Evidence map›Paper›PMID 30874342›Full record

ReviewImmunological reviews2019

Germinal center B cell initiation, GC maturation, and the coevolution of its stromal cell niches.

Ann M Haberman, David G Gonzalez, Patrick Wong, Ting-Ting Zhang, Steven M Kerfoot

Abstract readReview
In one paragraph

Review in Immunological reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. IgMScientific reports · 2025
    Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. GABA signaling enforces intestinal germinal center B cell differentiation.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Plasma cells, plasmablasts, and AIDHistochemistry and cell biology · 2020
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ann M HabermanDepartment of Immunobiology, Yale University, New Haven, Connecticut.ORCID 0000-0001-5168-8229
David G GonzalezDepartment of Immunobiology, Yale University, New Haven, Connecticut.
Patrick WongDepartment of Immunobiology, Yale University, New Haven, Connecticut.
Ting-Ting ZhangDepartment of Immunobiology, Yale University, New Haven, Connecticut.
Steven M KerfootDepartment of Microbiology and Immunology, Western University, London, ON, Canada.

Funding

Yale Rheumatic Diseases Research Core CenterP30AR053495 · NIAMS · YALE UNIVERSITY · PI HABERMAN, ANN M · 2007 to 2017
$7.0M
In vivo imaging of T and B cell interactions in germinal center initiationR01AI080850 · NIAID · YALE UNIVERSITY · PI HABERMAN, ANN M · 2009 to 2012
$1.6M
Analysis of B cell transcriptome shifts prior to lineage divergence in vivoR21AI101704 · NIAID · YALE UNIVERSITY · PI HABERMAN, ANN M · 2012 to 2013
$440k
Definition of follicular stromal cell subset interactions with B cellsR03AI105734 · NIAID · YALE UNIVERSITY · PI HABERMAN, ANN M · 2013 to 2014
$166k
NIAID NIH HHS R01 AI080850NIAID NIH HHS R03 AI105734NIAID NIH HHS R21 AI101704NIAMS NIH HHS P30 AR053495NIAMS NIH HHS P30AR053495
6 · The paper itself

Abstract

Throughout the developing GC response, B cell survival and fate choices made at the single cell level are dependent on signals received largely through interactions with other cells, often with cognate T cells. The type of signals that a given B cell can encounter is dictated by its location within tissue microarchitecture. The focus of this review is on the initiation and evolution of the GC response at the earliest time points. Here, we review the key factors influencing the progression of GC B cell differentiation that are both stage and context dependent. Finally, we describe the coevolution of niches within and surrounding the GC that influence the outcome of the GC response.

Indexed as

AnimalsB-LymphocytesCell DifferentiationGerminal CenterHumansLymphocyte ActivationParacrine CommunicationSignal TransductionStromal CellsT-LymphocytesB cellscell differentiationcytokineslineage commitment/specificationstromal cellstranscription factors

Identifiers

PMID30874342
PMCPMC10234181

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.