Evidence map›Paper›PMID 30892934›Full record

ArticleAmerican journal of physiology. Renal physiology2019

Expansion of regulatory T cells using low-dose interleukin-2 attenuates hypertension in an experimental model of systemic lupus erythematosus.

Erin B Taylor, Jennifer M Sasser, Kenji J Maeda, Michael J Ryan

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Revisiting sex as a biological variable in hypertension research.The Journal of clinical investigation · 2024
    Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Blood pressure and albuminuria in a female mouse model of systemic lupus erythematosus: impact of long-term high salt consumption.American journal of physiology. Regulatory, integrative and comparative physiology · 2020
    Article
  12. 1,3-Butanediol attenuates hypertension and suppresses kidney injury in female rats.American journal of physiology. Renal physiology · 2020
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Erin B TaylorDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi.
Jennifer M SasserDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi.ORCID 0000-0001-7161-5502
Kenji J MaedaDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.
Michael J RyanDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi.ORCID 0000-0002-5679-6031
Jackson Memorial Hospital · USUniversity of Mississippi Medical Center · US

Funding

Tracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI HALL, JOHN E · 2016 to 2025
$38.2M
Hypertension and Cardiorenal Research Training ProgramT32HL105324 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI Joey P. Granger · 2010 to 2026
$7.8M
Mechanisms of Cardiorenal Disease following PreeclampsiaR01HL134711 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI GARRETT, MICHAEL R · 2017 to 2021
$1.9M
Mechanisms of Renoprotection by Relaxin in HypertensionK01DK095018 · NIDDK · UNIVERSITY OF MISSISSIPPI MED CTR · PI SASSER, JENNIFER M · 2012 to 2016
$634k
BLRD VA I01 BX002604NHLBI NIH HHS R01 HL134711NHLBI NIH HHS T32 HL105324NIDDK NIH HHS K01 DK095018NIGMS NIH HHS U54 GM115428
6 · The paper itself

Abstract

Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune disorder that is characterized by prevalent hypertension, renal injury, and cardiovascular disease. Numerous studies have reported a low prevalence and/or impaired function of regulatory T (T

Indexed as

AnimalsFemaleHypertensionInterleukin-2Lupus Erythematosus, SystemicMiceRecombinant ProteinsT-Lymphocytes, RegulatoryInterleukin-2Recombinant Proteinsautoimmunityhypertensioninterleukin-2regulatory T cellssystemic lupus erythematosus

Identifiers

PMID30892934
PMCPMC6879936
OpenAlexW2924094171

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.