Evidence map›Paper›PMID 30872093›Full record

ReviewBrain, behavior, and immunity2019

Neuroimmunology of the female brain across the lifespan: Plasticity to psychopathology.

R M Barrientos, P J Brunton, K M Lenz, L Pyter, S J Spencer

Open access · greenAbstract readReview
In one paragraph

Review in Brain, behavior, and immunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 4 countries.

R M BarrientosInstitute for Behavioral Medicine Research, Wexner Medical Centre, The Ohio State University, Columbus, OH 43210, United States; Department of Psychiatry and Behavioral Health, Wexner Medical Centre, The Ohio State University, Columbus, OH 43210, United States; Chronic Brain Injury Program, Discovery Themes Initiative, The Ohio State University, Columbus, OH 43210, United States.
P J BruntonCentre for Discovery Brain Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, Scotland, UK; Zhejiang University-University of Edinburgh Joint Institute, Zhejiang University School of Medicine, International Campus, Haining, Zhejiang 314400, PR China.
K M LenzInstitute for Behavioral Medicine Research, Wexner Medical Centre, The Ohio State University, Columbus, OH 43210, United States; Department of Psychology, Department of Neuroscience, The Ohio State University, Columbus, OH 43210, United States.
L PyterInstitute for Behavioral Medicine Research, Wexner Medical Centre, The Ohio State University, Columbus, OH 43210, United States; Department of Psychiatry and Behavioral Health, Wexner Medical Centre, The Ohio State University, Columbus, OH 43210, United States.
S J SpencerSchool of Health and Biomedical Sciences, RMIT University, Melbourne, Vic. 3083, Australia. Electronic address: Sarah.Spencer@rmit.edu.au.
Institute for Behavioral Medicine · USRMIT University · AUThe Ohio State University · USUniversity of Edinburgh · GB

Funding

Neuroinflammation, Inflammatory Challenge, and MemoryR01AG028271 · NIA · UNIVERSITY OF COLORADO · PI MAIER, STEVEN F · 2006 to 2016
$3.8M
Neuroinflammation, Inflammatory Challenge, and MemoryRF1AG028271 · NIA · UNIVERSITY OF COLORADO · PI BARRIENTOS, RUTH M, MAIER, STEVEN F · 2018 to 2021
$2.4M
(PQ #10) Gut-brain interactions underlying chemotherapy-induced behavioral comorbiditiesR01CA216290 · NCI · OHIO STATE UNIVERSITY · PI PYTER, LEAH M · 2017 to 2021
$2.1M
The impact of aging on cancer-related cognitive comorbidities and mechanismsR21AG058109 · NIA · OHIO STATE UNIVERSITY · PI BARRIENTOS, RUTH M, PYTER, LEAH M · 2018 to 2019
$440k
Developmental programming of sex differences in brain innate immune cellsR21MH105826 · NIMH · OHIO STATE UNIVERSITY · PI LENZ, KATHRYN M. · 2015 to 2016
$407k
Biotechnology and Biological Sciences Research CouncilNCI NIH HHS R01 CA216290NIA NIH HHS R01 AG028271NIA NIH HHS R21 AG058109NIA NIH HHS RF1 AG028271NIMH NIH HHS R21 MH105826
6 · The paper itself

Abstract

The female brain is highly dynamic and can fundamentally remodel throughout the normal ovarian cycle as well as in critical life stages including perinatal development, pregnancy and old-age. As such, females are particularly vulnerable to infections, psychological disorders, certain cancers, and cognitive impairments. We will present the latest evidence on the female brain; how it develops through the neonatal period; how it changes through the ovarian cycle in normal individuals; how it adapts to pregnancy and postpartum; how it responds to illness and disease, particularly cancer; and, finally, how it is shaped by old age. Throughout, we will highlight female vulnerability to and resilience against disease and dysfunction in the face of environmental challenges.

Indexed as

Age FactorsBrainFemaleHumansLongevityNeuroimmunomodulationNeuronal PlasticityPregnancyPregnant PeoplePsychoneuroimmunologyPsychopathologyResilience, Psychological

Identifiers

PMID30872093
PMCPMC6591071
OpenAlexW2921557770

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.