Evidence map›Paper›PMID 30907888›Full record

ArticleJournal of visualized experiments : JoVE2019

Ultrasound Imaging of the Thoracic and Abdominal Aorta in Mice to Determine Aneurysm Dimensions.

Hisashi Sawada, Jeff Z Chen, Bradley C Wright, Jessica J Moorleghen, Hong S Lu, Alan Daugherty

Abstract readVideo-Audio Media
In one paragraph

Article in Journal of visualized experiments : JoVE, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
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  18. Article
  19. Authentication of In Situ Measurements for Thoracic Aortic Aneurysms in Mice.Arteriosclerosis, thrombosis, and vascular biology · 2021
    Article
  20. Ultrasound Monitoring of Descending Aortic Aneurysms and Dissections in Mice.Arteriosclerosis, thrombosis, and vascular biology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hisashi SawadaSaha Cardiovascular Research Center, University of Kentucky.
Jeff Z ChenDepartment of Physiology, University of Kentucky.
Bradley C WrightSaha Cardiovascular Research Center, University of Kentucky.
Jessica J MoorleghenSaha Cardiovascular Research Center, University of Kentucky.
Hong S LuSaha Cardiovascular Research Center, University of Kentucky; Department of Physiology, University of Kentucky.
Alan DaughertySaha Cardiovascular Research Center, University of Kentucky; Department of Physiology, University of Kentucky; alan.daugherty@uky.edu.

Funding

Kentucky Center for Clinical and Translational ScienceUL1TR001998 · NCATS · UNIVERSITY OF KENTUCKY · PI HARTMANN, KATHERINE E, KERN, PHILIP A · 2016 to 2025
$34.2M
Adventitial-medial interactions in thoracic aortic diseasesR01HL133723 · NHLBI · UNIVERSITY OF KENTUCKY · PI DAUGHERTY, ALAN · 2016 to 2019
$2.9M
Atherosclerosis Mechanisms: Angiotensin II production and actionR01HL139748 · NHLBI · UNIVERSITY OF KENTUCKY · PI DAUGHERTY, ALAN, LU, HONG SHEN · 2018 to 2021
$2.0M
NCATS NIH HHS UL1 TR001998NHLBI NIH HHS R01 HL133723NHLBI NIH HHS R01 HL139748
6 · The paper itself

Abstract

Contemporary high-resolution ultrasound instruments have sufficient resolution to facilitate the measurement of mouse aortas. These instruments have been widely used to measure aortic dimensions in mouse models of aortic aneurysms. Aortic aneurysms are defined as permanent dilations of the aorta, which occur most frequently in the ascending and abdominal regions. Sequential measurements of aortic dimensions by ultrasound are the principal approach for assessing the development and progression of aortic aneurysms in vivo. Although many reported studies used ultrasound imaging to measure aortic diameters as a primary endpoint, there are confounding factors, such as probe position and cardiac cycle, that may impact the accuracy of data acquisition, analysis, and interpretation. The purpose of this protocol is to provide a practical guide on the use of ultrasound to measure the aortic diameter in a reliable and reproducible manner. This protocol introduces the preparation of mice and instruments, the acquisition of appropriate ultrasound images, and data analysis.

Indexed as

AnimalsAorta, AbdominalAorta, ThoracicAortic AneurysmDisease ProgressionHumansImage Processing, Computer-AssistedMaleMiceReproducibility of ResultsSoftwareUltrasonography

Identifiers

PMID30907888
PMCPMC6594159

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.