ArticleEuropean journal of preventive cardiology2019
Age differences in contemporary treatment of patients with chronic heart failure and reduced ejection fraction.
Article in European journal of preventive cardiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Efficacy and Safety of Heart Failure Treatment According to Frailty Status: A Systematic Review.Journal of the American Heart Association · 2025Pooled it
- Age-stratified effects of intravenous ferric derisomaltose in heart failure with iron deficiency: insights from the IRONMAN trial.Heart (British Cardiac Society) · 2025Trial
- Efficacy and Safety of Dapagliflozin According to Frailty in Patients With Heart Failure: A Prespecified Analysis of the DELIVER Trial.Circulation · 2022Trial
- Guideline-directed medical therapy in older adults with heart failure; Are there differences across age group?BMC geriatrics · 2026Article
- Real-World Association of SGLT2 Inhibitors with Mortality in Very Elderly Patients with HFrEF and CKD.Biomedicines · 2026Article
- International Utah Cardiac Recovery Symposium (U-CARS) 2025: Clinical Science Proceedings.Heart failure reviews · 2026Article
- Program theory and economic insights of a comprehensive geriatric assessment for frail heart failure patients.BMC geriatrics · 2025Article
- Article
- Impact of socio-demographic and ethnic determinants in guideline-directed medical therapy implementation during heart failure hospitalization.European heart journal open · 2025Article
- Evaluation of prescribing adherence to guideline-directed medical therapy in patients with chronic heart failure: a retrospective study at the National Heart Centre in Oman.BMC cardiovascular disorders · 2025Article
- Article
- Deprescribing strategies in older patients with heart failure.Internal and emergency medicine · 2025Review
- Review
- An Observational Study of Evidence-Based Therapies in Older Patients with Heart Failure with Reduced Ejection Fraction: Insights from a Dedicated Heart Failure Clinic.Journal of clinical medicine · 2024Article
- Age-Related Outcomes in Heart Failure with Mildly Reduced Ejection Fraction.Journal of clinical medicine · 2024Article
- Prevalence of heart failure and trends in its pharmacological treatment between 2000 and 2017 among very old people.BMC geriatrics · 2024Article
- Guideline implementation, drug sequencing, and quality of care in heart failure: design and rationale of TITRATE-HF.ESC heart failure · 2024Article
- Outcomes following cardiac resynchronisation therapy in older people.Age and ageing · 2023Article
- The median doses of beta-blockers among older adults with heart failure with reduced ejection fraction.Journal of the American Geriatrics Society · 2023Article
- Long-Term Outcomes of Early Coronary Artery Disease Testing After New-Onset Heart Failure.Circulation. Heart failure · 2023Article
Corrections and comments
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Authors and funding
11 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundElderly patients are underrepresented in clinical trials but comprise the majority of heart failure patients. Data on age-specific use of heart failure therapy are limited. The European Society of Cardiology heart failure guidelines provide no age-specific treatment recommendations. We investigated practice-based heart failure management in a large registry at heart failure outpatient clinics. DESIGN AND
methodsWe studied 8351 heart failure with reduced ejection fraction patients at 34 Dutch outpatient clinics between 2013 and 2016. The mean age was 72.3 ± 11.8 years and we divided age into three categories: less than 60 years (13.9%); 60-74 years (36.0%); and 75 years and over (50.2%).
resultsElderly heart failure with reduced ejection fraction patients (≥75 years) received significantly fewer beta-blockers (77.8% vs. 84.2%), renin-angiotensin system inhibitors (75.2% vs. 89.7%), mineralocorticoid receptor antagonists (50.6% vs. 59.6%) and ivabradine (2.9% vs. 9.3%), but significantly more diuretics (88.1% vs. 72.6%) compared to patients aged less than 60 years (
conclusionWith increasing age, heart failure with reduced ejection fraction patients less often received guideline-recommended medication prescriptions and also in a lower dosage. In addition, a lower percentage of implantable cardioverter defibrillator and cardiac resynchronisation therapy device implantation in elderly patients was observed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.