Evidence map›Paper›PMID 30894635›Full record

ArticleScientific reports2019

Dietary Sargassum fusiforme improves memory and reduces amyloid plaque load in an Alzheimer's disease mouse model.

Jeroen Bogie, Cindy Hoeks, Melissa Schepers, Assia Tiane, Ann Cuypers, Frank Leijten, Yupyn Chintapakorn, Thiti Suttiyut, Surachai Pornpakakul, Dicky Struik and 14 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 1 pooled it
10.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 1 synthesis or guideline pooled it, 85 citations in OpenAlex.

  1. Pooled it
  2. The Effect ofNutrients · 2024
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  6. Review
  7. Review
  8. Modulatory effects ofNutrition research and practice · 2026
    Article
  9. Review
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  11. Article
  12. Review
  13. Therapeutic Potential ofLife (Basel, Switzerland) · 2025
    Review
  14. Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. LXR agonism for CNS diseases: promises and challenges.Journal of neuroinflammation · 2024
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 9 institutions in 6 countries.

Jeroen BogieDepartment of Immunology and Biochemistry, Biomedical research institute, Hasselt University, Martelarenlaan 42, 3500, Hasselt, Belgium.
Cindy HoeksDepartment of Immunology and Biochemistry, Biomedical research institute, Hasselt University, Martelarenlaan 42, 3500, Hasselt, Belgium.
Melissa SchepersDepartment of Immunology and Biochemistry, Biomedical research institute, Hasselt University, Martelarenlaan 42, 3500, Hasselt, Belgium.
Assia TianeDepartment of Immunology and Biochemistry, Biomedical research institute, Hasselt University, Martelarenlaan 42, 3500, Hasselt, Belgium.
Ann CuypersCentre for Environmental Sciences, Hasselt University, Martelarenlaan 42, 3500, Hasselt, Belgium.
Frank LeijtenDepartment of Internal Medicine, Laboratory of Vascular Medicine, Erasmus University Medical Center, Wytemaweg 80, 3015 CN, Rotterdam, The Netherlands.
Yupyn ChintapakornCenter of Excellence in Environment and Plant Physiology, Department of Botany, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand.
Thiti SuttiyutCenter of Excellence in Environment and Plant Physiology, Department of Botany, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand.
Surachai PornpakakulDepartment of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand.
Dicky StruikSection of Molecular Metabolism and Nutrition, Department of Pediatrics, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands.
Anja KerksiekInstitute for Clinical Chemistry and Clinical Pharmacology, Sigmund-Freud-Str. 25, D-53127, Bonn, Germany.
Hong-Bing LiuKey Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Yushan Road 5, 266003, Qingdao, China.
Niels HellingsDepartment of Immunology and Biochemistry, Biomedical research institute, Hasselt University, Martelarenlaan 42, 3500, Hasselt, Belgium.
Pilar Martinez-MartinezSchool for mental health and neuroscience, Maastricht University, Universiteitssingel 50, 6229ER, Maastricht, The Netherlands.
Johan W JonkerSection of Molecular Metabolism and Nutrition, Department of Pediatrics, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands.
Ilse DewachterDepartment of Immunology and Biochemistry, Biomedical research institute, Hasselt University, Martelarenlaan 42, 3500, Hasselt, Belgium.
Eric SijbrandsDepartment of Internal Medicine, Laboratory of Vascular Medicine, Erasmus University Medical Center, Wytemaweg 80, 3015 CN, Rotterdam, The Netherlands.ORCID 0000-0001-8857-7389
Jochen WalterDepartment of Neurology, Molecular Cell Biology, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany.
Jerome HendriksDepartment of Immunology and Biochemistry, Biomedical research institute, Hasselt University, Martelarenlaan 42, 3500, Hasselt, Belgium.
Albert GroenDepartment of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.
Bart StaelsUniversity of Lille - EGID, Inserm, U1011, University Hospital CHU, Institut Pasteur de Lille, F-59019, Lille, France.
Dieter LütjohannInstitute for Clinical Chemistry and Clinical Pharmacology, Sigmund-Freud-Str. 25, D-53127, Bonn, Germany.
Tim VanmierloDepartment of Immunology and Biochemistry, Biomedical research institute, Hasselt University, Martelarenlaan 42, 3500, Hasselt, Belgium. tim.vanmierlo@uhasselt.be.ORCID 0000-0003-2912-0578
Monique MulderDepartment of Internal Medicine, Laboratory of Vascular Medicine, Erasmus University Medical Center, Wytemaweg 80, 3015 CN, Rotterdam, The Netherlands.
Hasselt University · BEMaastricht University · NLChulalongkorn University · THErasmus MC · NLUniversity Medical Center Groningen · NLAmsterdam UMC Location University of Amsterdam · NLInserm · FROcean University of China · CNUniversity of Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Activation of liver X receptors (LXRs) by synthetic agonists was found to improve cognition in Alzheimer's disease (AD) mice. However, these LXR agonists induce hypertriglyceridemia and hepatic steatosis, hampering their use in the clinic. We hypothesized that phytosterols as LXR agonists enhance cognition in AD without affecting plasma and hepatic triglycerides. Phytosterols previously reported to activate LXRs were tested in a luciferase-based LXR reporter assay. Using this assay, we found that phytosterols commonly present in a Western type diet in physiological concentrations do not activate LXRs. However, a lipid extract of the 24(S)-Saringosterol-containing seaweed Sargassum fusiforme did potently activate LXRβ. Dietary supplementation of crude Sargassum fusiforme or a Sargassum fusiforme-derived lipid extract to AD mice significantly improved short-term memory and reduced hippocampal Aβ plaque load by 81%. Notably, none of the side effects typically induced by full synthetic LXR agonists were observed. In contrast, administration of the synthetic LXRα activator, AZ876, did not improve cognition and resulted in the accumulation of lipid droplets in the liver. Administration of Sargassum fusiforme-derived 24(S)-Saringosterol to cultured neurons reduced the secretion of Aβ

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAniline CompoundsAnimalsAstrocytesCognitionCulture Media, ConditionedDisease Models, AnimalGene Expression RegulationGenes, ReporterHippocampusHumansLiver X ReceptorsLuciferasesMaleMemory, Short-TermAmyloid beta-Peptidesamyloid beta-protein (1-42)Aniline CompoundsAZ 876Culture Media, ConditionedLiver X ReceptorsLuciferasesNeuroprotective AgentsPeptide FragmentssaringosterolStigmasterolThiazoles

Identifiers

PMID30894635
PMCPMC6426980
OpenAlexW2923634234

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.