Evidence map›Paper›PMID 30890857›Full record

ArticleJournal of orthopaedics

Association of eNOS 27-bp VNTR, 894G>T and 786T>C polymorphisms with susceptibility to Legg-Calve-Perthes Disease in Iranian children.

Mohammad Reza Azarpira, Mohammad Mahdi Ghilian, Mohammad Reza Sobhan, Masoud Mahdinezhad-Yazdi, Kazem Aghili, Hossein Ahrar, Hossein Neamatzadeh

Open access · bronzeAbstract read
In one paragraph

Article in Journal of orthopaedics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Association ofGenes · 2025
    Article
  4. Article
  5. Molecular Biomarkers in Perthes Disease: A Review.Diagnostics (Basel, Switzerland) · 2023
    Review
  6. Legg-Calvé-Perthes disease overview.Orphanet journal of rare diseases · 2022
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Mohammad Reza AzarpiraBone and Joint Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Mohammad Mahdi GhilianBone and Joint Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Mohammad Reza SobhanDepartment of Orthopedics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Masoud Mahdinezhad-YazdiDepartment of Orthopedics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Kazem AghiliDepartment of Radiology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Hossein AhrarDepartment of Radiology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Hossein NeamatzadehDepartment of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Shahid Sadoughi University of Medical Sciences and Health Services · IRShiraz University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim of this study was to analyze the association of eNOS polymorphisms with risk of Legg-Calve-Perthes Disease (LCPD).

methodsThe study comprised of 45 LCPD patients and 55 controls. The eNOS polymorphisms were genotyped with PCR and by PCR-RFLP.

resultsThe eNOS 894G > T and -786T > C polymorphisms were significantly associated with an increased risk of LCPD. However, there was no significant association between eNOS 27-bp VNTR polymorphism and LCPD risk.

conclusionOur results suggest that the eNOS 894G > T and -786T > C polymorphisms may be a risk factor for LCPD in Iranian children, but not 27-bp VNTR polymorphism.

Indexed as

Legg-Calve-Perthes diseaseNitric oxide synthasePolymorphism

Identifiers

PMID30890857
PMCPMC6403418
OpenAlexW2915776198

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.