ArticleJournal of biomedical optics2019
Optical coherence elastography of cold cataract in porcine lens.
Article in Journal of biomedical optics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
- Phantoms for use in optical coherence elastography.Journal of biomedical optics · 2026Review
- Quantitative fs-laser crystalline lens softening surgery towards presbyopia treatment based on optical coherence elastography.Biomedical optics express · 2025Article
- Low-cost optical system for laser phacoemulsification of cataracts.Biophotonics discovery · 2025Article
- Acoustic Radiation Force Optical Coherence Elastography of the Crystalline Lens: Safety.Translational vision science & technology · 2024Article
- Functional effects of the spatial-varying lens mechanical properties in accommodation.JPhys photonics · 2024Article
- High-Frequency Optical Coherence Elastography for Gingival Tissue Characterization: Variability in Stiffness and Response to Physiological Conditions.Biomaterials research · 2024Article
- Phase-Decorrelation Optical Coherence Tomography Measurement of Cold-Induced Nuclear Cataract.Translational vision science & technology · 2023Article
- The lens capsule significantly affects the viscoelastic properties of the lens as quantified by optical coherence elastography.Frontiers in bioengineering and biotechnology · 2023Article
- Article
- Pseudoexfoliation and Cataract Syndrome Associated with Genetic and Epidemiological Factors in a Mayan Cohort of Guatemala.International journal of environmental research and public health · 2021Article
- Multimodal quantitative optical elastography of the crystalline lens with optical coherence elastography and Brillouin microscopy.Biomedical optics express · 2020Article
- Ultrahigh-sensitive optical coherence elastography.Light, science & applications · 2020Article
- Advances in Doppler optical coherence tomography and angiography.Translational biophotonics · 2019Article
- Simultaneously imaging and quantifyingAPL photonics · 2019Article
- Biomechanical contributions to cataract development and implications for treatment strategies.Advances in ophthalmology practice and researchReview
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Cataract is one of the most prevalent causes of blindness around the world. Understanding the mechanisms of cataract development and progression is important for clinical diagnosis and treatment. Cold cataract has proven to be a robust model for cataract formation that can be easily controlled in the laboratory. There is evidence that the biomechanical properties of the lens can be significantly changed by cataract. Therefore, early detection of cataract, as well as evaluation of therapies, could be guided by characterization of lenticular biomechanical properties. In this work, we utilized optical coherence elastography (OCE) to monitor the changes in biomechanical properties of ex vivo porcine lenses during formation of cold cataract. Elastic waves were induced in the porcine lenses by a focused micro air-pulse while the lenses were cooled, and the elastic wave velocity was translated to Young's modulus of the lens. The results show an increase in the stiffness of the lens due to formation of the cold cataract (from 11.3 ± 3.4 to 21.8 ± 7.8 kPa). These results show a relation between lens opacity and stiffness and demonstrate that OCE can assess lenticular biomechanical properties and may be useful for detecting and potentially characterizing cataracts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.