Evidence map›Paper›PMID 30926644›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2019

Epitope Selection for HLA-DQ2 Presentation: Implications for Celiac Disease and Viral Defense.

Shu-Chen Hung, Tieying Hou, Wei Jiang, Nan Wang, Shuo-Wang Qiao, I-Ting Chow, Xiaodan Liu, Sjoerd H van der Burg, David M Koelle, William W Kwok and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Tuning DO:DM Ratios Modulates MHC Class II Immunopeptidomes.Molecular & cellular proteomics : MCP · 2022
    Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

Shu-Chen HungDivision of Human Gene Therapy, Department of Pediatrics, Stanford University, Stanford, CA 94305.
Tieying HouDivision of Human Gene Therapy, Department of Pediatrics, Stanford University, Stanford, CA 94305.
Wei JiangDivision of Human Gene Therapy, Department of Pediatrics, Stanford University, Stanford, CA 94305.
Nan WangDivision of Human Gene Therapy, Department of Pediatrics, Stanford University, Stanford, CA 94305.
Shuo-Wang QiaoCentre for Immune Regulation, Department of Immunology, University of Oslo and Oslo University Hospital, Rikshospitalet, 0372 Oslo, Norway.ORCID 0000-0002-0935-8397
I-Ting ChowBenaroya Research Institute at Virginia Mason, Seattle, WA 98101.ORCID 0000-0001-7278-8157
Xiaodan LiuDivision of Human Gene Therapy, Department of Pediatrics, Stanford University, Stanford, CA 94305.
Sjoerd H van der BurgDepartment of Medical Oncology, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands.ORCID 0000-0002-6556-0354
David M KoelleDepartment of Medicine, University of Washington, Seattle, WA 98195.ORCID 0000-0003-1255-9023
William W KwokBenaroya Research Institute at Virginia Mason, Seattle, WA 98101.ORCID 0000-0003-4843-4599
Ludvig M SollidCentre for Immune Regulation, Department of Immunology, University of Oslo and Oslo University Hospital, Rikshospitalet, 0372 Oslo, Norway.ORCID 0000-0001-8860-704X
Elizabeth D MellinsDivision of Human Gene Therapy, Department of Pediatrics, Stanford University, Stanford, CA 94305; mellins@stanford.edu.ORCID 0000-0003-2577-139X
Stanford University · USOslo University Hospital · NOVirginia Mason Medical Center · USLeiden University Medical Center · NLUniversity of Washington · US

Funding

MOLECULAR &CELLULAR IMMUNOBIOLOGYT32AI007290 · NIAID · STANFORD UNIVERSITY · PI Sean Curtis Bendall, Olivia M Martinez · 1985 to 2026
$27.0M
Genomic systems approach to measure HSV-1-specific T-cell dominance in humansR01AI094019 · NIAID · UNIVERSITY OF WASHINGTON · PI KOELLE, DAVID M · 2012 to 2016
$1.9M
MHC association in autoimmune arthritisR21AI075253 · NIAID · STANFORD UNIVERSITY · PI MELLINS, ELIZABETH D · 2008 to 2010
$486k
Immunoglobulin as a novel ligand for HLA-DMR21AI095813 · NIAID · STANFORD UNIVERSITY · PI MELLINS, ELIZABETH D · 2011 to 2012
$435k
Mechanism of MHC Association with Type 1 DiabetesR21DK079163 · NIDDK · STANFORD UNIVERSITY · PI MELLINS, ELIZABETH D · 2008 to 2009
$435k
NIAID NIH HHS R01 AI094019NIAID NIH HHS R21 AI075253NIAID NIH HHS R21 AI095813NIAID NIH HHS T32 AI007290NIDDK NIH HHS R21 DK079163
6 · The paper itself

Abstract

We have reported that the major histocompatibility molecule HLA-DQ2 (DQA1*05:01/DQB1*02:01) (DQ2) is relatively resistant to HLA-DM (DM), a peptide exchange catalyst for MHC class II. In this study, we analyzed the role of DQ2/DM interaction in the generation of DQ2-restricted gliadin epitopes, relevant to celiac disease, or DQ2-restricted viral epitopes, relevant to host defense. We used paired human APC, differing in DM expression (DM

Indexed as

Antigen PresentationAntigen-Presenting CellsCD4-Positive T-LymphocytesCeliac DiseaseCell LineEpitopes, T-LymphocyteGliadinHLA-DQ AntigensHumansViral ProteinsVirus DiseasesEpitopes, T-LymphocyteGliadinHLA-DQ2 antigenHLA-DQ AntigensViral Proteins

Identifiers

PMID30926644
PMCPMC6494460
OpenAlexW2928214347

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.