Evidence map›Paper›PMID 30913402›Full record

ArticleDevelopmental cell2019

Prometheus Unbound in Ya(p) Heart.

Jan W Buikema, Sean M Wu

Abstract readComment
PubMed Publisher
In one paragraph

Article in Developmental cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Jan W BuikemaDepartment of Cardiology, Utrecht Regenerative Medicine Center, University Utrecht, University Medical Center Utrecht, Utrecht University, 3508 GA Utrecht, the Netherlands; Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
Sean M WuCardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: smwu@stanford.edu.

Funding

Enabling Technologies for Human-Machine Hybrid TissuesDP1LM012179 · NLM · STANFORD UNIVERSITY · PI WU, SEAN M · 2014 to 2018
$3.8M
NLM NIH HHS DP1 LM012179
6 · The paper itself

Abstract

The adult mammalian heart, unlike in some amphibian and fish species, is generally considered a post-mitotic organ. In this issue of Developmental Cell, Monroe et al. (2019) show that the expression of constitutively active YAP induces a remarkable degree of proliferation in preexisting adult cardiomyocytes by globally altering chromatin accessibility.

Indexed as

ChromatinSignal TransductionAnimalsCell ProliferationMyocytes, CardiacChromatin

Identifiers

PMID30913402

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.