Evidence map›Paper›PMID 30925934›Full record

ArticleClinical epigenetics2019

Prenatal maternal antidepressants, anxiety, and depression and offspring DNA methylation: epigenome-wide associations at birth and persistence into early childhood.

Andres Cardenas, Sabrina Faleschini, Andrea Cortes Hidalgo, Sheryl L Rifas-Shiman, Andrea A Baccarelli, Dawn L DeMeo, Augusto A Litonjua, Alexander Neumann, Janine F Felix, Vincent W V Jaddoe and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical epigenetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 6 pooled it
8.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 6 syntheses or guidelines pooled it, 72 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 9 institutions in 3 countries.

Andres CardenasDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, Berkeley, CA, USA. andres.cardenas@berkeley.edu.ORCID 0000-0003-2284-3298
Sabrina FaleschiniSchool of Psychology, Laval University, Quebec, QC, Canada.
Andrea Cortes HidalgoDepartment of Child and Adolescent Psychiatry and Psychology, Erasmus MC - Sophia Children's Hospital, Rotterdam, the Netherlands.
Sheryl L Rifas-ShimanDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Andrea A BaccarelliDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA.
Dawn L DeMeoChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Augusto A LitonjuaDivision of Pediatric Pulmonary Medicine, University of Rochester Medical Center, Rochester, NY, USA.
Alexander NeumannDepartment of Child and Adolescent Psychiatry and Psychology, Erasmus MC - Sophia Children's Hospital, Rotterdam, the Netherlands.
Janine F FelixGeneration R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Vincent W V JaddoeGeneration R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Hanan El MarrounDepartment of Child and Adolescent Psychiatry and Psychology, Erasmus MC - Sophia Children's Hospital, Rotterdam, the Netherlands.
Henning TiemeierDepartment of Child and Adolescent Psychiatry and Psychology, Erasmus MC - Sophia Children's Hospital, Rotterdam, the Netherlands.
Emily OkenDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, Berkeley, CA, USA.
Marie-France HivertDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Heather H BurrisDivision of Neonatology, Department of Pediatrics, Children's Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Erasmus MC · NLBerkeley Public Health Division · USErasmus MC - Sophia Children’s Hospital · NLHarvard University · USBrigham and Women's Hospital · USChildren's Hospital of Philadelphia · USColumbia University · USUniversité Laval · CAUniversity of Rochester Medical Center · US

Funding

VISUAL INDICES OF NEUROTOXICITYP30ES001247 · NIEHS · UNIVERSITY OF ROCHESTER · PI Martha Susiarjo · 1985 to 2026
$42.8M
Prenatal environmental determinants of health in young adulthood: a lifecourse approachR01HD034568 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI Marie-France Hivert, Emily Oken · 1998 to 2026
$20.6M
Common and distinct early environmental influences on cardiometabolic and respiratory health: Mechanisms and methodsUH3OD023286 · OD · HARVARD PILGRIM HEALTH CARE, INC. · PI OKEN, EMILY · 2018 to 2022
$11.7M
Common and distinct early environmental influences on cardiometabolic and respiratory health: Mechanisms and methodsUG3OD023286 · OD · HARVARD PILGRIM HEALTH CARE, INC. · PI KLEINMAN, KENNETH P., OKEN, EMILY · 2016 to 2017
$4.1M
Early Life DNA Methylation and Childhood Allergic DiseaseR01HL111108 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI DEMEO, DAWN L · 2013 to 2016
$3.0M
Novel Epigenomic Biomarkers of Prenatal Risk Factors, and Childhood ObesityR01NR013945 · NINR · HARVARD SCHOOL OF PUBLIC HEALTH · PI BACCARELLI, ANDREA · 2013 to 2015
$1.6M
Epigenetic Pathways to Conduct Problem Trajectories: Early Environmental RisksR01HD068437 · NICHD · KING'S COLLEGE LONDON · PI BARKER, EDWARD D., MILL, JONATHAN · 2012 to 2014
$1.1M
The Toxic Environment and the Epigenetics of Fetal GrowthK23ES022242 · NIEHS · CHILDREN'S HOSP OF PHILADELPHIA · PI BURRIS, HEATHER HERSON · 2013 to 2017
$790k
NHLBI NIH HHS R01 HL111108NICHD NIH HHS R01 HD034568NICHD NIH HHS R01 HD068437NIEHS NIH HHS K23 ES022242NIEHS NIH HHS P30 ES001247NIH HHS UG3 OD023286NIH HHS UH3 OD023286NINR NIH HHS R01 NR013945
6 · The paper itself

Abstract

backgroundMaternal mood disorders and their treatment during pregnancy may have effects on the offspring epigenome. We aim to evaluate associations of maternal prenatal antidepressant use, anxiety, and depression with cord blood DNA methylation across the genome at birth and test for persistence of associations in early and mid-childhood blood DNA.

methodsA discovery phase was conducted in Project Viva, a prospective pre-birth cohort study with external replication in an independent cohort, the Generation R Study. In Project Viva, pregnant women were recruited between 1999 and 2002 in Eastern Massachusetts, USA. In the Generation R Study, pregnant women were recruited between 2002 and 2006 in Rotterdam, the Netherlands. In Project Viva, 479 infants had data on maternal antidepressant use, anxiety, depression, and cord blood DNA methylation, 120 children had DNA methylation measured in early childhood (~ 3 years), and 460 in mid-childhood (~ 7 years). In the Generation R Study, 999 infants had data on maternal antidepressants and cord blood DNA methylation. The prenatal antidepressant prescription was obtained from medical records. At-mid pregnancy, symptoms of anxiety and depression were assessed with the Pregnancy-Related Anxiety Scale and the Edinburgh Postnatal Depression Scale in Project Viva and with the Brief Symptom Inventory in the Generation R Study. Genome-wide DNA methylation was measured using the Infinium HumanMethylation450 BeadChip in both cohorts.

resultsIn Project Viva, 2.9% (14/479) pregnant women were prescribed antidepressants, 9.0% (40/445) experienced high pregnancy-related anxiety, and 8.2% (33/402) reported symptoms consistent with depression. Newborns exposed to antidepressants in pregnancy had 7.2% lower DNA methylation (95% CI, - 10.4, - 4.1; P = 1.03 × 10

conclusionsThe ZNF575 gene is involved in transcriptional regulation but specific functions are largely unknown. Given the widespread use of antidepressants in pregnancy, as well as the effects of exposure to anxiety and depression, implications of potential fetal epigenetic programming by these risk factors and their impacts on development merit further investigation.

Indexed as

AdultAntidepressive AgentsAnxietyChild, PreschoolDepressionDNA-Binding ProteinsDNA MethylationEpigenesis, GeneticFemaleFetal BloodHumansInfantInfant, NewbornMaleMaternal AgeMaternal ExposureAntidepressive AgentsDNA-Binding ProteinsTranscription FactorsZNF575 protein, humanAntidepressantsDNA methylationFetal programmingMaternal anxietyMaternal depression

Identifiers

PMID30925934
PMCPMC6441191
OpenAlexW2943557932

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.