Evidence map›Paper›PMID 30919313›Full record

ReviewCurrent obesity reports2019

FSP27 and Links to Obesity and Diabetes Mellitus.

Shakun Karki

Abstract readReview
In one paragraph

Review in Current obesity reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Shakun KarkiEvans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, 88 East Newton St, Boston, MA, 02118, USA. shakunk@bu.edu.

Funding

FSP27 regulation of vascular function in human obesityK01DK114897 · NIDDK · BOSTON UNIVERSITY MEDICAL CAMPUS · PI KARKI, SHAKUN · 2018 to 2021
$608k
Foundation for the National Institutes of Health K01DK114897NIDDK NIH HHS K01 DK114897
6 · The paper itself

Abstract

purpose of reviewObesity is a pandemic, yet preventable healthcare problem. Insulin resistance, diabetes mellitus, dyslipidemia, and cardiovascular complications are core manifestation of obesity. While adipose tissue is a primary site of energy storage, it is also an endocrine organ, secreting a large number of adipokines and cytokines. Nonetheless in obesity, the secretion of cytokines and free fatty acids increases significantly and is associated with the degree of adiposity and insulin resistance. Fat-specific protein 27 (FSP27) has emerged as one of the major proteins that promote physiological storage of fat in adipose tissue. RECENT

findingsReview of number of recent findings suggests that FSP27 plays a crucial role in physiological storage of fat within the adipose tissue especially in humans. However, in disease conditions such as obesity, FSP27 may contribute to ectopic fat accumulation in non-adipose tissue. More studies are required to highlight the tissue-specific role of FSP27, especially in humans.

Indexed as

AdipokinesAdipose TissueAnimalsApoptosis Regulatory ProteinsDiabetes ComplicationsDiabetes MellitusHumansInsulin ResistanceLiverObesityAdipokinesApoptosis Regulatory ProteinsCIDEC protein, humanDiabetes mellitusFat-specific protein 27Insulin resistanceObesity

Identifiers

PMID30919313
PMCPMC6661191

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.