Evidence map›Paper›PMID 30873934›Full record

ReviewMicrobiology spectrum2019

Allister J Loughran, Carlos J Orihuela, Elaine I Tuomanen

Abstract readReview
In one paragraph

Review in Microbiology spectrum, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
108citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

108 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. A MultinuclearACS omega · 2026
    Article
  6. Lactate Oxidase (LctO) Acts as a Metabolic Checkpoint RestrainingbioRxiv : the preprint server for biology · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Identification ofJournal of proteome research · 2025
    Article
  18. Article
  19. Angiotensin-(1-7) treatment improves pneumonia and prevents sepsis caused by pneumococcal infection.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
    Article
  20. Article

48 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Allister J LoughranDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105.
Carlos J OrihuelaDepartment of Microbiology, The University of Alabama at Birmingham School of Medicine, Birmingham, AL 35294.
Elaine I TuomanenDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105.

Funding

Bioactivities of pneumococcal cell wall in neuropathogenesisR01AI128756 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Elaine I Tuomanen · 2017 to 2026
$4.5M
NIAID NIH HHS R01 AI128756
6 · The paper itself

Abstract

Streptococcus pneumoniae (the pneumoccus) is the leading cause of otitis media, community-acquired pneumonia, and bacterial meningitis. The success of the pneumococcus stems from its ability to persist in the population as a commensal and avoid killing by immune system. This chapter first reviews the molecular mechanisms that allow the pneumococcus to colonize and spread from one anatomical site to the next. Then, it discusses the mechanisms of inflammation and cytotoxicity during emerging and classical pneumococcal infections.

Indexed as

BloodBrainCell WallCommunity-Acquired InfectionsEar, MiddleEpithelial CellsFetusHeartHumansInflammationMeningitis, BacterialNasopharynxOtitis MediaPneumococcal InfectionsPneumoniaRespiratory System

Identifiers

PMID30873934
PMCPMC6422050

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.