Evidence map›Paper›PMID 30925657›Full record

ArticleMolecules (Basel, Switzerland)2019

Activity of Estafietin and Analogues on

Valeria P Sülsen, Emilio F Lizarraga, Orlando G Elso, Natacha Cerny, Andrés Sanchez Alberti, Augusto E Bivona, Emilio L Malchiodi, Silvia I Cazorla, César A N Catalán

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Review
  3. Extracts and Terpenoids fromMolecules (Basel, Switzerland) · 2024
    Article
  4. Review
  5. Anti-Pharmaceutics · 2023
    Article
  6. Anthelmintic activity ofParasitology · 2022
    Article
  7. Article
  8. Antiparasitic Effects of Asteraceae Species Extracts onEvidence-based complementary and alternative medicine : eCAM · 2022
    Article
  9. Molecules (Basel, Switzerland) · 2021
    Review
  10. Article
  11. Current trends in the pharmacological management of Chagas disease.International journal for parasitology. Drugs and drug resistance · 2020
    Review
  12. Lychnopholide in Poly(d,l-Lactide)-Antimicrobial agents and chemotherapy · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Valeria P SülsenCONICET-Universidad de Buenos Aires, Instituto de Química y Metabolismo del Fármaco (IQUIMEFA), Junín 956 2° floor, Buenos Aires 1113, Argentina. vsulsen@ffyb.uba.ar.
Emilio F LizarragaInstituto de Fisiología Animal, Fundación Miguel Lillo and Facultad de Ciencias Naturales e Instituto Miguel Lillo, Universidad Nacional de Tucumán, Tucumán T4000INI, Argentina. eflizarraga@lillo.org.ar.ORCID 0000-0001-7122-9329
Orlando G ElsoCONICET-Universidad de Buenos Aires, Instituto de Química y Metabolismo del Fármaco (IQUIMEFA), Junín 956 2° floor, Buenos Aires 1113, Argentina. orlandoelso@hotmail.com.
Natacha CernyCONICET-Universidad Nacional de Luján, Instituto de Ecología y Desarrollo Sustentable (INEDES), Ruta 5 y Avenida Constitución, Luján 6700, Argentina. natachacerny@gmail.com.ORCID 0000-0002-8217-3903
Andrés Sanchez AlbertiCátedra de Inmunología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956 4° floor, Buenos Aires 1113, Argentina. andres.sanchez.alberti@gmail.com.ORCID 0000-0001-5369-2889
Augusto E BivonaCátedra de Inmunología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956 4° floor, Buenos Aires 1113, Argentina. augustobivona@gmail.com.
Emilio L MalchiodiCátedra de Inmunología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956 4° floor, Buenos Aires 1113, Argentina. emalchio@ffyb.uba.ar.
Silvia I CazorlaCONICET-Universidad de Buenos Aires, Instituto de Microbiología y Parasitología Médica-CONICET (IMPaM), Facultad de Medicina, Paraguay 2155. 13° floor, Buenos Aires C1121ABG, Argentina. silcazorla@yahoo.es.
César A N CatalánCONICET-Universidad Nacional de Tucumán, Instituto de Química del Noroeste-CONICET (INQUINOA), Ayacucho 471, San Miguel de Tucumán T4000INI, Argentina. ccatalan@fbqf.unt.edu.ar.
Consejo Nacional de Investigaciones Científicas y Técnicas · ARNational University of Tucumán · AR

Funding

Agencia Nacional de Promoción Científica y Tecnológica PICT 2015-3531Consejo Nacional de Investigaciones Científicas y Técnicas PIP11220150100158COUniversidad de Buenos Aires UBACYT 20020170100316BA
6 · The paper itself

Abstract

Sesquiterpene lactones are naturally occurring compounds mainly found in the Asteraceae family. These types of plant metabolites display a wide range of biological activities, including antiprotozoal activity and are considered interesting structures for drug discovery. Four derivatives were synthesized from estafietin (

Indexed as

AnimalsAntiparasitic AgentsAntiprotozoal AgentsCarbon-13 Magnetic Resonance SpectroscopyCell DeathChlorocebus aethiopsLeishmania braziliensisProton Magnetic Resonance SpectroscopySesquiterpenes, GuaianeTrypanosoma cruziVero CellsAntiparasitic AgentsAntiprotozoal AgentsestafietinSesquiterpenes, GuaianeLeishmania braziliensissesquiterpene lactonesStevia alpinaTrypanosoma cruzi

Identifiers

PMID30925657
PMCPMC6479983
OpenAlexW2924347252

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.