Evidence map›Paper›PMID 30899395›Full record

ArticleAmerican journal of translational research2019

Brain natriuretic peptide mitigates TIMP2 induction and reinstates extracellular matrix catabolic activity

Qiongqiong Guo, Junxia Wang, Yan Ge, Deepak K Malhotra, Lance D Dworkin, Pei Wang, Rujun Gong

Open access · greenAbstract read
In one paragraph

Article in American journal of translational research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Hormonal Regulation of Renal Fibrosis.Life (Basel, Switzerland) · 2022
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Qiongqiong GuoDepartment of Hemopurification Center, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology Luoyang, China.
Junxia WangDepartment of Hemopurification Center, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology Luoyang, China.
Yan GeInstitute of Nephrology, Blood Purification Center, The First Affiliated Hospital of Zhengzhou University Zhengzhou, China.
Deepak K MalhotraDivision of Nephrology, Department of Medicine, University of Toledo College of Medicine Toledo, Ohio, USA.
Lance D DworkinDivision of Nephrology, Department of Medicine, University of Toledo College of Medicine Toledo, Ohio, USA.
Pei WangInstitute of Nephrology, Blood Purification Center, The First Affiliated Hospital of Zhengzhou University Zhengzhou, China.
Rujun GongDivision of Nephrology, Department of Medicine, University of Toledo College of Medicine Toledo, Ohio, USA.
University of Toledo · USFirst Affiliated Hospital of Henan University of Science and Technology · CNFirst Affiliated Hospital of Zhengzhou University · CN

Funding

Therapeutic targeting of GSK3beta: A novel approach for podocyte protectionR01DK092485 · NIDDK · RHODE ISLAND HOSPITAL · PI GONG, RUJUN · 2011 to 2015
$1.8M
The Melanocortinergic pathway inglomerular diseaseR01DK114006 · NIDDK · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI GONG, RUJUN · 2017 to 2021
$1.8M
NIDDK NIH HHS R01 DK092485NIDDK NIH HHS R01 DK114006
6 · The paper itself

Abstract

Brain natriuretic peptide (BNP) has a demonstrable anti-fibrotic effect on diverse organ systems, including the kidney. To understand the molecular mechanism underlying this renoprotective effect, the efficacy of BNP was examined in an

Indexed as

Brain natriuretic peptidecell cultureextra cellular matrixfibrosisglomerular diseaseglycogen synthase kinase 3βpodocytestransforming growth factor β1

Identifiers

PMID30899395
PMCPMC6413260
OpenAlexW3022303483

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.