ArticleeLife2019
Impaired ABCA1/ABCG1-mediated lipid efflux in the mouse retinal pigment epithelium (RPE) leads to retinal degeneration.
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Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
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68citing papers in PubMed
11.0field-weighted citation impact, top 1% of its field
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Who cites it
68 citing papers in PubMed, 98 citations in OpenAlex.
- Enhanced chromatin compaction is associated with de novo expression of a nuclear microprotein, global loss of H3 acetylation and local transcriptional changes in retinal rod photoreceptors.Research square · 2026Article
- Interactions Between Epidermal Growth Factor-Containing Fibulin-Like Extracellular Matrix Protein 1 and Tissue Inhibitor of Metalloproteinases-3 and Relevance to Age-Related Macular Degeneration.Ophthalmology science · 2026Review
- Polyunsaturated fatty acid metabolism in the retinal pigment epithelium and its association with outer retinal disease.Mammalian genome : official journal of the International Mammalian Genome Society · 2026Review
- Lipid homeostasis plays a critical role in inherited and acquired retinal diseases.Communications biology · 2026Review
- A novel multiplex RNAi therapy simultaneously targets Hif1a and Hif2a to defy retinal degeneration in two models of AMD.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Article
- Understanding the link between lipid and ocular disorders for effective therapy.Archives of medical science : AMS · 2026Article
- Retinal Carotenoid Supplementation Increases HDL Cholesterol in Humans and Mice.Life (Basel, Switzerland) · 2025Article
- The intersection of mitochondria, lipids, and ferroptosis: a new avenue for dry age-related macular degeneration.Apoptosis : an international journal on programmed cell death · 2025Review
- RPGRORF15 Mutations Disrupt Lysosomal Lipid Metabolism in Retinal Pigment Epithelium Cells and Cause Retinitis Pigmentosa.Investigative ophthalmology & visual science · 2025Article
- Tetrahedral DNA Framework Penetrating Ocular Barrier for Treatment of Retinal Oxidative Stress.ACS omega · 2025Article
- Traditional Chinese Medicine, Ziyin-Mingmu Decoction, Regulates Cholesterol Metabolism, Oxidative Stress, Inflammation and Gut Microbiota in Age-related Macular Degeneration Models.Pharmaceutical research · 2025Article
- Apolipoprotein M attenuates age-related macular degeneration phenotypes via sphingosine-1-phosphate signaling and lysosomal lipid catabolism.Nature communications · 2025Article
- Gene therapy for age-related macular degeneration: a promising frontier in vision preservation.Cell communication and signaling : CCS · 2025Review
- Alzheimer's disease and age-related macular degeneration: Shared and distinct immune mechanisms.Immunity · 2025Review
- Dietary effects on the retina of hamsters.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Modified Zhujing pill regulates RPE cholesterol metabolism and gut microbiota in an age-related macular degeneration mouse model.Frontiers in cellular and infection microbiology · 2025Article
- Eye on the horizon: The metabolic landscape of the RPE in aging and disease.Progress in retinal and eye research · 2025Review
- Aberrant lipid accumulation and retinal pigment epithelium dysfunction in PRCD-deficient mice.Experimental eye research · 2024Article
- Cholesterol Accumulation Promotes Photoreceptor Senescence and Retinal Degeneration.Investigative ophthalmology & visual science · 2024Article
- Cholesterol-dependent LXR transcription factor activity represses pronociceptive effects of estrogen in sensory neurons and pain induced by myelin basic protein fragments.Brain, behavior, & immunity - health · 2024Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
22 authors at 6 institutions in 5 countries.
Federica StortiLab for Retinal Cell Biology, Department of Ophthalmology, University of Zurich, Schlieren, Switzerland.ORCID 0000-0002-5764-1656
Katrin KleeLab for Retinal Cell Biology, Department of Ophthalmology, University of Zurich, Schlieren, Switzerland.
Vyara TodorovaLab for Retinal Cell Biology, Department of Ophthalmology, University of Zurich, Schlieren, Switzerland.
Regula SteinerInstitute of Clinical Chemistry, University of Zurich, Schlieren, Switzerland.
Alaa OthmanInstitute of Clinical Chemistry, University of Zurich, Schlieren, Switzerland.
Saskia van der Velde-VisserDepartment of Human Genetics, Radboud University Medical Center, Nijmegen, Netherlands.
Marijana SamardzijaLab for Retinal Cell Biology, Department of Ophthalmology, University of Zurich, Schlieren, Switzerland.
Isabelle MeneauDepartment of Ophthalmology, University Hospital Zurich, Zurich, Switzerland.
Maya BarbenLab for Retinal Cell Biology, Department of Ophthalmology, University of Zurich, Schlieren, Switzerland.
Duygu KarademirLab for Retinal Cell Biology, Department of Ophthalmology, University of Zurich, Schlieren, Switzerland.
Valda PauzuolyteLab for Retinal Cell Biology, Department of Ophthalmology, University of Zurich, Schlieren, Switzerland.
Sanford L BoyeDepartment of Ophthalmology, University of Florida, Gainesville, United States.ORCID 0000-0002-8803-9369
Frank BlaserDepartment of Ophthalmology, University Hospital Zurich, Zurich, Switzerland.
Christoph UllmerRoche Pharma Research and Early Development, Roche Innovation Center Basel, F Hoffmann-La Roche Ltd., Basel, Switzerland.
Joshua L DunaiefDepartment of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, United States.
Thorsten HornemannInstitute of Clinical Chemistry, University of Zurich, Schlieren, Switzerland.
Lucia RohrerInstitute of Clinical Chemistry, University of Zurich, Schlieren, Switzerland.
Anneke den HollanderDepartment of Human Genetics, Radboud University Medical Center, Nijmegen, Netherlands.
Arnold von EckardsteinInstitute of Clinical Chemistry, University of Zurich, Schlieren, Switzerland.
Jürgen FingerleNatural and Medical Sciences Institute, University of Tübingen, Tübingen, Germany.
Cyrille MaugeaisRoche Pharma Research and Early Development, Roche Innovation Center Basel, F Hoffmann-La Roche Ltd., Basel, Switzerland.
Christian GrimmLab for Retinal Cell Biology, Department of Ophthalmology, University of Zurich, Schlieren, Switzerland.ORCID 0000-0001-9318-4352
University of Zurich · CHRadboud University Nijmegen · NLRoche (Switzerland) · CHUniversity Hospital of Zurich · CHPenn Presbyterian Medical Center · USUniversity of Florida · US
Funding
Scientific TransparencyP30EY001583 · NEI · UNIVERSITY OF PENNSYLVANIA · PI CLAIRE H MITCHELL · 1985 to 2026
$19.5MNEI NIH HHS P30 EY001583Roche RPF 378Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 31003A_173008
Abstract
Age-related macular degeneration (AMD) is a progressive disease of the retinal pigment epithelium (RPE) and the retina leading to loss of central vision. Polymorphisms in genes involved in lipid metabolism, including the ATP-binding cassette transporter A1 (
Indexed as
Lipid MetabolismAnimalsATP Binding Cassette Transporter 1ATP Binding Cassette Transporter, Subfamily G, Member 1Cell LineDisease Models, AnimalHumansInflammationMicePhotoreceptor CellsRetinal DegenerationRetinal Pigment EpitheliumABCA1 protein, humanAbca1 protein, mouseABCG1 protein, humanABCG1 protein, mouseATP Binding Cassette Transporter 1ATP Binding Cassette Transporter, Subfamily G, Member 1ABCA1ABCG1age-related macular degenerationhumanhuman biologylipid effluxmedicinemouseneuroscienceretinal degenerationretinal pigment epithelium
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.