Evidence map›Paper›PMID 30925290›Full record

ArticleCell calcium2019

MiR-204 regulates type 1 IP

Mohanad Gabani, Jing Liu, Karima Ait-Aissa, Olha Koval, Young-Rae Kim, Diana Castañeda, Ajit Vikram, Julia S Jacobs, Isabella Grumbach, Mohamed Trebak and 2 more

Abstract read
In one paragraph

Article in Cell calcium, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Article
  3. The role of IPPflugers Archiv : European journal of physiology · 2026
    Review
  4. Article
  5. Review
  6. Article
  7. Neuronal microRNAs safeguard ER CaCellular and molecular life sciences : CMLS · 2022
    Article
  8. Review
  9. MicroRNAs in cardiovascular diseases.Medical review (2021) · 2022
    Review
  10. Article
  11. Article
  12. Article
  13. IP3R Channels in Male Reproduction.International journal of molecular sciences · 2020
    Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mohanad GabaniCardiovascular Division, Department of Medicine, Abboud Cardiovascular Research Center, University of Iowa, Carver College of Medicine, Iowa City, IA, USA.
Jing LiuCardiovascular Division, Department of Medicine, Abboud Cardiovascular Research Center, University of Iowa, Carver College of Medicine, Iowa City, IA, USA.
Karima Ait-AissaCardiovascular Division, Department of Medicine, Abboud Cardiovascular Research Center, University of Iowa, Carver College of Medicine, Iowa City, IA, USA.
Olha KovalCardiovascular Division, Department of Medicine, Abboud Cardiovascular Research Center, University of Iowa, Carver College of Medicine, Iowa City, IA, USA.
Young-Rae KimCardiovascular Division, Department of Medicine, Abboud Cardiovascular Research Center, University of Iowa, Carver College of Medicine, Iowa City, IA, USA.
Diana CastañedaCalifornia State University, Los Angeles, CA, USA.
Ajit VikramCardiovascular Division, Department of Medicine, Abboud Cardiovascular Research Center, University of Iowa, Carver College of Medicine, Iowa City, IA, USA.
Julia S JacobsCardiovascular Division, Department of Medicine, Abboud Cardiovascular Research Center, University of Iowa, Carver College of Medicine, Iowa City, IA, USA.
Isabella GrumbachCardiovascular Division, Department of Medicine, Abboud Cardiovascular Research Center, University of Iowa, Carver College of Medicine, Iowa City, IA, USA.
Mohamed TrebakDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA.
Kaikobad IraniCardiovascular Division, Department of Medicine, Abboud Cardiovascular Research Center, University of Iowa, Carver College of Medicine, Iowa City, IA, USA. Electronic address: Kaikobad-Irani@uiowa.edu.
Modar KassanCardiovascular Division, Department of Medicine, Abboud Cardiovascular Research Center, University of Iowa, Carver College of Medicine, Iowa City, IA, USA. Electronic address: modar-kassan@uiowa.edu.

Funding

INTERDISCIPLINARY CARDIOVASCULAR RESEARCH FELLOWSHIPT32HL007121 · NHLBI · UNIVERSITY OF IOWA · PI LONDON, BARRY · 1985 to 2020
$15.1M
Receptor-regulated Ca2+ Entry Pathways in Smooth MuscleR01HL097111 · NHLBI · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI TREBAK, MOHAMED · 2010 to 2019
$3.7M
Mitochondrial CaMKII drives smooth muscle migration and neointimal hyperplasiaR01HL108932 · NHLBI · UNIVERSITY OF IOWA · PI GRUMBACH, ISABELLA MARIA · 2012 to 2021
$3.6M
Leukotriene C4 and STIM/Orai channels in airway smooth muscle remodelingR01HL123364 · NHLBI · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI TREBAK, MOHAMED · 2014 to 2017
$1.5M
Mitochondrial CAMKII in smooth muscle as key regulator of hypertension and vascular remodelingI01BX000163 · VA · OKLAHOMA CITY VA MEDICAL CENTER · PI Isabella Maria Grumbach · 2011 to 2026
–
SIRTUIN1-mediated inhibition of p66shc lysine acetylation as a novel treatment for diabetic vasculopathyI01BX002940 · VA · PROVIDENCE VA MEDICAL CENTER · PI IRANI, KAIKOBAD J. · 2016 to 2024
–
BLRD VA I01 BX000163BLRD VA I01 BX002940NHLBI NIH HHS R01 HL097111NHLBI NIH HHS R01 HL108932NHLBI NIH HHS R01 HL123364NHLBI NIH HHS T32 HL007121
6 · The paper itself

Abstract

MiR-204 is expressed in vascular smooth muscle cells (VSMC). However, its role in VSMC contraction is not known. We determined if miR-204 controls VSMC contractility and blood pressure through regulation of sarcoplasmic reticulum (SR) calcium (Ca

Indexed as

Angiotensin IIAnimalsAortaBlood PressureCalcium SignalingCells, CulturedDisease Models, AnimalHumansHypertensionInositol 1,4,5-Trisphosphate ReceptorsMesenteric ArteriesMiceMice, Inbred C57BLMice, KnockoutMicroRNAsMuscle ContractionAngiotensin IIInositol 1,4,5-Trisphosphate ReceptorsItpr1 protein, mouseMicroRNAsMIRN204 microRNA, mouseCalciumHypertensionIP3R1MiR-204Vascular smooth mucsle cells contractility

Identifiers

PMID30925290
PMCPMC6767906

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.