Evidence map›Paper›PMID 30924548›Full record

ArticleJournal of the American Geriatrics Society2019

Quality of Life of Caregivers of Older Patients with Advanced Cancer.

Lee A Kehoe, Huiwen Xu, Paul Duberstein, Kah Poh Loh, Eva Culakova, Beverly Canin, Arti Hurria, William Dale, Megan Wells, Nikesha Gilmore and 10 more

Open access · greenAbstract readMulticenter Study
In one paragraph

Article in Journal of the American Geriatrics Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 4 pooled it
11.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 4 syntheses or guidelines pooled it, 91 citations in OpenAlex.

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  17. Longitudinal changes in physical and psychological outcomes in spousal vs. non-spousal caregivers for patients with end-stage liver disease.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors at 9 institutions in 1 country.

Lee A KehoeURCC NCORP Research Base, University of Rochester Medical Center, Rochester, New York.
Huiwen XuURCC NCORP Research Base, University of Rochester Medical Center, Rochester, New York.
Paul DubersteinRutgers School of Public Health, New Brunswick, New Jersey.
Kah Poh LohURCC NCORP Research Base, University of Rochester Medical Center, Rochester, New York.
Eva CulakovaURCC NCORP Research Base, University of Rochester Medical Center, Rochester, New York.
Beverly CaninSCOREboard Advisory Group, University of Rochester Medical Center, Rochester, New York.
Arti HurriaCity of Hope National Medical Center, Duarte, California.
William DaleUniversity of North Carolina, Chapel Hill, North Carolina.
Megan WellsURCC NCORP Research Base, University of Rochester Medical Center, Rochester, New York.
Nikesha GilmoreURCC NCORP Research Base, University of Rochester Medical Center, Rochester, New York.
Amber S KlecknerURCC NCORP Research Base, University of Rochester Medical Center, Rochester, New York.
Jennifer LundUniversity of North Carolina, Chapel Hill, North Carolina.
Charles KamenURCC NCORP Research Base, University of Rochester Medical Center, Rochester, New York.
Marie FlanneryURCC NCORP Research Base, University of Rochester Medical Center, Rochester, New York.
Mike HoergerTulane University, New Orleans, Louisiana.
Judith O HopkinsSoutheast Clinical Oncology Research (SCOR), Consortium NCI Community Oncology Research Program (NCORP), Winston Salem, North Carolina; Novant Health-GWSM.
Jane Jijun LiuHeartland NCORP, Decatur, Illinois.
Jodi GeerMetro-Minnesota NCORP, St. Louis Park, Minnesota.
Ron EpsteinURCC NCORP Research Base, University of Rochester Medical Center, Rochester, New York.
Supriya G MohileURCC NCORP Research Base, University of Rochester Medical Center, Rochester, New York.
University of Rochester Medical Center · USUniversity of North Carolina at Chapel Hill · USCity Of Hope National Medical Center · USHeartland Cancer Research · USMetro-Minnesota Community Oncology Research Consortium · USRutgers, The State University of New Jersey · USSoutheast Clinical Oncology Research Consortium · USTulane University · USUniversity of Rochester · US

Funding

URCC NCORP Research BaseUG1CA189961 · NCI · UNIVERSITY OF ROCHESTER · PI Michelle C Janelsins, KAREN M. MUSTIAN · 2014 to 2026
$67.7M
Geriatric Oncology Research Infrastructure to Improve Clinical CareR33AG059206 · NIA · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI WILLIAM DALE, Heidi Diana Klepin · 2020 to 2026
$5.1M
Reducing Chemotherapy Toxicity in Older AdultsR01CA177592 · NCI · UNIVERSITY OF ROCHESTER · PI MOHILE, SUPRIYA G. · 2013 to 2018
$3.0M
A Patient-Oriented Research Program in Geriatric OncologyK24AG056589 · NIA · UNIVERSITY OF ROCHESTER · PI Supriya G. Mohile · 2018 to 2026
$1.5M
Geriatric Oncology Research Infrastructure to Improve Clinical CareR21AG059206 · NIA · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI DALE, WILLIAM, MOHILE, SUPRIYA G. · 2018 to 2019
$478k
NCI NIH HHS R01 CA177592NCI NIH HHS UG1 CA189961NIA NIH HHS K24 AG056589NIA NIH HHS R21 AG059206NIA NIH HHS R33 AG059206Patient-Centered Outcomes Research Institute 4634
6 · The paper itself

Abstract

objectivesTo evaluate the relationships between aging-related domains captured by geriatric assessment (GA) for older patients with advanced cancer and caregivers' emotional health and quality of life (QOL).

designIn this cross sectional study of baseline data from a nationwide investigation of older patients and their caregivers, patients completed a GA that included validated tests to evaluate eight domains of health (eg, function, cognition).

settingThirty-one community oncology practices throughout the United States.

participantsEnrolled patients were aged 70 and older, had one or more GA domain impaired, and had an incurable solid tumor malignancy or lymphoma. Each could choose one caregiver to enroll. MEASUREMENTS: Caregivers completed the Generalized Anxiety Disorder-7, Distress Thermometer, Patient Health Questionnaire-2 (depression), and Short Form Health Survey-12 (SF-12 for QOL). Separate multivariate linear or logistic regression models were used to examine the association of the number and type of patient GA impairments with caregiver outcomes, controlling for patient and caregiver covariates.

resultsA total of 541 patients were enrolled, 414 with a caregiver. Almost half (43.5%) of the caregivers screened positive for distress, 24.4% for anxiety, and 18.9% for depression. Higher numbers of patient GA domain impairments were associated with caregiver depression (adjusted odds ratio [aOR] = 1.29; P < .001], caregiver physical health on SF-12 (regression coefficient [β] = -1.24; P < .001), and overall caregiver QOL (β = -1.14; P < .01). Impaired patient function was associated with lower caregiver QOL (β = -4.11; P < .001). Impaired patient nutrition was associated with caregiver depression (aOR = 2.08; P < .01). Lower caregiver age, caregiver comorbidity, and patient distress were also associated with worse caregiver outcomes.

conclusionPatient GA impairments were associated with poorer emotional health and lower QOL of caregivers. J Am Geriatr Soc 67:969-977, 2019.

Indexed as

Mental HealthAdultAgedAged, 80 and overAnxietyCaregiversCognitionCross-Sectional StudiesDepressionEmotionsFemaleGeriatric AssessmentHumansIncidenceMaleMiddle Agedcaregiversemotional healthgeriatric assessmentquality of life

Identifiers

PMID30924548
PMCPMC7818364
OpenAlexW2928441960

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.