Evidence map›Paper›PMID 30899071›Full record

ArticleScientific reports2019

Transgenic substitution with Greater Amberjack Seriola dumerili fish insulin 2 in NOD mice reduces beta cell immunogenicity.

Kylie S Foo, Alicja A Skowronski, Danielle Baum, Rebuma Firdessa-Fite, Sebastian Thams, Linshan Shang, Rémi J Creusot, Charles A LeDuc, Dieter Egli, Rudolph L Leibel

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Kylie S FooDivision of Molecular Genetics, Department of Pediatrics and Naomi Berrie Diabetes Center, Columbia University, New York, NY, USA.
Alicja A SkowronskiDivision of Molecular Genetics, Department of Pediatrics and Naomi Berrie Diabetes Center, Columbia University, New York, NY, USA.
Danielle BaumDivision of Molecular Genetics, Department of Pediatrics and Naomi Berrie Diabetes Center, Columbia University, New York, NY, USA.
Rebuma Firdessa-FiteDepartment of Medicine, Columbia Center for Translational Immunology and Naomi Berrie Diabetes Center, Columbia University, New York, NY, USA.
Sebastian ThamsDepartments of Pathology and Cell Biology, Center for Motor Neuron Biology and Disease, Columbia University Medical Center, New York, NY, USA.
Linshan ShangDivision of Molecular Genetics, Department of Pediatrics and Naomi Berrie Diabetes Center, Columbia University, New York, NY, USA.
Rémi J CreusotDepartment of Medicine, Columbia Center for Translational Immunology and Naomi Berrie Diabetes Center, Columbia University, New York, NY, USA.
Charles A LeDucDivision of Molecular Genetics, Department of Pediatrics and Naomi Berrie Diabetes Center, Columbia University, New York, NY, USA.
Dieter EgliDivision of Molecular Genetics, Department of Pediatrics and Naomi Berrie Diabetes Center, Columbia University, New York, NY, USA. de2220@columbia.edu.
Rudolph L LeibelDivision of Molecular Genetics, Department of Pediatrics and Naomi Berrie Diabetes Center, Columbia University, New York, NY, USA. rl232@columbia.edu.
Columbia University · USIntegrated Cardio Metabolic Centre · SEKarolinska Institutet · SEUniversity of Minnesota · US

Funding

RESEARCH TRAININGP30DK026687 · NIDDK · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI Anthony W Ferrante, DYMPNA GALLAGHER · 1986 to 2026
$33.0M
POSTDOCTORAL TRAINING IN ARTERIOSCLEROSIS RESEARCHT32HL007343 · NHLBI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI HENRY N GINSBERG, Muredach P Reilly · 1985 to 2026
$12.7M
The molecular genetic analysis of human obesityR01DK052431 · NIDDK · ROCKEFELLER UNIVERSITY · PI CHUNG, WENDY K, LEIBEL, RUDOLPH L · 1996 to 2020
$11.6M
NUTRITIONT32DK007647 · NIDDK · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Anthony W Ferrante, Lori M Zeltser · 1990 to 2026
$7.4M
NHLBI NIH HHS T32 HL007343NIDDK NIH HHS P30 DK026687NIDDK NIH HHS R01 DK052431NIDDK NIH HHS T32 DK007647
6 · The paper itself

Abstract

Type I diabetes (T1D) is caused by immune-mediated destruction of pancreatic beta cells. This process is triggered, in part, by specific (aa 9-23) epitopes of the insulin Β chain. Previously, fish insulins were used clinically in patients allergic to bovine or porcine insulin. Fish and human insulin differ by two amino acids in the critical immunogenic region (aa 9-23) of the B chain. We hypothesized that β cells synthesizing fish insulin would be less immunogenic in a mouse model of T1D. Transgenic NOD mice in which Greater Amberjack fish (Seriola dumerili) insulin was substituted for the insulin 2 gene were generated (mouse Ins1

Indexed as

Amino Acid SequenceAnimalsCD4-Positive T-LymphocytesDiabetes Mellitus, ExperimentalEpitopesHumansInsulinInsulin-Secreting CellsIslets of Langerhans TransplantationKidneyLymphocyte ActivationMice, Inbred NODMice, TransgenicEpitopesInsulin

Identifiers

PMID30899071
PMCPMC6428854
OpenAlexW2924670220

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.