Evidence map›Paper›PMID 30897348›Full record

SynthesisCirculation. Genomic and precision medicine2019

Association of Chromosome 9p21 With Subsequent Coronary Heart Disease Events.

Riyaz S Patel, Amand F Schmidt, Vinicius Tragante, Raymond O McCubrey, Michael V Holmes, Laurence J Howe, Kenan Direk, Axel Åkerblom, Karin Leander, Salim S Virani and 158 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Circulation. Genomic and precision medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

168 authors.

Riyaz S PatelInstitute of Cardiovascular Science, Faculty of Population Health Science (R.S.P., A.F.S., L.J.H., K.D., J.D., A.D.H., F.W.A.).
Amand F SchmidtInstitute of Cardiovascular Science, Faculty of Population Health Science (R.S.P., A.F.S., L.J.H., K.D., J.D., A.D.H., F.W.A.).
Vinicius TraganteDivision Heart and Lungs, Department of Cardiology (A.F.S., V.T. D.K., F.W.A.).
Raymond O McCubreyIntermountain Heart Institute, Intermountain Medical Center, Salt Lake City, UT (R.O.M., J.F.C., J.B.M., J.L.A.).
Michael V HolmesClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health (M.V.H.), University of Oxford, United Kingdom.
Laurence J HoweInstitute of Cardiovascular Science, Faculty of Population Health Science (R.S.P., A.F.S., L.J.H., K.D., J.D., A.D.H., F.W.A.).
Kenan DirekInstitute of Cardiovascular Science, Faculty of Population Health Science (R.S.P., A.F.S., L.J.H., K.D., J.D., A.D.H., F.W.A.).
Axel ÅkerblomUppsala Clinical Research Center (A.A., N.E., S.J., E.H., C.H., B.L., D. Lindholm, A. Siegbahn, L.W.), Uppsala University, Sweden.
Karin LeanderInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (K.L., U.d.F.).
Salim S ViraniSection of Cardiology, Michael E. DeBakey Veterans Affairs Medical Center, Section of Cardiovascular Research, and Department of Medicine, Baylor College of Medicine, Houston, TX (S.S.V., C.M.B.).
Karol A KaminskiDepartment of Population Medicine and Civilization Disease Prevention (K.A.K.).
Jochen D MuehlschlegelHarvard Medical School, Boston, MA (J.D.M., M.H. S.C.B.).
Marie-Pierre DubéUniversité de Montréal, QC, Canada (M.-P.D.).
Hooman AllayeeDepartments of Preventive Medicine and Biochemistry and Molecular Medicine (H.A., J.H.), Keck School of Medicine of USC, Los Angeles, CA.
Peter AlmgrenDepartment of Clinical Sciences, Lund University, Malmö, Sweden (P.A., O.M.).
Maris AlverDepartment of Biotechnology, Institute of Molecular and Cell Biology, University of Tartu, Estonia (M.A., A.M.).
Ekaterina V BaranovaDivision of Pharmacoepidemiology and Clinical Pharmacology (E.V.B., O.H.K., A.H.M.-v.d.Z.), University Medical Center Utrecht, the Netherlands.
Hassan BehlouliCentre for Outcomes Research and Evaluation, Research Institute of the McGill University Health Centre (H.B., L.D., L.P., J.M.B.).
Bram BoeckxLaboratory for Translational Genetics, Department of Human Genetics (B.B., D. Lambrechts).
Peter S BraundDepartment of Cardiovascular Sciences (P.S.B., C.P.N., N.J.S.) and Department of Health Sciences, University of Leicester, United Kingdom.
Lutz P BreitlingDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg (L.P.B., U.M., H.B.).
Graciela DelgadoVth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany (G.D., M. Kleber, W.M.).
Nubia E DuarteHeart Institute, University of Sao Paulo, Brazil (N.E.D., A.C.P.).
Line DufresneCentre for Outcomes Research and Evaluation, Research Institute of the McGill University Health Centre (H.B., L.D., L.P., J.M.B.).
Niclas ErikssonUppsala Clinical Research Center (A.A., N.E., S.J., E.H., C.H., B.L., D. Lindholm, A. Siegbahn, L.W.), Uppsala University, Sweden.
Luisa FocoInstitute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy (L.F.).
Crystel M GijsbertsLaboratory of Experimental Cardiology (C.M.G., B.D.H.).
Yan GongDepartment of Pharmacotherapy and Translational Research and Center for Pharmacogenomics (Y.G., R.M.C.-D., J.A.J.).
Jaana HartialaDepartments of Preventive Medicine and Biochemistry and Molecular Medicine (H.A., J.H.), Keck School of Medicine of USC, Los Angeles, CA.
Mahyar HeydarpourDepartment of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital (M.H.).
Jaroslav A HubacekCentre for Experimental Medicine, Institut for Clinical and Experimental Medicine, Prague, Czech Republic (J.A.H., J.P.).
Marcus KleberVth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany (G.D., M. Kleber, W.M.).
Daniel KofinkDivision Heart and Lungs, Department of Cardiology (A.F.S., V.T. D.K., F.W.A.).
Pekka KuukasjärviDepartment of Cardio-Thoracic Surgery (P.K.).
Vei-Vei LeeDepartment of Biostatistics and Epidemiology, Texas Heart Institute, Houston (V.-V.L.).
Andreas LeihererVorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch, Austria (A.L., C.H.S., H.D.).
Petra A LenziniDepartment of Genetics, Statistical Genomics Division (P.A.L., S.C.).
Daniel LevinDivision of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Scotland, United Kingdom (D. Levin, I.R.M., C.C.L.).
Leo-Pekka LyytikäinenDepartment of Clinical Chemistry (L.-P.L., T.L.).
Nicola MartinelliDepartment of Medicine, University of Verona, Italy (N. Martinelli, D.G., O.O.).
Ute MonsDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg (L.P.B., U.M., H.B.).
Christopher P NelsonDepartment of Cardiovascular Sciences (P.S.B., C.P.N., N.J.S.) and Department of Health Sciences, University of Leicester, United Kingdom.
Kjell NikusDepartment of Cardiology (K.N.).
Anna P PilbrowThe Christchurch Heart Institute, University of Otago Christchurch, New Zealand (A.P.B., A.M.R., V.A.C.).
Rafal PloskiDepartment of Medical Genetics (R.P.).
Yan V SunDepartment of Epidemiology, Emory University Rollins School of Public Health (Y.V.S.).
Michael W T TanckClinical Epidemiology and Biostatistics (M.W.T.T.).
W H Wilson TangDepartment of Cellular and Molecular Medicine, Lerner Research Institute (W.H.W.T., S.L.H.).
Stella TrompetSection of Gerontology and Geriatrics, Department of Internal Medicine (S.T.), Leiden University Medical Center.
Sander W van der LaanLaboratory of Clinical Chemistry and Hematology, Division Laboratories, Pharmacy, and Biomedical Genetics (S.W.v.d.L.).
Jessica van SettenDurrer Centre of Cardiogenetic Research, ICIN-Netherlands Heart Institute, Netherlands (J.v.S., F.W.B.).
Ragnar O VilmundarsonRuddy Canadian Cardiovascular Genetics Centre (R.O.V., A.F.R.S.).
Chiara Viviani AnselmiDepartment of Cardiovascular Medicine, Humanitas Clinical and Research Center, Milan, Italy (C.V.A., G.C).
Efthymia VlachopoulouTransplantation Laboratory, Medicum (E.V., M.-L.L.).
Eric BoerwinkleUniversity of Texas School of Public Health, Houston (E.B.).
Carlo BriguoriClinica Mediterranea, Naples, Italy (C.B.).
John F CarlquistIntermountain Heart Institute, Intermountain Medical Center, Salt Lake City, UT (R.O.M., J.F.C., J.B.M., J.L.A.).
Kathryn F CarruthersCardiovascular Sciences (K.F.C.), University of Edinburgh.
Gavino CasuDepartment of Cardiovascular Medicine, Humanitas Clinical and Research Center, Milan, Italy (C.V.A., G.C).
John DeanfieldInstitute of Cardiovascular Science, Faculty of Population Health Science (R.S.P., A.F.S., L.J.H., K.D., J.D., A.D.H., F.W.A.).
Panos DeloukasWilliam Harvey Research Institute, Barts and the London Medical School (P.D.), Queen Mary University of London.
Frank DudbridgeBHF Cardiovascular Research Centre (F.D.), Glenfield Hospital, Leicester, United Kingdom.
Natalie FitzpatrickInstitute of Health Informatics, Faculty of Population Health Science, University College London, United Kingdom (N.F., C.H.S., A. Timmis, H.H., F.W.A.).
Bruna GiganteDepartment of Clinical Chemistry and Hematology (B.G., I.E.H.).
Stefan JamesUppsala Clinical Research Center (A.A., N.E., S.J., E.H., C.H., B.L., D. Lindholm, A. Siegbahn, L.W.), Uppsala University, Sweden.
Marja-Liisa LokkiTransplantation Laboratory, Medicum (E.V., M.-L.L.).
Paulo A LotufoCentro de Pesquisa Clinica, Hospital Universitario, Universidade de Sao Paulo, Brazil (P.A.L.).
Nicola MarzilianoATS Sardegna, ASL 3, Nuoro (G. Casu, N. Marziliano).
Ify R MordiDivision of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Scotland, United Kingdom (D. Levin, I.R.M., C.C.L.).
Joseph B MuhlesteinIntermountain Heart Institute, Intermountain Medical Center, Salt Lake City, UT (R.O.M., J.F.C., J.B.M., J.L.A.).
Chris Newton ChehCardiovascular Research Center and Center for Human Genetic Research, Massachusetts General Hospital, Boston and Program in Medical and Population Genetics, Broad Institute, Cambridge, MA (C.N.C.).
Jan PithaCentre for Experimental Medicine, Institut for Clinical and Experimental Medicine, Prague, Czech Republic (J.A.H., J.P.).
Christoph H SaelyInstitute of Health Informatics, Faculty of Population Health Science, University College London, United Kingdom (N.F., C.H.S., A. Timmis, H.H., F.W.A.).
Ayman Samman-TahhanDivision of Cardiology, Department of Medicine, Emory Clinical Cardiovascular Research Institute, Emory University School of Medicine, Atlanta, GA (A.S.-T., P.B.S., A.A.Q.).
Pratik B SandesaraDivision of Cardiology, Department of Medicine, Emory Clinical Cardiovascular Research Institute, Emory University School of Medicine, Atlanta, GA (A.S.-T., P.B.S., A.A.Q.).
Andrej TerenDepartment of Medicine and Cardiology, Academic Teaching Hospital Feldkirch, Austria. Heart Center Leipzig (A. Teren).
Adam TimmisInstitute of Health Informatics, Faculty of Population Health Science, University College London, United Kingdom (N.F., C.H.S., A. Timmis, H.H., F.W.A.).
Frans Van de WerfDepartement of Cardiovascular Sciences, KU Leuven, Belgium (F.V.d.W.).
Els WautersRespiratory Oncology Unit, Department of Respiratory Medicine, University Hospitals KU Leuven, Belgium (E.W.).
Arthur A M WildeAMC Heart Center (A.A.M.W., C.R.B.).
Ian FordRobertson Center for Biostatistics (I.F.).
David J StottInstitute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom (D.J.S., N.S.).
Ale AlgraDepartment of Neurology and Neurosurgery, Brain Centre Rudolf Magnus and Julius Center for Health Sciences and Primary Care (A. Algra), University Medical Center Utrecht, the Netherlands.
Maria G AndreassiCNR Institute of Clinical Physiology, Pisa, Italy (M.G.A., C.C.).
Diego ArdissinoCardiology Department, Parma University Hospital, Italy (D.A.).
Benoit J ArsenaultCentre de recherche de l'Institut Universitaire de cardiologie et de pneumologie de Québec (B.J.A.).
Christie M BallantyneSection of Cardiology, Michael E. DeBakey Veterans Affairs Medical Center, Section of Cardiovascular Research, and Department of Medicine, Baylor College of Medicine, Houston, TX (S.S.V., C.M.B.).
Thomas O BergmeijerSt. Antonius Hospital, Department of Cardiology, Nieuwegein, the Netherlands (T.O.B., B.K.M., J.M.t.B.).
Connie R BezzinaAMC Heart Center (A.A.M.W., C.R.B.).
Simon C BodyHarvard Medical School, Boston, MA (J.D.M., M.H. S.C.B.).
Peter BogatyService de cardiologie, Département multidisciplinaire de cardiologie, Instituteitut universitaire de cardiologie et de pneumologie de Québec, Canada (P.B.).
Gert J de BorstDepartment of Vascular Surgery, University Medical Center Utrecht, University Utrecht, the Netherlands (G.J.d.B.).
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg (L.P.B., U.M., H.B.).
Ralph BurkhardtLIFE Research Center for Civilization Diseases (A. Teren, R.B., M. Scholz, J.T.).
Clara CarpeggianiCNR Institute of Clinical Physiology, Pisa, Italy (M.G.A., C.C.).
Gianluigi CondorelliDepartment of Biomedical Sciences, Humanitas University, Milan, Italy (G. Condorelli).
Rhonda M Cooper-DeHoffDepartment of Pharmacotherapy and Translational Research and Center for Pharmacogenomics (Y.G., R.M.C.-D., J.A.J.).
Sharon CresciDepartment of Genetics, Statistical Genomics Division (P.A.L., S.C.).
Ulf de FaireInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (K.L., U.d.F.).
Robert N DoughtyHeart Health Research Group, University of Auckland, New Zealand (R.N.D.).
Heinz DrexelVorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch, Austria (A.L., C.H.S., H.D.).
James C EngertResearch Institute of the McGill University Health Centre (J.C.E.).
Keith A A FoxEmeritus Professor of Cardiology (K.A.A.F.), University of Edinburgh.
Domenico GirelliDepartment of Medicine, University of Verona, Italy (N. Martinelli, D.G., O.O.).
Emil HagströmUppsala Clinical Research Center (A.A., N.E., S.J., E.H., C.H., B.L., D. Lindholm, A. Siegbahn, L.W.), Uppsala University, Sweden.
Stanley L HazenDepartment of Cellular and Molecular Medicine, Lerner Research Institute (W.H.W.T., S.L.H.).
Claes HeldUppsala Clinical Research Center (A.A., N.E., S.J., E.H., C.H., B.L., D. Lindholm, A. Siegbahn, L.W.), Uppsala University, Sweden.
Harry HemingwayInstitute of Health Informatics, Faculty of Population Health Science, University College London, United Kingdom (N.F., C.H.S., A. Timmis, H.H., F.W.A.).
Imo E HoeferDepartment of Clinical Chemistry and Hematology (B.G., I.E.H.).
G Kees HovinghDepartment of Vascular Medicine, Academic Medical Center, Amsterdam, the Netherlands (G.K.H.).
Julie A JohnsonDepartment of Pharmacotherapy and Translational Research and Center for Pharmacogenomics (Y.G., R.M.C.-D., J.A.J.).
Pim A de JongDepartment of Radiology (P.A.d.J.), University Medical Center Utrecht, the Netherlands.
J Wouter JukemaDepartment of Cardiology (S.T., J.W.J.), Leiden University Medical Center.
Marcin P KaczorDepartment of Internal Medicine, Jagiellonian University Medical College, Kraków, Poland (M.P.K., M. Sanak, W.S.).
Mika KähönenDepartment of Clinical Physiology (M. Kähönen).
Jiri KettnerCardiology Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic (J.K.).
Marek KiliszekDepartment of Cardiology and Internal Diseases, Military Institute of Medicine, Warsaw, Poland (M. Kiliszek).
Olaf H KlungelDivision of Pharmacoepidemiology and Clinical Pharmacology (E.V.B., O.H.K., A.H.M.-v.d.Z.), University Medical Center Utrecht, the Netherlands.
Bo LagerqvistUppsala Clinical Research Center (A.A., N.E., S.J., E.H., C.H., B.L., D. Lindholm, A. Siegbahn, L.W.), Uppsala University, Sweden.
Diether LambrechtsLaboratory for Translational Genetics, Department of Human Genetics (B.B., D. Lambrechts).
Jari O LaurikkaDepartment of Cardio-Thoracic Surgery, Finnish Cardiovascular Research Center, Faculty of Medicine and Life Sciences, University of Tampere (J.O.L.).
Terho LehtimäkiDepartment of Clinical Chemistry (L.-P.L., T.L.).
Daniel LindholmUppsala Clinical Research Center (A.A., N.E., S.J., E.H., C.H., B.L., D. Lindholm, A. Siegbahn, L.W.), Uppsala University, Sweden.
Bakhtawar K MahmoodiSt. Antonius Hospital, Department of Cardiology, Nieuwegein, the Netherlands (T.O.B., B.K.M., J.M.t.B.).
Anke H Maitland-van der ZeeDivision of Pharmacoepidemiology and Clinical Pharmacology (E.V.B., O.H.K., A.H.M.-v.d.Z.), University Medical Center Utrecht, the Netherlands.
Ruth McPhersonUniversity of Ottawa Heart Institute (R.M.).
Olle MelanderDepartment of Clinical Sciences, Lund University, Malmö, Sweden (P.A., O.M.).
Andres MetspaluEstonian Genome Center, Institute of Genomics (A.M.).
Witold PepinskiDepartment of Forensic Medicine, Medical University of Bialystok, Poland (W.P., G.T.).
Oliviero OlivieriDepartment of Medicine, University of Verona, Italy (N. Martinelli, D.G., O.O.).
Grzegorz OpolskiDepartment of Cardiology, Medical University of Warsaw, Poland (G.O.).
Colin N PalmerPat Macpherson Centre for Pharmacogenetics and Pharmacogenomics, Division of Molecular and Clinical Medicine, Ninewells Hospital and Medical School, Dundee (C.N.P.).
Gerard PasterkampDepartment of Clinical Chemistry, UMC Utrecht, Netherlands (G. Pasterkamp).
Carl J PepineDivision of Cardiovascular Medicine, College of Medicine, University of Florida (J.A.J., C.J.P.).
Alexandre C PereiraHeart Institute, University of Sao Paulo, Brazil (N.E.D., A.C.P.).
Louise PiloteCentre for Outcomes Research and Evaluation, Research Institute of the McGill University Health Centre (H.B., L.D., L.P., J.M.B.).
Arshed A QuyyumiDivision of Cardiology, Department of Medicine, Emory Clinical Cardiovascular Research Institute, Emory University School of Medicine, Atlanta, GA (A.S.-T., P.B.S., A.A.Q.).
A Mark RichardsThe Christchurch Heart Institute, University of Otago Christchurch, New Zealand (A.P.B., A.M.R., V.A.C.).
Marek SanakDepartment of Internal Medicine, Jagiellonian University Medical College, Kraków, Poland (M.P.K., M. Sanak, W.S.).
Markus ScholzLIFE Research Center for Civilization Diseases (A. Teren, R.B., M. Scholz, J.T.).
Agneta SiegbahnUppsala Clinical Research Center (A.A., N.E., S.J., E.H., C.H., B.L., D. Lindholm, A. Siegbahn, L.W.), Uppsala University, Sweden.
Juha SinisaloHeart and Lung Center, Helsinki University Hospital University of Helsinki, Finland (J.S.).
J Gustav SmithDepartment of Cardiology, Clinical Sciences, Lund University and Skåne University Hospital (J.G.S.), Lund University, Lund, Sweden.
John A SpertusSaint Luke's Mid America Heart Institute and the University of Missouri-Kansas City and Saint Luke's Health System, Kansas City, MO (J.A.S.).
Alexandre F R StewartRuddy Canadian Cardiovascular Genetics Centre (R.O.V., A.F.R.S.).
Wojciech SzczeklikDepartment of Internal Medicine, Jagiellonian University Medical College, Kraków, Poland (M.P.K., M. Sanak, W.S.).
Anna SzpakowiczDepartment of Cardiology (K.A.K., A. Szpakowicz).
Jurriën M Ten BergSt. Antonius Hospital, Department of Cardiology, Nieuwegein, the Netherlands (T.O.B., B.K.M., J.M.t.B.).
George ThanassoulisDepartment of Forensic Medicine, Medical University of Bialystok, Poland (W.P., G.T.).
Joachim ThieryLIFE Research Center for Civilization Diseases (A. Teren, R.B., M. Scholz, J.T.).
Yolanda van der GraafJulius Center for Health Sciences and Primary Care (Y.v.d.G.), University Medical Center Utrecht, the Netherlands.
Frank L J VisserenDepartment of Vascular Medicine, University Medical Center Utrecht and Utrecht University, the Netherlands (F.L.J.V.).
Johannes WaltenbergerDepartment of Cardiovascular Medicine, University of Münster, Germany (J.W.).
CARDIoGRAMPlusC4D Consortium
Pim Van der HarstCARDIoGRAMPlusC4D. University of Groningen, University Medical Center, Groningen, Netherlands (P.V.d.H.).
Jean-Claude TardifMontreal Heart Institute (J.-C.T.).
Naveed SattarInstitute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom (D.J.S., N.S.).
Chim C LangDivision of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Scotland, United Kingdom (D. Levin, I.R.M., C.C.L.).
Guillaume PareDepartment of Pathology and Molecular Medicine, McMaster University (G. Pare).
James M BrophyCentre for Outcomes Research and Evaluation, Research Institute of the McGill University Health Centre (H.B., L.D., L.P., J.M.B.).
Jeffrey L AndersonIntermountain Heart Institute, Intermountain Medical Center, Salt Lake City, UT (R.O.M., J.F.C., J.B.M., J.L.A.).
Winfried MärzVth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany (G.D., M. Kleber, W.M.).
Lars WallentinUppsala Clinical Research Center (A.A., N.E., S.J., E.H., C.H., B.L., D. Lindholm, A. Siegbahn, L.W.), Uppsala University, Sweden.
Vicky A CameronThe Christchurch Heart Institute, University of Otago Christchurch, New Zealand (A.P.B., A.M.R., V.A.C.).
Benjamin D HorneLaboratory of Experimental Cardiology (C.M.G., B.D.H.).
Nilesh J SamaniDepartment of Cardiovascular Sciences (P.S.B., C.P.N., N.J.S.) and Department of Health Sciences, University of Leicester, United Kingdom.
Aroon D HingoraniInstitute of Cardiovascular Science, Faculty of Population Health Science (R.S.P., A.F.S., L.J.H., K.D., J.D., A.D.H., F.W.A.).
Folkert W AsselbergsInstitute of Cardiovascular Science, Faculty of Population Health Science (R.S.P., A.F.S., L.J.H., K.D., J.D., A.D.H., F.W.A.).

Funding

Structural Determinants Of Ceruloplasmin Inflammatory ActivityP01HL076491 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI PLOW, EDWARD FRANKLIN · 2004 to 2019
$27.3M
Pharmacogenomic Evaluation of Antihypertensive ResponsesU01GM074492 · NIGMS · UNIVERSITY OF FLORIDA · PI COOPER-DEHOFF, RHONDA M, JOHNSON, JULIE A. · 2005 to 2014
$20.7M
Serious Hazards of Transfusion & Cellular Therapies: Mechanisms and InterventionP01HL086773 · NHLBI · EMORY UNIVERSITY · PI EASLEY, KIRK · 2008 to 2019
$17.9M
SCCOR in Cardiac Dysfunction and DiseaseP50HL077113 · NHLBI · WASHINGTON UNIVERSITY · PI CAIN, MICHAEL E · 2005 to 2009
$13.4M
Cell Interactions in the Inflamed Intestinal MucosaR01DK075787 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI JOEL N HIRSCHHORN · 2007 to 2026
$13.1M
Regression of Atherosclerosis CoreP01HL098055 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI HAZEN, STANLEY L · 2010 to 2014
$12.1M
Vascular Responses During Mental StressP01HL101398 · NHLBI · EMORY UNIVERSITY · PI QUYYUMI, ARSHED A · 2010 to 2015
$11.0M
Gut Flora Metabolism of Dietary Phosphatidylcholine and CVDR01HL103866 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI HAZEN, STANLEY L · 2010 to 2023
$10.8M
Cell therapy for diabetic peripheral neurovascular complicationsDP3DK094346 · NIDDK · EMORY UNIVERSITY · PI CHENG, XIAODONG, YOON, YOUNG-SUP · 2011 to 2011
$6.1M
The role of the renin-angiotensin-endothelial pathway in ADRF1AG051633 · NIA · EMORY UNIVERSITY · PI HAJJAR, IHAB M, QUYYUMI, ARSHED A · 2015 to 2017
$6.0M
Adverse effects of RBC transfusions: A unifying hypothesisR01HL095479 · NHLBI · EMORY UNIVERSITY · PI ROBACK, JOHN D · 2009 to 2017
$5.2M
Functional Cardio-MetabolomicsP20HL113452 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI HAZEN, STANLEY L, TANG, WAI HONG WILSON · 2012 to 2016
$4.8M
British Heart Foundation FS/14/76/30933British Heart Foundation FS/18/23/33512British Heart Foundation PG/18/50/33837British Heart Foundation PG/18/5033837British Heart Foundation RG/14/5/30893Chief Scientist Office PCL/17/07CIHRDepartment of HealthMedical Research CouncilNHLBI NIH HHS P01 HL076491NHLBI NIH HHS P50 HL077113NHLBI NIH HHS R01 HL074730NHLBI NIH HHS R01 HL133169NIGMS NIH HHS U01 GM074492NINR NIH HHS R01 NR013396Wellcome Trust 072960/Z/03/ZWellcome Trust 084726/Z/08/ZWellcome Trust 084727/Z/08/ZWellcome Trust 085475/B/08/ZWellcome Trust 085475/Z/08/Z
6 · The paper itself

Abstract

backgroundGenetic variation at chromosome 9p21 is a recognized risk factor for coronary heart disease (CHD). However, its effect on disease progression and subsequent events is unclear, raising questions about its value for stratification of residual risk.

methodsA variant at chromosome 9p21 (rs1333049) was tested for association with subsequent events during follow-up in 103 357 Europeans with established CHD at baseline from the GENIUS-CHD (Genetics of Subsequent Coronary Heart Disease) Consortium (73.1% male, mean age 62.9 years). The primary outcome, subsequent CHD death or myocardial infarction (CHD death/myocardial infarction), occurred in 13 040 of the 93 115 participants with available outcome data. Effect estimates were compared with case/control risk obtained from the CARDIoGRAMplusC4D consortium (Coronary Artery Disease Genome-wide Replication and Meta-analysis [CARDIoGRAM] plus The Coronary Artery Disease [C4D] Genetics) including 47 222 CHD cases and 122 264 controls free of CHD.

resultsMeta-analyses revealed no significant association between chromosome 9p21 and the primary outcome of CHD death/myocardial infarction among those with established CHD at baseline (GENIUS-CHD odds ratio, 1.02; 95% CI, 0.99-1.05). This contrasted with a strong association in CARDIoGRAMPlusC4D odds ratio 1.20; 95% CI, 1.18-1.22; P for interaction <0.001 compared with the GENIUS-CHD estimate. Similarly, no clear associations were identified for additional subsequent outcomes, including all-cause death, although we found a modest positive association between chromosome 9p21 and subsequent revascularization (odds ratio, 1.07; 95% CI, 1.04-1.09).

conclusionsIn contrast to studies comparing individuals with CHD to disease-free controls, we found no clear association between genetic variation at chromosome 9p21 and risk of subsequent acute CHD events when all individuals had CHD at baseline. However, the association with subsequent revascularization may support the postulated mechanism of chromosome 9p21 for promoting atheroma development.

Indexed as

Chromosomes, Human, Pair 9Case-Control StudiesCoronary Artery DiseaseFemaleGene FrequencyGenetic Predisposition to DiseaseHumansMaleMiddle AgedMyocardial InfarctionOdds RatioRisk Factorschromosomegeneticmyocardial infarctionrisk factorsecondary preventionvariation

Identifiers

PMID30897348
PMCPMC6625876

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