Evidence map›Paper›PMID 30879219›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2019

ERCC6L2 rs591486 polymorphism and risk for amyotrophic lateral sclerosis in Greek population.

Efthimios Dardiotis, Emmanouil Karampinis, Vasileios Siokas, Athina-Maria Aloizou, Dimitrios Rikos, Styliani Ralli, Dimitra Papadimitriou, Dimitrios P Bogdanos, Georgios M Hadjigeorgiou

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Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Medicina (Kaunas, Lithuania) · 2021
    Article
  4. Article
  5. CYP1A2 rs762551 polymorphism and risk for amyotrophic lateral sclerosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021
    Article
  6. Rare Neurologic Diseases and Neurological Sciences: a report for the celebration of the 2020 Rare Diseases Day.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020
    Article
  7. Does SCFD1 rs10139154 Polymorphism Decrease Alzheimer's Disease Risk?Journal of molecular neuroscience : MN · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Efthimios DardiotisDepartment of Neurology, University Hospital of Larissa, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Biopolis, Mezourlo Hill, 41100, Larissa, Greece. edar@med.uth.gr.ORCID http://orcid.org/0000-0003-2957-641X
Emmanouil KarampinisDepartment of Neurology, University Hospital of Larissa, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Biopolis, Mezourlo Hill, 41100, Larissa, Greece.
Vasileios SiokasDepartment of Neurology, University Hospital of Larissa, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Biopolis, Mezourlo Hill, 41100, Larissa, Greece.
Athina-Maria AloizouDepartment of Neurology, University Hospital of Larissa, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Biopolis, Mezourlo Hill, 41100, Larissa, Greece.
Dimitrios RikosDepartment of Neurology, University Hospital of Larissa, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Biopolis, Mezourlo Hill, 41100, Larissa, Greece.
Styliani RalliDepartment of Neurology, University Hospital of Larissa, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Biopolis, Mezourlo Hill, 41100, Larissa, Greece.
Dimitra PapadimitriouNeurological Department, Henry Dunant Hospital Center, 107 Mesogeion Avenue, 11526, Athens, Greece.
Dimitrios P BogdanosDepartment of Rheumatology and Clinical Immunology, University General Hospital of Larissa, Faculty of Medicine, School of Health Sciences, University of Thessaly, Viopolis, 40500, Larissa, Greece.
Georgios M HadjigeorgiouDepartment of Neurology, Medical School, University of Cyprus, Nicosia, Cyprus.
University of Thessaly · GRHenry Dunant Hospital · GRUniversity of Cyprus · CY

Funding

The study was supported in part by a research grant of the Research Committee of the University of Thessaly, Greece (Code: 5287). 5287
6 · The paper itself

Abstract

backgroundΑ number of genetic variants have been associated with amyotrophic lateral sclerosis (ALS). A recent study supports that rs591486 across the ERCC6L2 gene and exposure to pesticides seem to have a joint effect on the development of Parkinson's disease, a disease which shares a few common characteristics with ALS.

objectiveTo detect a possible contribution of rs591486 ERCC6L2 to ALS.

methodsA total of 155 patients with ALS and 155 healthy controls were included in the study and genotyped for rs591486. Using logistic regression analyses (crude and adjusted for age and sex), rs591486 was tested for association with ALS risk. Subgroup analysis based on ALS site of onset was also performed. Cox regression analysis was applied in order for the effect of ERCC6L2 rs591486 on ALS age of onset to be tested.

resultsAdjusted analysis showed that ERCC6L2 rs591486 was associated with an increased risk of ALS development, in dominant [odds ratio, OR (95% confidence interval, CI) 2.15 (1.04-4.46), p = 0.037] and over-dominant [OR (95%CI) = 1.91 (1.01-3.60), p = 0.043], modes. Subgroup analysis based on ALS site of onset revealed an association between ERCC6L2 rs591486 and ALS with limb onset. Results for Cox regression analysis indicated that G/A carriers had a lower age of ALS limb onset when compared to G/G carriers.

conclusionsThe current study provides preliminary indication for an implication of ERCC6L2 rs591486 in ALS development, as a possible genetic risk factor. These results possibly suggest that oxidative stress may be the main contributor in the pathophysiology of ALS.

Indexed as

Genetic Predisposition to DiseaseAgedAmyotrophic Lateral SclerosisDNA HelicasesFemaleGenetic Association StudiesGenotypeGreeceHumansMaleMiddle AgedPolymorphism, Single NucleotideWhite PeopleDNA HelicasesERCC6L2 protein, humanALSERCC6L2Oxidative stressPesticidesPolymorphism

Identifiers

PMID30879219
OpenAlexW2921591070

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.