ReviewCirculation research2019
Neurovascular and Cognitive Dysfunction in Hypertension.
Review in Circulation research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 286 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
286 citing papers in PubMed, 6 syntheses or guidelines pooled it, 478 citations in OpenAlex.
- Impact of hypertension on brain function assessed by resting state functional MRI (rs-fMRI): a systematic review and meta-analysis.Brain imaging and behavior · 2026Pooled it
- Identification of cognitive impairment in patients with hypertension: a systematic review and critical appraisal of existing models.Frontiers in medicine · 2026Pooled it
- Arterial spin labeling MRI in assessing cerebral blood flow changes due to hypertension: a systematic review.Journal of hypertension · 2026Pooled it
- The role of the Mediterranean diet in reducing the risk of cognitive impairement, dementia, and Alzheimer's disease: a meta-analysis.GeroScience · 2025Pooled it
- Altered cerebral blood flow in older adults with Alzheimer's disease: a systematic review.Brain imaging and behavior · 2023Pooled it
- Knowledge gaps and future directions in cognitive functions in children and adolescents with primary arterial hypertension: A systematic review.Frontiers in cardiovascular medicine · 2022Pooled it
- Blood pressure parameters and cognitive decline and dementia after stroke or transient ischemic attack: results from the PROGRESS trial.American journal of hypertension · 2026Trial
- Effects of the herbal prescription Kami Guibi-tang on brain function in amnestic mild cognitive impairment: a task-based and resting-state fMRI study.Brain imaging and behavior · 2026Trial
- Sleep Quality, Metabolic Function, Physical Activity, and Neurocognition Among Individuals with Resistant Hypertension.Journal of Alzheimer's disease : JAD · 2023Trial
- The Effect of a Neuronal Nitric Oxide Synthase Inhibitor on Neurovascular Regulation in Humans.Circulation research · 2022Trial
- Examining the Associations between Post-Stroke Cognitive Function and Common Comorbid Conditions among Stroke Survivors.International journal of environmental research and public health · 2022Trial
- Effect of intensive blood pressure control on subtypes of mild cognitive impairment and risk of progression from SPRINT study.Journal of the American Geriatrics Society · 2022Trial
- Alzheimer's Disease in the Era of Geroscience: Mechanisms, Biomarkers, and Therapeutic Prospects.Cells · 2026Review
- Impaired Intracranial Compliance: A New Hypertension-Mediated Brain Organ Damage?High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2026Article
- Advances in Alzheimer's disease: mechanistic insights and therapeutic targets.Science China. Life sciences · 2026Review
- Caregiving for Older Adults with Hypertension: A Scoping Review.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2026Review
- Repeated ethanol exposure in female rats impairs cerebral endothelial function and increases cerebrovascular stiffness.European journal of pharmacology · 2026Article
- Cognitive Decline in Chronic Coronary Syndrome: Associations with Vascular, Cardiac, and Neuropsychological Parameters.Medicina (Kaunas, Lithuania) · 2026Observational
- Hydrogen sulfide mitigates spatial learning deficits in angiotensin II-Induced hypertension via inhibition of endothelial NOX2 and neuroinflammation.Translational psychiatry · 2026Article
- Cardiovascular risk and hippocampal-cognitive coupling in Alzheimer's disease.medRxiv : the preprint server for health sciences · 2026Article
226 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Hypertension has emerged as a leading cause of age-related cognitive impairment. Long known to be associated with dementia caused by vascular factors, hypertension has more recently been linked also to Alzheimer disease-the major cause of dementia in older people. Thus, although midlife hypertension is a risk factor for late-life dementia, hypertension may also promote the neurodegenerative pathology underlying Alzheimer disease. The mechanistic bases of these harmful effects remain to be established. Hypertension is well known to alter in the structure and function of cerebral blood vessels, but how these cerebrovascular effects lead to cognitive impairment and promote Alzheimer disease pathology is not well understood. Furthermore, critical questions also concern whether treatment of hypertension prevents cognitive impairment, the blood pressure threshold for treatment, and the antihypertensive agents to be used. Recent advances in neurovascular biology, epidemiology, brain imaging, and biomarker development have started to provide new insights into these critical issues. In this review, we will examine the progress made to date, and, after a critical evaluation of the evidence, we will highlight questions still outstanding and seek to provide a path forward for future studies.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.