review
- Influence of Sociodemographic Variables and Healthy Habits on the Values of Insulin Resistance Indicators in 386,924 Spanish Workers.Nutrients · 2023Observational
- A multi-scale digital twin for adiposity-driven insulin resistance in humans: diet and drug effects.Diabetology & metabolic syndrome · 2023Article
- The Mechanism of Kelulut Honey in Reversing Metabolic Changes in Rats Fed with High-Carbohydrate High-Fat Diet.Molecules (Basel, Switzerland) · 2023Article
- African American Females Are Less Metabolically Flexible Compared with Caucasian American Females following a Single High-Fat Meal: A Pilot Study.International journal of environmental research and public health · 2022Article
- From Infection to Immunity: Understanding the Response to SARS-CoV2 ThroughFrontiers in immunology · 2021Article
- Periodontal Inflammation and Systemic Diseases: An Overview.Frontiers in physiology · 2021Review
- Potential predictors of type-2 diabetes risk: machine learning, synthetic data and wearable health devices.BMC bioinformatics · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundType 2 diabetes (T2D) is a chronic metabolic disease potentially leading to serious widespread tissue damage. Human organism develops T2D when the glucose-insulin control is broken for reasons that are not fully understood but have been demonstrated to be linked to the emergence of a chronic inflammation. Indeed such low-level chronic inflammation affects the pancreatic production of insulin and triggers the development of insulin resistance, eventually leading to an impaired control of the blood glucose concentration. On the contrary, it is well-known that obesity and inflammation are strongly correlated.
aimIn this study, we investigate
resultsThe model reproduces the fat accumulation due to excessive caloric intake observed in two clinical studies. Moreover, while showing consistent weight gains over long periods of time, it reveals a drift of the macrophage population toward the proinflammatory phenotype, thus confirming its association with fatness.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.