Evidence map›Paper›PMID 30896328›Full record

SynthesisCirculation. Genomic and precision medicine2019

Subsequent Event Risk in Individuals With Established Coronary Heart Disease.

Riyaz S Patel, Vinicius Tragante, Amand F Schmidt, Raymond O McCubrey, Michael V Holmes, Laurence J Howe, Kenan Direk, Axel Åkerblom, Karin Leander, Salim S Virani and 171 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Circulation. Genomic and precision medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Article
  6. Human Genomics and Drug Development.Cold Spring Harbor perspectives in medicine · 2022
    Review
  7. Mendelian Randomization: Concepts and Scope.Cold Spring Harbor perspectives in medicine · 2022
    Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. "International journal of molecular sciences · 2019
    Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

181 authors.

Riyaz S PatelInstitute of Cardiovascular Science (R.S.P., A.F.S., L.J.H., K.D., J.D., A.D.H., F.W.A), Faculty of Population Health Science, University College London, United Kingdom.
Vinicius TraganteDivision of Heart and Lungs, Department of Cardiology (V.T., A.F.S.,D.K.,F.W.A.), UMC Utrecht, the Netherlands.
Amand F SchmidtInstitute of Cardiovascular Science (R.S.P., A.F.S., L.J.H., K.D., J.D., A.D.H., F.W.A), Faculty of Population Health Science, University College London, United Kingdom.
Raymond O McCubreyIntermountain Heart Institute, Intermountain Medical Center, Salt Lake City, UT (R.O.M., J.F.C., J.B.M., J.L.A., B.D.H).
Michael V HolmesClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, Medical Research Council Population Health Research Unit, University of Oxford, United Kingdom (M.V.H).
Laurence J HoweInstitute of Cardiovascular Science (R.S.P., A.F.S., L.J.H., K.D., J.D., A.D.H., F.W.A), Faculty of Population Health Science, University College London, United Kingdom.
Kenan DirekInstitute of Cardiovascular Science (R.S.P., A.F.S., L.J.H., K.D., J.D., A.D.H., F.W.A), Faculty of Population Health Science, University College London, United Kingdom.
Axel ÅkerblomUppsala Clinical Research Center, Sweden (A. Åkerblom, N.E., S.J., C.H., B.L., D. Lindholm, A. Siegbahn, L.W.).
Karin LeanderInstitute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden (K.L., B.G., U.d.F.).
Salim S ViraniSection of Cardiology, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX (S.S.V.).
Karol A KaminskiDepartment of Population Medicine and Civilization Disease Prevention (K.A.K.), Medical University of Bialystok, Poland.
Jochen D MuehlschlegelDepartment of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA (J.D.M., M.H.).
Hooman AllayeeDepartments of Preventive Medicine and Biochemistry and Molecular Medicine (H.A., J.H.), Keck School of Medicine of USC, Los Angeles, CA.
Peter AlmgrenDepartment of Clinical Sciences, Lund University, Malmö, Sweden (P.A., O.M.).
Maris AlverEstonian Genome Centre, Department of Biotechnology, Institute of Genomics, Institute of Molecular and Cell Biology, University of Tartu, Estonia (M.A., A.M.).
Ekaterina V BaranovaDivision of Pharmacoepidemiology and Clinical Pharmacology, Utrecht University, the Netherlands (E.V.B., O.H.K., A.H.M.-v.d.Z.).
Hassan BehlouiCentre for Outcomes Research and Evaluation, Research Institute of the McGill University Health Centre, Montreal, QC, Canada (H.B., L.D., L.P., G.T., J.M.B.).
Bram BoeckxLaboratory for Translational Genetics, Department of Human Genetics (B.B., D. Lambrechts), Katholieke Universiteit Leuven, Belgium.
Peter S BraundDepartment of Cardiovascular Sciences, BHF Cardiovascular Research Centre, University of Leicester, United Kingdom (P.S.B., C.P.N., N.J.S.).
Lutz P BreitlingDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg (L.P.B., U.M.).
Graciela DelgadoFifth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Germany (G.D., M. Kleber, W.M.).
Nubia E DuarteHeart Institute, University of Sao Paulo, Brazil (N.E.D., A.C.P.).
Marie-Pierre DubéMontreal Heart Institute, OC, Canada (M.-P.D., J.-C.T.).
Line DufresneCentre for Outcomes Research and Evaluation, Research Institute of the McGill University Health Centre, Montreal, QC, Canada (H.B., L.D., L.P., G.T., J.M.B.).
Niclas ErikssonUppsala Clinical Research Center, Sweden (A. Åkerblom, N.E., S.J., C.H., B.L., D. Lindholm, A. Siegbahn, L.W.).
Luisa FocoInstitute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy (L.F.).
Markus ScholzInstitute for Medical Informatics, Statistics, and Epidemiology (M.S.), University of Leipzig, Germany.
Crystel M GijsbertsLaboratory of Experimental Cardiology (C.M.G.), UMC Utrecht, the Netherlands.
Charlotte GlingeDepartment of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet (C.G., T.E., R.J.).
Yan GongDepartment of Pharmacotherapy and Translational Research, Centre for Pharmacogenomics (Y.G., R.M.C.-D., J.A.J.), University of Florida, Gainesville.
Jaana HartialaInstitute for Genetic Medicine (J.H.), Keck School of Medicine of USC, Los Angeles, CA.
Mahyar HeydarpourDepartment of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA (J.D.M., M.H.).
Jaroslav A HubacekCentre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic (J.A.H., J.P.).
Marcus KleberFifth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Germany (G.D., M. Kleber, W.M.).
Daniel KofinkDivision of Heart and Lungs, Department of Cardiology (V.T., A.F.S.,D.K.,F.W.A.), UMC Utrecht, the Netherlands.
Salma KottiAssistance Publique-Hôpitaux de Paris (AP-HP), Department of Clinical Pharmacology, Platform of Clinical Research of East Paris (URCEST-CRCEST-CRB HUEP-UPMC), France (S.K.).
Pekka KuukasjärviDepartment of Cardio-Thoracic Surgery (P.K.), University of Tampere, Finland.
Vei-Vei LeeDepartment of Biostatistics and Epidemiology, Texas Heart Institute, Houston (V.-V.L.).
Andreas LeihererVorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch, Austria (A. Leiherer, C.H.S., H.D.).
Petra A LenziniStatistical Genomics Division, Department of Genetics (P.A. Lenzini, S.C.), Washington University School of Medicine, Saint Louis, MO.
Daniel LevinDivision of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Scotland, United Kingdom (D. Levin, I.R.M., C.C.L.).
Leo-Pekka LyytikäinenDepartment of Clinical Chemistry (L.-P.L., T.L.), University of Tampere, Finland.
Nicola MartinelliDepartment of Medicine, University of Verona, Italy (N.M., D.G., O.O.).
Ute MonsDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg (L.P.B., U.M.).
Christopher P NelsonDepartment of Cardiovascular Sciences, BHF Cardiovascular Research Centre, University of Leicester, United Kingdom (P.S.B., C.P.N., N.J.S.).
Kjell NikusDepartment of Cardiology (K.N.), University of Tampere, Finland.
Anna P PilbrowThe Christchurch Heart Institute, University of Otago Christchurch, New Zealand (A.P.P., A.M.R., V.A.C.).
Rafal PloskiDepartment of Medical Genetics (R. Ploski), Medical University of Warsaw, Poland.
Yan V SunDepartment of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA (Y.V.S.).
Michael W T TanckAmsterdam UMC, University of Amsterdam, Clinical Epidemiology and Biostatistics, The Netherlands (M.W.T.T.).
W H Wilson TangDepartment of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, OH (W.H.W.T., S.L.H.).
Stella TrompetSection of Gerontology and Geriatrics, Department of Internal Medicine (S.T.), Leiden University Medical Centre, the Netherlands.
Sander W van der LaanDivision Laboratories, Pharmacy, and Biomedical Genetics, Laboratory of Clinical Chemistry and Hematology (S.W.v.d.L.), UMC Utrecht, Utrecht University, the Netherlands.
Jessica Van SettenDivision Heart and Lungs, Department of Cardiology, UMC Utrecht, University of Utrecht, the Netherlands (J.V.S.).
Ragnar O VilmundarsonRuddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, ON, Canada (R.O.V., R.M., A.F.R.S.).
Chiara Viviani AnselmiDepartment of Cardiovascular Medicine, Humanitas Clinical and Research Centre, Milan, Italy (C.V.A., G.C.).
Efthymia VlachopoulouTransplantation Laboratory (E.V., M.-L.L.), Helsinki University Hospital and University of Helsinki, Finland.
Lawien Al AliUniversity Medical Centre, University of Groningen, the Netherlands (L.A.A., P.V.d.H.).
Eric BoerwinkleUniversity of Texas School of Public Health, Houston(E.B.).
Carlo BriguoriClinica Mediterranea, Naples, Italy (C.B.).
John F CarlquistIntermountain Heart Institute, Intermountain Medical Center, Salt Lake City, UT (R.O.M., J.F.C., J.B.M., J.L.A., B.D.H).
Kathryn F CarruthersQMRI, Cardiovascular Sciences, University of Edinburgh, United Kingdom (K.F.C.).
Gavino CasuDepartment of Cardiovascular Medicine, Humanitas Clinical and Research Centre, Milan, Italy (C.V.A., G.C.).
John DeanfieldInstitute of Cardiovascular Science (R.S.P., A.F.S., L.J.H., K.D., J.D., A.D.H., F.W.A), Faculty of Population Health Science, University College London, United Kingdom.
Panos DeloukasWilliam Harvey Research Institute, Barts and the London Medical School (P.D), Queen Mary University of London, United Kingdom.
Frank DudbridgeDepartment of Health Sciences, University of Leicester, United Kingdom (F.D.).
Thomas EngstrømDepartment of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet (C.G., T.E., R.J.).
Natalie FitzpatrickInstitute of Health Informatics (N.F., A. Timmis, H.H., F.W.A.), Faculty of Population Health Science, University College London, United Kingdom.
Kim FoxNational Heart and Lung Institute, Imperial College and Institute of Cardiovascular Medicine and Science, Royal Brompton Hospital, London, United Kingdom (K.F.).
Bruna GiganteInstitute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden (K.L., B.G., U.d.F.).
Stefan JamesUppsala Clinical Research Center, Sweden (A. Åkerblom, N.E., S.J., C.H., B.L., D. Lindholm, A. Siegbahn, L.W.).
Marja-Liisa LokkiTransplantation Laboratory (E.V., M.-L.L.), Helsinki University Hospital and University of Helsinki, Finland.
Paulo A LotufoCentro de Pesquisa Clinica, Hospital Universitario, Universidade de Sao Paulo, São Paulo, Brazil (P.A. Lotufo, ).
Nicola MarzilianoATS Sardegna, ASL 3 Nuoro, Nuoro, Italy (N. Marziliano).
Ify R MordiDivision of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Scotland, United Kingdom (D. Levin, I.R.M., C.C.L.).
Joseph B MuhlesteinIntermountain Heart Institute, Intermountain Medical Center, Salt Lake City, UT (R.O.M., J.F.C., J.B.M., J.L.A., B.D.H).
Christopher Newton-ChehCardiovascular Research Center, Center for Human Genetic Research, Massachusetts General Hospital, Boston (C.N.-C.).
Jan PithaCentre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic (J.A.H., J.P.).
Christoph H SaelyVorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch, Austria (A. Leiherer, C.H.S., H.D.).
Ayman Samman-TahhanDivision of Cardiology, Department of Medicine (A.S.-T., P.B.S., A.A.Q.), Emory Clinical Cardiovascular Research Institute, Emory University School of Medicine, Atlanta, GA.
Pratik B SandesaraDivision of Cardiology, Department of Medicine (A.S.-T., P.B.S., A.A.Q.), Emory Clinical Cardiovascular Research Institute, Emory University School of Medicine, Atlanta, GA.
Andrej TerenLIFE Research Centre for Civilization Diseases (M.S., A. Teren, R.B., J.T.), University of Leipzig, Germany.
Adam TimmisInstitute of Health Informatics (N.F., A. Timmis, H.H., F.W.A.), Faculty of Population Health Science, University College London, United Kingdom.
Frans Van de WerfDepartment of Cardiovascular Sciences (F.V.d.W.), Katholieke Universiteit Leuven, Belgium.
Els WautersRespiratory Oncology Unit, Department of Respiratory Medicine, University Hospitals KU Leuven, Belgium (E.W.).
Arthur A M WildeAmsterdam UMC, University of Amsterdam, Clinical and Experimental Cardiology, Amsterdam Cardiovascular Sciences, AMC Heart Center, the Netherlands (C.G., A.A.M.W., C.R.B.).
Ian FordRobertson Centre for Biostatistics, University of Glasgow, United Kingdom (I.F.).
David J StottInstitute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom (D.J.S., N.S.).
Ale AlgraDepartment of Neurology and Neurosurgery, Brain Centre Rudolf Magnus and Julius Centre for Health Sciences and Primary Care (A. Algra), UMC Utrecht, Utrecht University, the Netherlands.
Maria G AndreassiCNR Institute of Clinical Physiology, Pisa (M.G.A, C.C).
Diego ArdissinoCardiology Department, Parma University Hospital, Italy (D.A.).
Benoit J ArsenaultCentre de recherche de l'Institut Universitaire de cardiologie et de pneumologie de Québec, Canada (B.J.A.).
Christie M BallantyneSection of Cardiovascular Research, Department of Medicine, Baylor College of Medicine, Houston, TX (S.S.V., C.M.B.).
Thomas O BergmeijerSt Antonius Hospital, Department Cardiology, Nieuwegein, the Netherlands (T.O.B., B.K.M., J.M.t.B.).
Connie R BezzinaAmsterdam UMC, University of Amsterdam, Clinical and Experimental Cardiology, Amsterdam Cardiovascular Sciences, AMC Heart Center, the Netherlands (C.G., A.A.M.W., C.R.B.).
Simon C BodyHarvard Medical School, Boston, MA (J.D.M., M.H., S.C.B).
Eric H BoersmaDepartment of Cardiology, Erasmus MC, Thoraxcenter (E.H.B., J.J.B.).
Peter BogatyLaval University, Institute universitaire de cardiologie et de pneumologie de Québec, Canada (P.B.).
Michiel L BotsJulius Center for Health Sciences and Primary Care (M.B., D.E.G., Y.v.d.G.), UMC Utrecht, Utrecht University, the Netherlands.
Hermann BrennerNetwork Aging Research (NAR), University of Heidelberg (H.B.).
Jasper J BrugtsDepartment of Cardiology, Erasmus MC, Thoraxcenter (E.H.B., J.J.B.).
Ralph BurkhardtLIFE Research Centre for Civilization Diseases (M.S., A. Teren, R.B., J.T.), University of Leipzig, Germany.
Clara CarpeggianiCNR Institute of Clinical Physiology, Pisa (M.G.A, C.C).
Gianluigi CondorelliInstitute of Cardiovascular Science (R.S.P., A.F.S., L.J.H., K.D., J.D., A.D.H., F.W.A), Faculty of Population Health Science, University College London, United Kingdom.
Rhonda M Cooper-DeHoffDepartment of Pharmacotherapy and Translational Research, Centre for Pharmacogenomics (Y.G., R.M.C.-D., J.A.J.), University of Florida, Gainesville.
Sharon CresciStatistical Genomics Division, Department of Genetics (P.A. Lenzini, S.C.), Washington University School of Medicine, Saint Louis, MO.
Nicolas DanchinAssistance Publique-Hôpitaux de Paris (AP-HP), Department of Cardiology, Hôpital Européen Georges Pompidou & FACT (French Alliance For Cardiovascular Trials), Université Paris Descartes, France (N.D.).
Ulf de FaireInstitute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden (K.L., B.G., U.d.F.).
Robert N DoughtyHeart Health Research Group, University of Auckland, New Zealand (R.N.D.).
Heinz DrexelVorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch, Austria (A. Leiherer, C.H.S., H.D.).
James C EngertResearch Institute of the McGill University Health Centre, Montreal, QC, Canada (J.C.E.).
Keith A A FoxThe University of Edinburgh, United Kingdom (K.A.A.F).
Domenico GirelliDepartment of Medicine, University of Verona, Italy (N.M., D.G., O.O.).
Diederick E GrobbeeJulius Center for Health Sciences and Primary Care (M.B., D.E.G., Y.v.d.G.), UMC Utrecht, Utrecht University, the Netherlands.
Emil HagströmDepartment of Cardiology, Uppsala Clinical Research Centre, Uppsala University, Sweden (E.H.).
Stanley L HazenDepartment of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, OH (W.H.W.T., S.L.H.).
Claes HeldUppsala Clinical Research Center, Sweden (A. Åkerblom, N.E., S.J., C.H., B.L., D. Lindholm, A. Siegbahn, L.W.).
Harry HemingwayInstitute of Cardiovascular Science (R.S.P., A.F.S., L.J.H., K.D., J.D., A.D.H., F.W.A), Faculty of Population Health Science, University College London, United Kingdom.
Imo E HoeferDepartment of Clinical Chemistry and Hematology (I.E.H.), UMC Utrecht, the Netherlands.
G Kees HovinghDepartment of Vascular Medicine, Academic Medical Centre, Amsterdam (G.K.H.).
Reza JabbariDepartment of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet (C.G., T.E., R.J.).
Julie A JohnsonDepartment of Pharmacotherapy and Translational Research, Centre for Pharmacogenomics (Y.G., R.M.C.-D., J.A.J.), University of Florida, Gainesville.
J Wouter JukemaDepartment of Cardiology (S.T., J.W.J.), Leiden University Medical Centre, the Netherlands.
Marcin P KaczorDepartment of Internal Medicine, Jagiellonian University Medical College, Kraków, Poland (M.P.K., M.S., W.S).
Mika KähönenDepartment of Clinical Physiology (M. Kähönen), University of Tampere, Finland.
Jiri KettnerCardiology Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic (J.K.).
Marek KiliszekDepartment of Cardiology and Internal Diseases, Military Institute of Medicine, Warsaw, Poland (M. Kiliszek).
Olaf H KlungelDivision of Pharmacoepidemiology and Clinical Pharmacology, Utrecht University, the Netherlands (E.V.B., O.H.K., A.H.M.-v.d.Z.).
Bo LagerqvistUppsala Clinical Research Center, Sweden (A. Åkerblom, N.E., S.J., C.H., B.L., D. Lindholm, A. Siegbahn, L.W.).
Diether LambrechtsLaboratory for Translational Genetics, Department of Human Genetics (B.B., D. Lambrechts), Katholieke Universiteit Leuven, Belgium.
Jari O LaurikkaDepartment of Cardio-Thoracic Surgery, Finnish Cardiovascular Research Center, Faculty of Medicine & Life Sciences (J.O.L.), University of Tampere, Finland.
Terho LehtimäkiDepartment of Clinical Chemistry (L.-P.L., T.L.), University of Tampere, Finland.
Daniel LindholmUppsala Clinical Research Center, Sweden (A. Åkerblom, N.E., S.J., C.H., B.L., D. Lindholm, A. Siegbahn, L.W.).
B K MahmoodiSt Antonius Hospital, Department Cardiology, Nieuwegein, the Netherlands (T.O.B., B.K.M., J.M.t.B.).
Anke H Maitland-van der ZeeDivision of Pharmacoepidemiology and Clinical Pharmacology, Utrecht University, the Netherlands (E.V.B., O.H.K., A.H.M.-v.d.Z.).
Ruth McPhersonRuddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, ON, Canada (R.O.V., R.M., A.F.R.S.).
Olle MelanderDepartment of Clinical Sciences, Lund University, Malmö, Sweden (P.A., O.M.).
Andres MetspaluEstonian Genome Centre, Department of Biotechnology, Institute of Genomics, Institute of Molecular and Cell Biology, University of Tartu, Estonia (M.A., A.M.).
Anna Niemcunowicz-JanicaDepartment of Forensic Medicine; Medical University of Bialystok (A.N.-J.).
Oliviero OlivieriDepartment of Medicine, University of Verona, Italy (N.M., D.G., O.O.).
Grzegorz Opolskifirst Chair and Department of Cardiology (G.O.), Medical University of Warsaw, Poland.
Colin N PalmerPat Macpherson Centre for Pharmacogenetics and Pharmacogenomics, Division of Molecular and Clinical Medicine, Ninewells Hospital and Medical School, Dundee (C.N.P.).
Gerard PasterkampDepartment of Clinical Chemistry (G.P.), UMC Utrecht, the Netherlands.
Carl J PepineDivision of Cardiovascular Medicine, College of Medicine (R.M.C.-D., J.A.J., C.J.P.), University of Florida, Gainesville.
Alexandre C PereiraHeart Institute, University of Sao Paulo, Brazil (N.E.D., A.C.P.).
Louise PiloteCentre for Outcomes Research and Evaluation, Research Institute of the McGill University Health Centre, Montreal, QC, Canada (H.B., L.D., L.P., G.T., J.M.B.).
Arshed A QuyyumiDivision of Cardiology, Department of Medicine (A.S.-T., P.B.S., A.A.Q.), Emory Clinical Cardiovascular Research Institute, Emory University School of Medicine, Atlanta, GA.
A Mark RichardsThe Christchurch Heart Institute, University of Otago Christchurch, New Zealand (A.P.P., A.M.R., V.A.C.).
Marek SanakDepartment of Internal Medicine, Jagiellonian University Medical College, Kraków, Poland (M.P.K., M.S., W.S).
Agneta SiegbahnUppsala Clinical Research Center, Sweden (A. Åkerblom, N.E., S.J., C.H., B.L., D. Lindholm, A. Siegbahn, L.W.).
Tabassome SimonAssistance Publique-Hôpitaux de Paris (AP-HP), Department of Clinical Pharmacology, Platform of Clinical Research of East Paris (URCEST-CRCEST-CRB HUEP-UPMC), FACT (French Alliance for Cardiovascular Trials), Sorbonne Université (T.S.).
Juha SinisaloHeart and Lung Centre (J.S.), Helsinki University Hospital and University of Helsinki, Finland.
J Gustav SmithDepartment of Cardiology, Clinical Sciences, Lund University, Skåne University Hospital (J.G.S.).
John A SpertusSaint Luke's Mid America Heart Institute, University of Missouri-Kansas City (J.A.S.).
Steen StenderDepartment of Clinical Biochemistry, Copenhagen University Hospital, Gentofte (S.S.).
Alexandre F R StewartRuddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, ON, Canada (R.O.V., R.M., A.F.R.S.).
Wojciech SzczeklikDepartment of Internal Medicine, Jagiellonian University Medical College, Kraków, Poland (M.P.K., M.S., W.S).
Anna SzpakowiczDepartment of Cardiology (K.A.K., A. Szpakowicz), Medical University of Bialystok, Poland.
Jean-Claude TardifMontreal Heart Institute, OC, Canada (M.-P.D., J.-C.T.).
Jurriën M Ten BergSt Antonius Hospital, Department Cardiology, Nieuwegein, the Netherlands (T.O.B., B.K.M., J.M.t.B.).
Jacob Tfelt-HansenDepartment of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet (J.T.-H.).
George ThanassoulisCentre for Outcomes Research and Evaluation, Research Institute of the McGill University Health Centre, Montreal, QC, Canada (H.B., L.D., L.P., G.T., J.M.B.).
Joachim ThieryLIFE Research Centre for Civilization Diseases (M.S., A. Teren, R.B., J.T.), University of Leipzig, Germany.
Christian Torp-PedersenUnit of Epidemiology and Biostatistics, Department of Health Science and Technology, Aalborg University Hospital, Denmark (C.T.-Pedersen).
Yolanda van der GraafJulius Center for Health Sciences and Primary Care (M.B., D.E.G., Y.v.d.G.), UMC Utrecht, Utrecht University, the Netherlands.
Frank L J VisserenDepartment of Vascular Medicine (F.L.J.V), UMC Utrecht, Utrecht University, the Netherlands.
Johannes WaltenbergerDepartment of Cardiovascular Medicine, University of Münster, Germany (J.W.).
Peter E WeekeDepartment of Cardiology, Herlev and Gentofte Hospital, Hellerup, Denmark (P.E.W.).
Pim Van der HarstUniversity Medical Centre, University of Groningen, the Netherlands (L.A.A., P.V.d.H.).
Chim C LangDivision of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Scotland, United Kingdom (D. Levin, I.R.M., C.C.L.).
Naveed SattarInstitute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom (D.J.S., N.S.).
Vicky A CameronThe Christchurch Heart Institute, University of Otago Christchurch, New Zealand (A.P.P., A.M.R., V.A.C.).
Jeffrey L AndersonIntermountain Heart Institute, Intermountain Medical Center, Salt Lake City, UT (R.O.M., J.F.C., J.B.M., J.L.A., B.D.H).
James M BrophyCentre for Outcomes Research and Evaluation, Research Institute of the McGill University Health Centre, Montreal, QC, Canada (H.B., L.D., L.P., G.T., J.M.B.).
Guillaume PareDepartment of Pathology and Molecular Medicine, McMaster University (G.P.).
Benjamin D HorneIntermountain Heart Institute, Intermountain Medical Center, Salt Lake City, UT (R.O.M., J.F.C., J.B.M., J.L.A., B.D.H).
Winfried MärzFifth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Germany (G.D., M. Kleber, W.M.).
Lars WallentinUppsala Clinical Research Center, Sweden (A. Åkerblom, N.E., S.J., C.H., B.L., D. Lindholm, A. Siegbahn, L.W.).
Nilesh J SamaniDepartment of Cardiovascular Sciences, BHF Cardiovascular Research Centre, University of Leicester, United Kingdom (P.S.B., C.P.N., N.J.S.).
Aroon D HingoraniInstitute of Cardiovascular Science (R.S.P., A.F.S., L.J.H., K.D., J.D., A.D.H., F.W.A), Faculty of Population Health Science, University College London, United Kingdom.
Folkert W AsselbergsInstitute of Health Informatics (N.F., A. Timmis, H.H., F.W.A.), Faculty of Population Health Science, University College London, United Kingdom.

Funding

Structural Determinants Of Ceruloplasmin Inflammatory ActivityP01HL076491 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI PLOW, EDWARD FRANKLIN · 2004 to 2019
$27.3M
Pharmacogenomic Evaluation of Antihypertensive ResponsesU01GM074492 · NIGMS · UNIVERSITY OF FLORIDA · PI COOPER-DEHOFF, RHONDA M, JOHNSON, JULIE A. · 2005 to 2014
$20.7M
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British Heart Foundation FS/14/76/30933British Heart Foundation FS/18/23/33512British Heart Foundation PG/18/50/33837British Heart Foundation PG/18/5033837British Heart Foundation RG/14/5/30893Chief Scientist Office PCL 17/07Chief Scientist Office PCL/17/07CIHRDepartment of HealthEuropean Research Council 335122Medical Research CouncilNHLBI NIH HHS P01 HL076491NHLBI NIH HHS P01 HL101398NHLBI NIH HHS P50 HL077113NHLBI NIH HHS R01 HL074730NHLBI NIH HHS R01 HL133169NHLBI NIH HHS R56 HL126558NIEHS NIH HHS P01 ES022845NIEHS NIH HHS R01 ES025786NIGMS NIH HHS U01 GM074492NINR NIH HHS R01 NR013396Wellcome Trust 072960/Z/03/ZWellcome Trust 084726/Z/08/ZWellcome Trust 084727/Z/08/ZWellcome Trust 085475/B/08/ZWellcome Trust 085475/Z/08/Z
6 · The paper itself

Abstract

backgroundThe Genetics of Subsequent Coronary Heart Disease (GENIUS-CHD) consortium was established to facilitate discovery and validation of genetic variants and biomarkers for risk of subsequent CHD events, in individuals with established CHD.

methodsThe consortium currently includes 57 studies from 18 countries, recruiting 185 614 participants with either acute coronary syndrome, stable CHD, or a mixture of both at baseline. All studies collected biological samples and followed-up study participants prospectively for subsequent events.

resultsEnrollment into the individual studies took place between 1985 to present day with a duration of follow-up ranging from 9 months to 15 years. Within each study, participants with CHD are predominantly of self-reported European descent (38%-100%), mostly male (44%-91%) with mean ages at recruitment ranging from 40 to 75 years. Initial feasibility analyses, using a federated analysis approach, yielded expected associations between age (hazard ratio, 1.15; 95% CI, 1.14-1.16) per 5-year increase, male sex (hazard ratio, 1.17; 95% CI, 1.13-1.21) and smoking (hazard ratio, 1.43; 95% CI, 1.35-1.51) with risk of subsequent CHD death or myocardial infarction and differing associations with other individual and composite cardiovascular endpoints.

conclusionsGENIUS-CHD is a global collaboration seeking to elucidate genetic and nongenetic determinants of subsequent event risk in individuals with established CHD, to improve residual risk prediction and identify novel drug targets for secondary prevention. Initial analyses demonstrate the feasibility and reliability of a federated analysis approach. The consortium now plans to initiate and test novel hypotheses as well as supporting replication and validation analyses for other investigators.

Indexed as

AdultAgedAge FactorsCoronary DiseaseFemaleHumansMaleMiddle AgedPrognosisProportional Hazards ModelsRisk FactorsSex FactorsSmokingcoronary artery diseasegeneticsmyocardial infarctionprognosissecondary prevention

Identifiers

PMID30896328
PMCPMC6629546

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.